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Chemical can reproduce complications for some patients
Date:4/30/2009

BETHESDA, Md. (May 1, 2009) − Medical science took a giant leap forward with the development of techniques that, at least temporarily, perform the function of vital organs. These processes, including the use of the heart-lung machine and renal dialysis, require the blood to be circulated through tubing outside the body and are hence known as extracorporeal circulation (EC) and have provided critical life support for millions of patients. Yet EC is not without its own risks. Among them are unique morbidities such as depressed cardiac output, abnormal heart rhythm, and swelling of the major organs. Studies have been conducted for decades to determine how these effects can be reduced and eliminated. In a new study conducted by a Johns Hopkins team, the researchers examined whether a solvent used in the production of intravenous (IV) bags and EC circuits could play a role. Their results indicate that 1) the solvent cyclohexanone (CHX) can leach into IV and EC fluids, and 2) CHX administered in controlled doses in an animal model replicates the cardiovascular and lung morbidities that are seen in patients during and after EC treatment. The study sheds new light on the potential causes of EC-related disorders.

The study was conducted by Caitlin S. Thompson-Torgerson and Lakshmi Santhanam, Department of Biomedical Engineering; Hunter C. Champion, Department of Medicine (Division of Cardiology); Z. Leah Harris, Department of Anesthesiology and Critical Care Medicine; and Artin A. Shoukas, Departments of Biomedical Engineering, Anesthesiology and Critical Care Medicine, and Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD. The study, entitled Cyclohexanone Contamination From Extracorporeal Circuits Impairs Cardiovascular Function, is published in the online edition of the American Journal of PhysiologyHeart and Circulatory Physiology.

The Study

Cyclohexanone (CHX) is an organic solvent widely used i
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Contact: Donna Krupa
DKrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

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