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ChemBridge Research Laboratories, Inc. (CRL) has Established an Industry Record and Benchmark in Hit-to-Lead Libraries Turn-around Time
Date:8/7/2008

SAN DIEGO, Aug. 7 /PRNewswire/ -- ChemBridge Research Laboratories, Inc. (CRL) announced today that it has established an industry record in turn-around time for hit-to-lead follow-up libraries. Such ultra-fast hit-to-lead libraries are now produced in CRL's San Diego facilities in a matter of three to six days which enables critical acceleration of our clients' medicinal chemistry projects and sets a new industry benchmark. This state-of-the-art high-throughput chemistry technology was developed at CRL over the last seven years and refined in collaborations with Pfizer, Merck, AstraZeneca and others.

CRL's ultra-fast library production process is optimized at every step and includes: on-the-fly building block validation and protocol adjustment; one to three parallel synthesis steps across a very broad reaction range; high-throughput HPLC purification and LC/MS analysis; data processing; and robotic reformatting to ready-to-be-shipped custom plates/vials. The expertise, problem solving ability, and versatility of synthetic skills of CRL's chemists (the majority of whom are PhD's) also allow for rapid development of new parallel synthetic protocols and multi-step synthesis of intermediates and templates on-the-fly for the most challenging research-intensive hit-to-lead libraries.

"We are very pleased that our CRL chemists have been able to achieve speed and efficiency in hit-to-lead library production which even a year ago was not considered possible," said Eugene Vaisberg, Chairman and CEO of ChemBridge Corporation and CRL. "Their ability to produce and deliver high quality hit-to-lead libraries in less than a week continues the ChemBridge tradition of setting a gold standard in discovery chemistry outsourcing. It also offers a substantial competitive advantage for our clients allowing their precious medicinal chemistry resources to focus on their core expertise and to improve their hit-to-drug candidate success rate and timelines. This is of fo
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SOURCE ChemBridge Research Laboratories, Inc.
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