Navigation Links
Chaperone enzyme provides new target for cancer treatments
Date:1/18/2011

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases.

The enzyme, known as Rad18, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair. When Pol eta is not present, alternative error-prone polymerases take its place a process that leads to DNA mutations often found in cancer cells.

In one known example, faulty DNA repair due to Pol eta- deficiency is responsible for the genetic disease xeroderma pigmentosum-variant, which makes patients extremely susceptible to skin cancers caused by exposure to sunlight. However, scientists did not know how the cells selected the correct DNA Polymerase for error-free repair of each type of DNA damage.

"We found that the mechanism that promotes the 'chaperone' enzyme to recruit Pol eta to sites of DNA damage is managed by another signaling protein termed 'Cdc7' which we know is essential to normal regulation of the cellular lifecycle," said lead author Cyrus Vaziri, PhD, who is an associate professor of pathology and laboratory medicine and member of UNC Lineberger Comprehensive Cancer Center. Thus cells employ Cdc7 to ensure accurate DNA repair during the stage of their lifecycle that is most vulnerable to cancer-causing mutations.

The study was published in November in the Journal of Cell Biology.

According to Vaziri, the dual role that Cdc7 plays in the cell lifecycle and DNA repair offers a promising target for potential cancer therapies.

"We know that cancer cells have high levels of Cdc7 activity and can evade some DNA-damaging therapies such as cis-Platinum through Rad18 and Pol eta activity. We may be able to target this pathway in platinum-resistant tumors to preve
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists find donut-shaped structure of enzyme involved in energy metabolism
2. New Osteoarthritis Research Grant Program Initiated by AOSSM and Genzyme Biosurgery
3. California Day Spa - Osmosis Celebrates 25th Anniversary With Over 200,000 Cedar Enzyme Baths Given
4. Watch Your Cholesterol, Your Blood Pressure ... and This Enzyme?
5. New technique permits development of enzyme tool kit
6. New evidence that smokeless tobacco damages DNA and key enzymes
7. Researchers identify key enzyme in melanoma cell development
8. Researchers identify key enzyme in DNA repair pathway
9. Diabetes gene linked to degeneration of enzyme involved in Alzheimers disease onset and progression
10. Intestinal enzyme helps maintain population of beneficial bacteria
11. New 3-D model of RNA core domain of enzyme telomerase may offer clues to cancer, aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014 Fatigue, lack of ... increasing number of accidents in the workplace, according ... The articles highlight safety issues that contribute to ... accidents occur on the job annually, according to ... to explore "preventable workplace accidents." , Safety Issue: ...
(Date:7/10/2014)... 10, 2014 Ticketability.com has a wide array ... Paul McCartney tickets for San Diego are being added to ... since 1976, and the newly added September 28 show is ... Click Here to view the selection of discounted ... Park will become available to the general public on July ...
(Date:7/10/2014)... Colorado (PRWEB) July 10, 2014 ... will gather in Copenhagen this July 13-17 to ... bringing the world closer to breakthroughs in dementia ... the world’s largest conference of its kind. , ... AAIC serves as a catalyst for generating new ...
(Date:7/10/2014)... July 10, 2014 One week ahead ... Worker Safety announced today it will extend compensation benefits ... months’ wages for workers displaced as a result of ... Alliance inspections have resulted in the closure of five ... five cases, raising immediate safety concerns. In May, the ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Register to ... DataSite recently streamed the live webinar ‘Capitalizing on the ... from a group of several M&A experts in the ... the broader energy transaction marketplace. These experts shared their ... the deal market in this sector has been revitalized. ...
Breaking Medicine News(10 mins):Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 3Health News:Paul McCartney Tickets for San Diego: Ticketability.com Announces Discounted Tickets for McCartney’s Tour Stop at Petco Park on September 28 2Health News:Alliance for Bangladesh Worker Safety to Double Compensation for Displaced Factory Workers; Members Vote to Extend Wage Benefits from Two to up to Four Months 2Health News:Register to Download Merrill DataSite's Report: Capitalizing on the Shifting Sands of the Energy Market 2
... Fourth Quarter ... -- Revises 2008 EPS Guidance Primarily to Reflect the Sale of Medical ... Imaging, -- Reaffirms Expected Non-GAAP EPS CAGR ... Through 2010, Subject to Certain Assumptions, -- Completes Sale of Medical Imaging Business, Reports ...
... The Procter &,Gamble Company (NYSE: PG ) announced ... the quarter. Sales were up behind strong volume growth,from ... in developing regions. Organic volume increased six percent and,organic ... earnings per,share increased 17 percent to $0.98 per share, ...
... can qualify for up to $100,000 in bonuses, ... nation,s largest effort to reward physicians for,delivery of high ... to providing health care by launching the BTE Medical ... have,adopted really good systems and processes of care, and ...
... ... in Canada ... 31 ATS Medical, Inc.,(Nasdaq: ATSI ), manufacturer and marketer of state-of-the-art ... and clarification from the US Food and Drug,Administration (FDA) regarding its PMA approval ...
... Easter Seals, with funding from the,Ludy Family Foundation ... program to help returning veterans with Traumatic Brain ... an in-home,computer-based cognitive training program -- and by ... Seals services and supports., Signature Wound, Significant ...
... MINNEAPOLIS, Jan. 31 A new survey ... of Minnesotans support the,statewide smoke-free law, with 44 ... of strong support among all leading,demographics, including geography, ... survey was conducted by Minneapolis research,firm Decision Resources, ...
Cached Medicine News:Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 2Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 3Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 4Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 5Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 6Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 7Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 8Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 9Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 10Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 11Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 12Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 13Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 14Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 15Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 16Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 17Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 18Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 19Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 20Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 21Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 22Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 23Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 24Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 25Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 26Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 27Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 28Health News:Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007 29Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 2Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 3Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 4Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 5Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 6Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 7Health News:P&G Reports $0.98 EPS, Up 17%, on 9% Sales Growth; Announces Plan to Create Stand-Alone Coffee Company 8
(Date:7/10/2014)... NEWPORT NEWS, Virginia , 11. ... führender Hersteller von Kameras für die ... Brust (MBI/BSGI), hat heute die CE-Zulassung ... Mit dem CE-Zeichen kann Dilon das ... seinen Vertriebsbereich auf den Großteil der ...
(Date:7/10/2014)... 2014  The U.S. Department of Health and Human ... Hospitals (UH) Case Medical Center Seidman Cancer Center totaling ... at improving care for patients with complex cancer. ... test a unique model developed at UH to enhance ... comorbidities, or demonstrated need for high health care utilization.  ...
(Date:7/10/2014)... July 10, 2014  Breg, Inc., a premier ... launched the FreeRunner™ knee brace with new innovations ... patella mal-tracking return to active lifestyles.  FreeRunner,s patent-pending ... braces, providing support when patients need it most, ... don,t. Patellofemoral issues are the most ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2
... Mo., Feb. 14, 2011 K-V Pharmaceutical Company (NYSE: ... into a definitive agreement with a group of institutional ... from a private placement of 9,950,000 shares of its ... Company will use $20 million of the proceeds from ...
... commonly prescribed osteoporosis drug is associated with a slightly ... osteonecrosis of the jaw; nonetheless the risk remains extremely ... Journal of Dental Research, the official journal of ... the findings are provocative, study authors say they should ...
Cached Medicine Technology:K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 2K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 3K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 4K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 5K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 6K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 7K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 8K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 9K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 10K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 11K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 12K-V Pharmaceutical Company Announces Completion of a $32 Million Private Placement of Class A Common Stock 13Commonly Prescribed Osteoporosis Drug Associated with Very Low Risk of Serious Jaw Disease 2Commonly Prescribed Osteoporosis Drug Associated with Very Low Risk of Serious Jaw Disease 3Commonly Prescribed Osteoporosis Drug Associated with Very Low Risk of Serious Jaw Disease 4
One inch disposable patch electrode uses a specially formulated adhesive solid gel. Reusable lead wire with snap connector provides economic benefits. Ideal for sleep studies where leg movement or EK...
... fabric, these head cap systems are packaged ... testing. Each Electro-Cap System features pure tin ... System. When you place your order, please ... your head cap system and whether you ...
... takes you into the OR, ER, or ICU, ... Cadwells new shielded electrodes. Keeping noise low and ... disc electrode has a special shielded cable that ... effects of 60-cycle interference. That means you get ...
... As opposed to the BIOM, the CWF and ... eye and require a contact medium such as ... to hold a contact lens steady, these lenses ... system. These lenses have an available detachable ...
Medicine Products: