Navigation Links
Changing shape makes chemotherapy drugs better at targeting cancer cells
Date:2/27/2013

(Santa Barbara, Calif. ) Bioengineering researchers at University of California, Santa Barbara have found that changing the shape of chemotherapy drug nanoparticles from spherical to rod-shaped made them up to 10,000 times more effective at specifically targeting and delivering anti-cancer drugs to breast cancer cells.

Their findings could have a game-changing impact on the effectiveness of anti-cancer therapies and reducing the side effects of chemotherapy, according to the researchers. Results of their study were published recently in Proceedings of the National Academy of Sciences.

"Conventional anti-cancer drugs accumulate in the liver, lungs and spleen instead of the cancer cell site due to inefficient interactions with the cancer cell membrane," explained Samir Mitragotri , professor of chemical engineering and Director of the Center for BioEngineering at UCSB. "We have found our strategy greatly enhances the specificity of anti-cancer drugs to cancer cells."

Changing Shape Makes Chemotherapy Drugs Better at Targeting Cancer Cells from UCSB Engineering on Vimeo.

To engineer these high-specificity drugs, they formed rod-shaped nanoparticles from a chemotherapeutic drug, camptothecin, and coated them with an antibody called trastuzumab that is selective for certain types of cancer cells, including breast cancer. The antibody-coated camptothecin nanorods were 10,000-fold more effective than tratsuzumab alone and 10-fold more effective than camptothecin alone at inhibiting breast cancer cell growth.

"This unique approach of engineering shapes of anti-cancer drugs and combining them with antibodies represents new direction in chemotherapy," Mitragotri added.

Mitragotri and collaborators at UCSB, including post-doctoral researchers Sutapa Barua and Jin-Wook Yoo, and former graduate student Poornima Kolhar, looked to human breast cancer cells to examine how shape works in synergy with molecular r
'/>"/>

Contact: Melissa Van De Werfhorst
melissa@engineering.ucsb.edu
805-893-4301
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Avoiding Hospital Readmissions Boot Camp and Survive and Thrive in the Changing Health Care Environment - ABQAURP's 36th Annual Health Care Quality Conference
2. Atlanta Opthalmologist Interviewed About LASIK Surgery’s Life-Changing Effects
3. Panel recommends changing name of common disorder in women
4. Changing Poses LLC Brings Balance to Chiropractic Treatment Tables, Complimentary Lavender Spray Cleaner with All Wholesale Orders
5. Does changing the price of medicine influence consumers perceived health risk?
6. Guidelines developed for extremely premature infants at NCH proven to be life-changing
7. Changing epidemiology of rare disease links sinus irrigation with contaminated tap water, 2 deaths
8. Birds Songs Reflect Changing Weather Patterns: Study
9. Brain structure helps guide behavior by anticipating changing demands
10. Aspen Becomes a Premier CHIME Foundation Member and Supports Vision to Shape the Future of Healthcare through IT Leadership
11. Skechers Injury Lawsuit Filed on Behalf of an Alabama Man Who Suffered Severe Leg Fracture Allegedly Due to Skechers Shape-Ups Toning Shoes, by Wright & Schulte LLC
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Changing shape makes chemotherapy drugs better at targeting cancer cells
(Date:7/12/2014)... Pittsburgh, PA (PRWEB) July 12, 2014 "The ... so it’s uncomfortable and painful to wear shoes," said an ... a special sock that prevents this from happening. , He ... an effective way to prevent the second and big toes ... more endurance while wearing shoes. Ergonomic and easy to use, ...
(Date:7/12/2014)... “After my mom’s stroke, she loss the use of ... the use of his left side. Eating became a difficult task ... people like them enjoy eating again,” said an inventor, from Fayetteville, ... CAROL HALL PLATE (P C H PLATE). , The PATRICIA CAROL ... to eat for individuals who suffer from stroke, experience tremors or ...
(Date:7/12/2014)... New York, New York (PRWEB) July 12, 2014 ... ) continue to move forward in U.S. courts, Bernstein ... that ties elevated metal ion levels to the failure ... the July 2nd issue of The Journal of Bone ... had received unilateral Articular Surface Replacement prostheses at ...
(Date:7/12/2014)... Beverly Hills, CA (PRWEB) July 12, 2014 ... reason why are bodies can readily absorb the nutrients in ... into tiny particles that are small enough to be absorbed ... the DZ10 team, a lack of enzymes in regular food ... DZ10 is a product that was started by Michelle DelPresto, ...
(Date:7/12/2014)... Albany, NY (PRWEB) July 12, 2014 ... to 2020 - New and Late-Stage Four-Factor PCCs ... in-depth analysis of the critical care market in ... and Canada. The report provides an estimation of ... to 2020. It covers critical care indications that ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6
... French . , Recent animal studies have ... used to treat diarrhea and other gastrointestinal disorders ... diseases. Scientists, however, had a variety of theories to ... such similar effects on three unrelated neurodegenerative disorders. , ...
... AMERIGROUP Corporation (NYSE: AGP ) today announced that ... Conference on January 14 in San Francisco.A live broadcast of ... p.m. Eastern Time, can be accessed on AMERIGROUP,s Web site, ... be available for 30 days, and can be accessed at ...
... Jan. 6, Halo Pharmaceutical, Inc., a privately ... completion of its acquisition of the Whippany-NJ Manufacturing ... ABT ). At over 200,000 square feet, ... including an impressive array of formulation services, operations ...
... remain stableWASHINGTON, Jan. 6 Karen Ignagni, President and CEO ... data released by CMS today showing that health spending in ... decade at 6.1 percent in 2007. According to the ... 2007, the same rate as in 2006, but much lower ...
... UCSF has received a $7.5 million grant from the Bill & ... to help address Africa,s urgent need for healthcare workers. , ... ... San Francisco has received a $7.5 million grant from the Bill ...
... With 30 million drivers in the US aged 65 ... they can no longer drive safely and decide that it,s ... that a decrease in vision function is a key factor ... and Driving Study (SEEDS) ( http://www.iovs.org/cgi/content/full/50/1/107 ), conducted by researchers ...
Cached Medicine News:Health News:Old gastrointestinal drug slows aging, McGill researchers say 2Health News:Halo Pharmaceutical, Inc. Acquires Whippany Manufacturing Facility from Abbott 2Health News:Halo Pharmaceutical, Inc. Acquires Whippany Manufacturing Facility from Abbott 3Health News:AHIP Statement on National Health Expenditure Data 2Health News:UCSF and Muhimbili University Launch Initiative to Strengthen Tanzanian Health Workforce 2Health News:UCSF and Muhimbili University Launch Initiative to Strengthen Tanzanian Health Workforce 3Health News:Vision problems prompt older drivers to put down the keys 2
(Date:7/11/2014)... 11, 2014 According to a ... Devices Market (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) ... Forecast, 2013-2019" the global endoscopy devices market was valued ... to grow at a CAGR of 6.8% from 2013 ... 36.9 billion in 2019. Browse the full ...
(Date:7/10/2014)... 11, 2014  Major advances in radiation therapy ... being highlighted in a three-day Oncology Summit taking ... July, 2014.  Renowned national and international cancer experts from ... and exchange knowledge on modern technologies making treatment ... The Summit will address a ...
(Date:7/10/2014)... SAN DIEGO , July 10, 2014  RESMED INC. ... report its fourth quarter and fiscal year ended June 30, ... York Stock Exchange market close. A press release with ResMed,s ... and the company will host a webcast to discuss operating ... scheduled to begin at 1:30 p.m. US Pacific Time and ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... , , STAMFORD, Conn. , Feb. ... subsidiary of Speedus Corp. (Nasdaq: SPDE ), was jointly named ... February 11th—the 163rd birthday of renowned inventor Thomas Alva Edison—at a ... City . Edison created many of the products and technologies taken ...
... , , REDWOOD CITY, Calif. , Feb. ... collaborations in pharmaceutical manufacturing with Dishman Pharmaceuticals and Chemicals ... American Pacific Corporation. These agreements expand the application of ... pharmaceutical products. , Under the new agreements, Codexis ...
Cached Medicine Technology:Zargis Cardioscan Jointly Named as Finalist in 2010 Edison Best New Product Awards 2Zargis Cardioscan Jointly Named as Finalist in 2010 Edison Best New Product Awards 3Codexis Expands Pharmaceutical Manufacturing Partnerships 2Codexis Expands Pharmaceutical Manufacturing Partnerships 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: