Navigation Links
Changing shape makes chemotherapy drugs better at targeting cancer cells
Date:2/27/2013

(Santa Barbara, Calif. ) Bioengineering researchers at University of California, Santa Barbara have found that changing the shape of chemotherapy drug nanoparticles from spherical to rod-shaped made them up to 10,000 times more effective at specifically targeting and delivering anti-cancer drugs to breast cancer cells.

Their findings could have a game-changing impact on the effectiveness of anti-cancer therapies and reducing the side effects of chemotherapy, according to the researchers. Results of their study were published recently in Proceedings of the National Academy of Sciences.

"Conventional anti-cancer drugs accumulate in the liver, lungs and spleen instead of the cancer cell site due to inefficient interactions with the cancer cell membrane," explained Samir Mitragotri , professor of chemical engineering and Director of the Center for BioEngineering at UCSB. "We have found our strategy greatly enhances the specificity of anti-cancer drugs to cancer cells."

Changing Shape Makes Chemotherapy Drugs Better at Targeting Cancer Cells from UCSB Engineering on Vimeo.

To engineer these high-specificity drugs, they formed rod-shaped nanoparticles from a chemotherapeutic drug, camptothecin, and coated them with an antibody called trastuzumab that is selective for certain types of cancer cells, including breast cancer. The antibody-coated camptothecin nanorods were 10,000-fold more effective than tratsuzumab alone and 10-fold more effective than camptothecin alone at inhibiting breast cancer cell growth.

"This unique approach of engineering shapes of anti-cancer drugs and combining them with antibodies represents new direction in chemotherapy," Mitragotri added.

Mitragotri and collaborators at UCSB, including post-doctoral researchers Sutapa Barua and Jin-Wook Yoo, and former graduate student Poornima Kolhar, looked to human breast cancer cells to examine how shape works in synergy with molecular recognition to perform complex tasks within the human body.

"We were inspired to look at the shape as a key parameter by natural objects. In nature, all key particles such as viruses, bacteria, red blood cells, platelets are non-spherical," said Mitragotri. "Their shape plays a key role in their function."

Their research was performed in collaboration with Yatin Gokarn and Aditya Wakankar of Genentech, a member of the Roche group. "The work of Professor Mitragotri and his collaborators exemplifies the groundbreaking contributions bioengineers at UC Santa Barbara are making in medical research, and of how our model of industry partnership delivers results," said Rod Alferness, Dean of the College of Engineering.


'/>"/>

Contact: Melissa Van De Werfhorst
melissa@engineering.ucsb.edu
805-893-4301
University of California - Santa Barbara
Source:Eurekalert  

Related medicine news :

1. Avoiding Hospital Readmissions Boot Camp and Survive and Thrive in the Changing Health Care Environment - ABQAURP's 36th Annual Health Care Quality Conference
2. Atlanta Opthalmologist Interviewed About LASIK Surgery’s Life-Changing Effects
3. Panel recommends changing name of common disorder in women
4. Changing Poses LLC Brings Balance to Chiropractic Treatment Tables, Complimentary Lavender Spray Cleaner with All Wholesale Orders
5. Does changing the price of medicine influence consumers perceived health risk?
6. Guidelines developed for extremely premature infants at NCH proven to be life-changing
7. Changing epidemiology of rare disease links sinus irrigation with contaminated tap water, 2 deaths
8. Birds Songs Reflect Changing Weather Patterns: Study
9. Brain structure helps guide behavior by anticipating changing demands
10. Aspen Becomes a Premier CHIME Foundation Member and Supports Vision to Shape the Future of Healthcare through IT Leadership
11. Skechers Injury Lawsuit Filed on Behalf of an Alabama Man Who Suffered Severe Leg Fracture Allegedly Due to Skechers Shape-Ups Toning Shoes, by Wright & Schulte LLC
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Changing shape makes chemotherapy drugs better at targeting cancer cells
(Date:5/28/2016)... ... ... where’s it’s easy to spot the neon lights of chains serving fast food, one of ... taste for real food. , On May 13, the Best Western Plus Kelowna ... focusing on dishes made by hand with wholesome, organic ingredients that are sourced locally whenever ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of Horizon Blue Cross ... and Industry (TWIN) 2016 honorees. The award recognizes businesswomen who excel in their ... Boone, Director of the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent ... the demand for a sustainable product to aid in the rehabilitation process has steadily ... the recovery of individuals with hemiplegia due to stroke. , Ekso Bionics has now ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, ... ... has partnered with Mediaplanet to help educate the many who are unaware of ... section dedicated to aphasia will run within the “Stroke Awareness” campaign. , The ...
(Date:5/27/2016)... ... 2016 , ... Aimed at nurses and employees in the health care world, ... in the nursing and health care industry. It also provides insight to the developing ... , As the nursing industry is coming out of one of the biggest ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... NASHVILLE, Tenn. , May 26, 2016 ... provider of software and analytics, network solutions ... healthcare, today announced it entered into a ... leading provider of outpatient software solutions and ... surgery centers, specialty hospitals and rehabilitation clinics ...
(Date:5/25/2016)... , May 25,2016 ... the near-infrared Cellvizio platform for urological and surgical ... OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary confocal ... regulatory milestone in the US with the 12 ... and Drug Administration (FDA). This new FDA clearance ...
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 ... bedient dringenden Bedarf zur ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt ... und Entwicklungsvereinbarung mit Therawis Diagnostics GmbH zur Entwicklung ... zu sein. Ein erstes Projekt wird die Entwicklung ...
Breaking Medicine Technology: