Navigation Links
Changing order drugs are taken boosts breast cancer survival
Date:12/7/2011

MAYWOOD, Ill. -- Changing the order in which two drugs are taken significantly extended the lives of women with metastatic breast cancer, a study has found.

Women who took the drugs anastrozole and fulvestrant in combination lived more than six months longer than women who took the drugs in sequence, researchers reported Dec. 7 at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium.

"This most likely will change the standard of care for how we treat these patients," said Kathy Albain, MD, of Loyola University Medical Center, a co-author of the study. First author is Rita Mehta, MD, of the University of California at Irvine.

Anastrozole (brand name, Arimidex) is a pill taken daily. It is in a class of medications called aromatase inhibitors. It works by decreasing the amount of estrogen the body makes. (Estrogen fuels breast cancer.) Fulvestrant (brand name Faslodex) is given by injection. It binds to estrogen receptors, thereby blocking the effect estrogen has on cancer cells.

The study included 707 postmenopausal women who had metastatic breast cancer that was hormone-receptor-positive. About half the women were randomly assigned to receive the standard regimen: treat first with anastrozole, and after the disease progresses, switch to fulvestrant. The other half were randomly assigned to receive anastrozole and fulvestrant in combination.

Women who received the standard regimen survived a median of 41.3 months. Women who received the two drugs in combination survived a median of 47.7 months.

Among women who received the standard regimen, it took a median of 13.5 months for the disease to progress. Among those who received the drugs in combination, it took 15 months before the disease progressed.

The combination treatment produced even greater benefits among women who had not previously taken tamoxifen.

Side effects generally were similar in both treatment groups, although only the combination group experienced the most severe side effects (one stroke and two pulmonary embolisms).
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Twitter Reflects Worlds Changing Moods
2. IU analysis changing diagnosis and management of initial UTIs in young children
3. Changing genetic red light to green holds promise for treating disease
4. Is Social Networking Changing the Face of Medicine?
5. CWRU researchers call for changing how research is done
6. Changing trends in hip fracture incidence around the world
7. Songbirds strategy for changing its tune could inform rehab efforts
8. The changing roles of 2 hemispheres in stroke recovery
9. Changing Parental Behavior May Help Obese Kids Lose Weight
10. Blood-thinning treatment standards changing for heart patients, new research shows
11. Color-changing blast badge detects exposure to explosive shock waves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2017)... City, FL (PRWEB) , ... May 28, 2017 , ... ... be treated with Nerve-Express, the latest Heart Rate Variability (HRV) diagnostic test. , Nerve-Express, ... heart rate and R-R interval, indicating the state of a patient’s autonomic nervous system ...
(Date:5/27/2017)... ... , ... A May 8 article on CBCNews reports that nearly ... that are not responsive to antibiotics nevertheless obtain prescriptions for them. The article goes ... the problem both in Canada and the United States. Dr. Michael Farzam of House ...
(Date:5/26/2017)... ... 26, 2017 , ... Mediaplanet is proud to announce the launch of its ... will educate readers on how to take care of all aspects of their skin. ... on melanoma. Dancing with the Stars professional, Witney Carson, shares her journey with the ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device ... consistent, browser-based interface for diagnostic device operations. With this platform, initializing devices and ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on ... continue to be available at a discounted crowdfunding price on Indiegogo . , ... are, I also wanted to bring a fidget toy to the market that was ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... , May 26, 2017  Endo International plc (NASDAQ: ... President and CEO, will represent the Company in a fireside ... Conference on Tuesday, June 13, 2017 at 10:40 a.m. PT ... Terranea Resort in Rancho Palos Verdes, CA. ... the event will be available on the Company,s website at ...
(Date:5/22/2017)... 22, 2017  Lilac Corp, the company that ... launch of a new website . The ... a clinical study that showed surprising clearance of ... in individuals suffering from HPV warts, precancerous, or ... are no other treatments that clear the virus. ...
(Date:5/15/2017)... , May 15, 2017  Amy Baxter MD, ... industry leader in noninvasive pain relief, was awarded a ... magazine. Baxter was recognized at the MM&M Top ... New York City on May 10, 2017. ... the biopharma industry go "beyond the pill."  ...
Breaking Medicine Technology: