Navigation Links
Changing order drugs are taken boosts breast cancer survival

MAYWOOD, Ill. -- Changing the order in which two drugs are taken significantly extended the lives of women with metastatic breast cancer, a study has found.

Women who took the drugs anastrozole and fulvestrant in combination lived more than six months longer than women who took the drugs in sequence, researchers reported Dec. 7 at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium.

"This most likely will change the standard of care for how we treat these patients," said Kathy Albain, MD, of Loyola University Medical Center, a co-author of the study. First author is Rita Mehta, MD, of the University of California at Irvine.

Anastrozole (brand name, Arimidex) is a pill taken daily. It is in a class of medications called aromatase inhibitors. It works by decreasing the amount of estrogen the body makes. (Estrogen fuels breast cancer.) Fulvestrant (brand name Faslodex) is given by injection. It binds to estrogen receptors, thereby blocking the effect estrogen has on cancer cells.

The study included 707 postmenopausal women who had metastatic breast cancer that was hormone-receptor-positive. About half the women were randomly assigned to receive the standard regimen: treat first with anastrozole, and after the disease progresses, switch to fulvestrant. The other half were randomly assigned to receive anastrozole and fulvestrant in combination.

Women who received the standard regimen survived a median of 41.3 months. Women who received the two drugs in combination survived a median of 47.7 months.

Among women who received the standard regimen, it took a median of 13.5 months for the disease to progress. Among those who received the drugs in combination, it took 15 months before the disease progressed.

The combination treatment produced even greater benefits among women who had not previously taken tamoxifen.

Side effects generally were similar in both treatment groups, although only the combination group experienced the most severe side effects (one stroke and two pulmonary embolisms).

Contact: Jim Ritter
Loyola University Health System

Related medicine news :

1. Twitter Reflects Worlds Changing Moods
2. IU analysis changing diagnosis and management of initial UTIs in young children
3. Changing genetic red light to green holds promise for treating disease
4. Is Social Networking Changing the Face of Medicine?
5. CWRU researchers call for changing how research is done
6. Changing trends in hip fracture incidence around the world
7. Songbirds strategy for changing its tune could inform rehab efforts
8. The changing roles of 2 hemispheres in stroke recovery
9. Changing Parental Behavior May Help Obese Kids Lose Weight
10. Blood-thinning treatment standards changing for heart patients, new research shows
11. Color-changing blast badge detects exposure to explosive shock waves
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... recently awarded their highest ... . , Millions of individuals in the United States and Canada wear eyeglasses. Once ... to both correct vision and make a fashion statement. Even celebrities use glasses as ...
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
(Date:6/23/2016)... Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment ... Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... General Manager of Astellas Farma Colombia ... ...
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
Breaking Medicine Technology: