Navigation Links
Changing order drugs are taken boosts breast cancer survival
Date:12/7/2011

MAYWOOD, Ill. -- Changing the order in which two drugs are taken significantly extended the lives of women with metastatic breast cancer, a study has found.

Women who took the drugs anastrozole and fulvestrant in combination lived more than six months longer than women who took the drugs in sequence, researchers reported Dec. 7 at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium.

"This most likely will change the standard of care for how we treat these patients," said Kathy Albain, MD, of Loyola University Medical Center, a co-author of the study. First author is Rita Mehta, MD, of the University of California at Irvine.

Anastrozole (brand name, Arimidex) is a pill taken daily. It is in a class of medications called aromatase inhibitors. It works by decreasing the amount of estrogen the body makes. (Estrogen fuels breast cancer.) Fulvestrant (brand name Faslodex) is given by injection. It binds to estrogen receptors, thereby blocking the effect estrogen has on cancer cells.

The study included 707 postmenopausal women who had metastatic breast cancer that was hormone-receptor-positive. About half the women were randomly assigned to receive the standard regimen: treat first with anastrozole, and after the disease progresses, switch to fulvestrant. The other half were randomly assigned to receive anastrozole and fulvestrant in combination.

Women who received the standard regimen survived a median of 41.3 months. Women who received the two drugs in combination survived a median of 47.7 months.

Among women who received the standard regimen, it took a median of 13.5 months for the disease to progress. Among those who received the drugs in combination, it took 15 months before the disease progressed.

The combination treatment produced even greater benefits among women who had not previously taken tamoxifen.

Side effects generally were similar in both treatment groups, although only the combination group experienced the most severe side effects (one stroke and two pulmonary embolisms).
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Twitter Reflects Worlds Changing Moods
2. IU analysis changing diagnosis and management of initial UTIs in young children
3. Changing genetic red light to green holds promise for treating disease
4. Is Social Networking Changing the Face of Medicine?
5. CWRU researchers call for changing how research is done
6. Changing trends in hip fracture incidence around the world
7. Songbirds strategy for changing its tune could inform rehab efforts
8. The changing roles of 2 hemispheres in stroke recovery
9. Changing Parental Behavior May Help Obese Kids Lose Weight
10. Blood-thinning treatment standards changing for heart patients, new research shows
11. Color-changing blast badge detects exposure to explosive shock waves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... September 20, 2017 , ... Five consumer packaged goods (CPG) products ... in 27 different categories. Nopavera Plus was named to the short list ... at SupplySide West 2017 during presentations at SupplySide Central on Sept. 27 and 28 ...
(Date:9/20/2017)... ... September 20, 2017 , ... Medicare doesn’t have the authority ... gouging for their prescription drugs, according to a new comparison of drug plans ... our behalf, there’s no consistency in drug pricing among drug plans,” states TSCL’s ...
(Date:9/20/2017)... ... September 20, 2017 , ... Recognising that in ... from Leany Greeny delivers positive results in just three weeks. Setting the groundwork ... the metabolism. Fitting seamlessly into hectic work and family schedules, participants can lose ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... addiction. “RECYCLED Ezekiel's Plan for Freedom from ADDICTION” is the creation of ... in the field of addiction and homeless services, including more than a decade ...
(Date:9/20/2017)... , ... September 20, 2017 , ... Houston, Texas, investment ... took Friday, September 8, and Monday, September 11, off work and rolled up their ... Church before heading to local homes to start the process of rebuilding. , CORDA ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... FRANCISCO , Sept. 12, 2017  ValGenesis ... Management Solutions (VLMS), is pleased to announce the ... a member of its Board of Directors and ... ValGenesis VLMS enables life science companies to manage ... the use of paper in this process. Furthermore, ...
(Date:9/7/2017)... two decades, New Life Agency has been committed to providing the best ... Agency announces a powerful three-way partnership designed to deliver substantial savings on ... ... http://www.schrafts2.com/ (PRNewsfoto/PharmaCareCard) ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ...
(Date:9/6/2017)... Sept. 6, 2017  Robert G. Szewc, M.D., is ... Member in recognition of his contributions to the Medical ... a Nephrologist at the practice of Kidney and Hypertension ... care and hypertension solutions. He has worked in this ... career experience, as well as expertise in kidneys, hypertension, ...
Breaking Medicine Technology: