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Changing epidemiology of rare disease links sinus irrigation with contaminated tap water, 2 deaths

[EMBARGOED FOR AUG. 23, 2012] When water containing the Naegleria fowleri ameba, a single-celled organism, enters the nose, the organisms may migrate to the brain, causing primary amebic meningoencephalitis, a very rarebut usually fataldisease. A new study published in Clinical Infectious Diseases describes the first reported cases in the United States implicating nasal irrigation using disinfected tap water in these infections. Now available online, the study highlights the changing epidemiology of this uncommon disease, as well as the importance of using appropriately treated water for nasal irrigation.

From 2002 to 2011, 32 N. fowleri infections were reported in the U.S., according to the Centers for Disease Control and Prevention (CDC). In this latest study, Jonathan Yoder, MPH, coordinator of waterborne diseases and outbreak surveillance at CDC, reports the work of the Louisiana Department of Health and Hospitals and CDC in investigating two cases in 2011 in Louisiana. Two unrelated patients, a 28-year-old man and a 51-year-old woman, each died within five days of being admitted to the hospital with meningitis-like symptoms. Both had used a neti pot for regular sinus irrigation. Because family members of both patients were certain the patients had no recent history of recreational freshwater contact, which is typically associated with the disease, sinus irrigation using disinfected (chloraminated) tap water was implicated.

"N. fowleri was found in water samples from both homes," Yoder said, but "not found in the treatment plants or distribution systems of the municipal water systems servicing the patients' homes." Although it was never clear how N. fowleri were introduced into the plumbing of the patients' houses, once there, the organisms were able to colonize the hot water systems.

In addition, Yoder's team also tested commercially available reconstituted salt packets for use with neti pots and found that these were unable to reduce the number of N. fowleri organisms within a four-hour timeframefar outside the real world conditions of less than a minute that most people spendshowing that simply adding salt mixtures to tap water does not inactivate the organisms fast enough. As a result, Yoder advises that the simplest methods to avoid infection is to purchase water that is labeled as distilled or sterile, or use only water that was previously boiled for 1 minute (at elevations above 6,500 feet, boil for 3 minutes) that has been left to cool, or use water that has gone through a filter with a pore size of 1 micron or smaller.

Many infections from N. fowleri occur in warm freshwater locations following localized heat waves. Whether projected climate change could lead to an expansion of the ameba's geographic range is unknown, the authors noted. They recommend that systematic environmental sampling be carried out to document changes in the ecology of N. fowleri so that measures to prevent its spread can be improved. It is also important to raise the level of awareness about the disease among physicians treating patients with meningitis-like symptoms, the authors wrote.

Deaths from N. fowleri infection, which remain very rare, "are tragic for the families of those infected," Yoder said. "The CDC is working to understand this organism so that we can improve prevention recommendations, identify N. fowleri infections, and improve clinical treatment."

Fast Facts

  1. Primary amebic meningoencephalitis is a very rare but usually fatal disease caused when water containing Naegleria fowleri amebae enters the nose, allowing the single-celled organisms to migrate to the brain.
  2. In 2011, two fatal cases of the disease reported from Louisiana occurred in persons following nasal irrigation. This is the first time that contaminated tap water coming from a disinfected municipal water system has been linked to N. fowleri infections in the United States.
  3. For prevention, health officials advise using only previously boiled, filtered, distilled, or sterilized water when making solutions for irrigating, flushing, or rinsing the sinuses.


Contact: Laurel White
Infectious Diseases Society of America

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