Navigation Links
Changing 'channels' to eliminate chronic pain
Date:4/26/2010

In most cases of chronic pain lingering pain that never seems to go away after accidents or prolonged illnesses ― no pill exists to dull the hurt. Billions of dollars are lost every year in sick days taken to alleviate chronic pain, and as much money is spent by the healthcare system to diagnose what's wrong.

Dr. Joel Hirsch of Tel Aviv University conducts basic research investigating calcium channels in the human body, established targets for the alleviation of chronic pain. His research, recently presented at the Biophysical Society in San Francisco, provides new information into how these channels work. His laboratory is developing computer-derived models of drugs that might affect chronic pain ― such as pain from backaches, sore limbs and arthritis ― which are targeted for calcium channels.

"We have determined structures of calcium channel components which provide a framework for drug design and targeting," Dr. Hirsch says. "There is still much to learn about calcium channels, which enable pain signals to travel from the body to the brain."

Once he and his colleagues understand the deeper mechanisms of these channels, they hope to use new drugs to modulate them "on" and "off" as needed ― and provide relief to the millions of people who suffer from the condition.

Finding where it hurts

According to the American Chronic Pain Association, chronic pain is pain that persists a month or more beyond the usual recovery period for an injury or illness. It can continue for months or years, is not always constant, but usually interferes with one's quality of life at all levels.

Three drugs on the market target calcium channels for pain indications such as Lyrica, Neurotonin and ziconitide. But they are not effective in many cases, while ziconitide requires an injection into the spine. Hence, there is a considerable need for alternative drugs.

"Calcium channels are still poorly understood, but we do know that they are also important players in pathways that cause epilepsy. Our research into neuropathy, or finding treatments for chronic pain, may yield a new class of compounds that serve multiple purposes," says Dr. Hirsch. "Our challenge is to target calcium channel modulators to specific tissues or channel types a single drug for all forms of chronic pain isn't likely.

"There are literally millions of people that already take calcium channel blockers for angina and hypertension. More research on how this family of channels works could yield a new kind of drug for a specific subfamily of these channels," Dr. Hirsch concludes.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Related medicine news :

1. IABC Cleveland Presents The Changing Face of Health Care Communications at Feb. 18 Luncheon
2. Reportlinker Adds Emerging Clinical Trial Locations - India: Market Dynamics and the Changing Healthcare and Regulatory Environment
3. While Some Were Counting Sugar Plums...Others Were Changing the Future
4. After the Holidays Families Recognize Changing Needs of Aging Parents and Loved Ones
5. Changing the Course of Kids Health
6. ChangingHomeCare.com Launches Effort to Promote Future of Homecare
7. Savor: Mindful Eating, Mindful Life -- The Definitive Guide to Changing the Way People Eat and Live
8. New Report: The Internet Has More Influence Over Consumer Health Actions than Traditional DTC Channels
9. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
10. Medicare Eliminates Consultation Codes for Doctors
11. Why does percutaneous endoscopic gastrostomy fail to eliminate gastroesophageal reflux?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
Breaking Medicine Technology: