Navigation Links
Changing cancer's environment to halt its spread
Date:5/21/2013

d non-metastatic tumors induce cells from the bone marrowspecifically, monocytes expressing the Gr1 surface markerto migrate to the lungs. However, non-metastatic tumors then trigger these monocytes to produce thrombospondin-1 by releasing prosaposin.

"Others have shown that tumors recruit monocytes to future metastatic sites, which help to set up a permissive environment for tumor cells to metastasize, " Watnick notes. "Our results suggest that non-metastatic tumors do the same thing, but instead of creating a permissive environment, the monocytes create a refractory environment by producing thrombospondin-1."

Watnick thinks this finding creates a window of therapeutic opportunity. "If we can trigger monocytes recruited by pro-metastatic tumors to produce thrombospondin-1 like those recruited by non-metastatic tumors, we will be able to hijack the mechanism by which tumors create metastasis-permissive sites to close the door on those sites."

Thrombospondin-1 itself, however, is too large to serve as a drug, and studies using shortened versions of the protein have not been promising. Watnick and his collaborators instead are focusing on prosaposin. To find the smallest part of prosaposin capable of activating thrombospondin-1, the team took an 80-amino acid region of prosaposin and whittled it down bit by bit until they isolated a five amino-acid peptide that could trigger thrombospondin-1 production as strongly as the full-length protein.

When administered in mouse models of metastatic cancer, this peptide significantly reduced metastasis compared to scrambled versions of the peptide (with the same amino acids but in different sequence), but only in mice with monocytes capable of producing thrombospondin-1.

Strikingly, Watnick and his collaborators also found that prostate cancer patients whose tumors expressed higher levels of prosaposin had significantly greater overall survival than patients whose tumors express
'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Boston Children's Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Brain structure helps guide behavior by anticipating changing demands
2. Birds Songs Reflect Changing Weather Patterns: Study
3. Changing epidemiology of rare disease links sinus irrigation with contaminated tap water, 2 deaths
4. Guidelines developed for extremely premature infants at NCH proven to be life-changing
5. Does changing the price of medicine influence consumers perceived health risk?
6. Changing Poses LLC Brings Balance to Chiropractic Treatment Tables, Complimentary Lavender Spray Cleaner with All Wholesale Orders
7. Panel recommends changing name of common disorder in women
8. Atlanta Opthalmologist Interviewed About LASIK Surgery’s Life-Changing Effects
9. Avoiding Hospital Readmissions Boot Camp and Survive and Thrive in the Changing Health Care Environment - ABQAURP's 36th Annual Health Care Quality Conference
10. Changing shape makes chemotherapy drugs better at targeting cancer cells
11. New data show countries around the world grappling with changing health challenges
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... In the past few weeks, TheBeautyPlace.com has been undergoing ... to run maintenance on our shipping facilities to update ... PR Director. "It disrupted our regular shipping schedule but ... on track after having completed the maintenance." , Now, ... which has not allowed some calls to come in ...
(Date:4/18/2015)... April 18, 2015 “ ArcAngel ” was ... takes a look at the latest and coolest ... Troohey, the host of AppWatch and technology expert, conducted the ... personal safety app. , In a turbulent world, people ... Calling 911 should always be their first move, but some ...
(Date:4/17/2015)... 17, 2015 John Evans, a Gardant ... the Patio from 2 p.m. to 3 p.m. on ... 1320 Executive Ct. in Pekin, Illinois, serves older adults ... some help to maintain their independence. , Becky Baker ... treats will be served during the luau. , For ...
(Date:4/17/2015)... Oklahoma (PRWEB) April 17, 2015 Alcohol ... Drug Dependence (NCADD) notes that drinking and driving has ... At the same time, the link between alcohol ... as domestic abuse and violence and sexual assault, and ... According to the NCADD, 5.3 million adults in America ...
(Date:4/17/2015)... In Defense of Christians (IDC) Executive ... Wednesday April 15th, the European Parliament joined its voice ... the Armenian Genocide, “paying tribute, on the eve of ... innocent Armenian victims who perished in the Ottoman Empire.” ... for this timely and needed recognition of a tragic ...
Breaking Medicine News(10 mins):Health News:TheBeautyPlace.com Temporary Number Available 2Health News:A Personal Safety Application was Featured on NewsWatch Television 2Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3Health News:In Defense of Christians Condemns Armenian Genocide 2Health News:In Defense of Christians Condemns Armenian Genocide 3
... taken ill Wednesday after inhaling methane gas leaking from a colliery ... leak was reported early morning from the Bathdih colliery of Bharat ... ,The 10 people of Barari Basti area who fell ... to be in critical condition. ,BCCL officials have rushed ...
... the ghastly video.,A slender girl dragged along by her headlocks, on ... a torrent, then her head is smashed with a concrete ... then victorious shouts are heard. ,In the eyes ... Duaa Khalil Aswad, 17, was to love a boy from another ...
... Administration (FDA) has approved the first birth control pill ... monthly preparation of pregnancy. ,Lybrel, produced ... a low dosage of hormones ethinyl estradiol and levonorgestrel, ... pill prevents conception by halting menstrual period indefinitely. ...
... at the Albert Einstein College of Medicine in Yeshiva ... ability to use radioactivity as an energy source ... ,According to Dr. Arturo Casadevall, chair of microbiology and ... this finding could trigger a recalculation of the Earth's ...
... Sipping tea is far better than drinking water, researchers said. ... three or more cups of tea can reduce the risk ... Carrie Ruxton from King's College London, it is a wrong ... better than water as it contains antioxidants. It does not ...
... of the state-run super speciality SSKM Hospital in Kolkata was ... during a medical test Tuesday night. ,"We ... charges of outraging the modesty of this 32-year-old lady during ... told IANS. ,"A complaint was lodged by the ...
Cached Medicine News:Health News:Women in Iraq More Unsafe Than Ever 2Health News:Astronauts can Now Feed on 'radiation-eating' Fungi 2
(Date:4/17/2015)... , April 17, 2015 TWi Pharmaceuticals, Inc. ... TWi Pharmaceuticals USA , has obtained ... United States.  It has been in close contact with ... expects to have its own label specialty generic products ... the U.S. pharma market. According to IMS ...
(Date:4/16/2015)... , April 16, 2015 A drug commonly taken ... of people with multiple sclerosis (MS), according to a study ... of Neurology,s 67th Annual Meeting in Washington, DC ... "About half of people with MS experience at some point ... which the nerve carrying vision from the eye to the ...
(Date:4/16/2015)... , April 16, 2015  Amgen (NASDAQ: AMGN ... quarter financial results on Tuesday, April 21, 2015, after ... will be followed by a conference call with the ... call from Amgen will be Robert A. Bradway ... of Amgen,s senior management team. Live audio ...
Breaking Medicine Technology:Epilepsy Drug May Preserve Eyesight for People with MS 2Amgen Announces Webcast Of 2015 First Quarter Financial Results 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: