Navigation Links
Changes seen in cerebrospinal fluid levels before onset of Alzheimer dementia

CHICAGO Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to be later markers of disease, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

The researchers note as background in the study that disease-modifying therapies, such as immunotherapy, are more likely to be successful if started in the early stages of the disease so there is a need to identify patients with Alzheimer disease before neurodegeneration is not too severe.

Peder Buchhave, M.D., Ph.D, who is affiliated with Lund University and Skane University, Sweden, and colleagues conducted an extended follow-up of the cohort from a previous study of 137 patients with mild cognitive impairment (MCI) at baseline. The median follow-up was 9.2 years.

During the follow-up, 72 patients (53.7 percent) developed AD and 21 (15.7 percent) progressed to other forms of dementia. At the baseline, cerebrospinal fluid Aβ42 levels were reduced and other biomarkers T-tau and P-tau levels were elevated in patients who converted to AD during follow-up compared with levels in patients who did not develop AD.

The study indicates baseline CSF Aβ42 levels were equally reduced in patients with MCI who converted to AD within five years (the early converters) compared to those who converted later between five and 10 years. However, T-tau and P-tau levels were significantly higher in early converters compared to later ones.

Researchers suggest that "approximately 90 percent of patients with MCI and pathologic CSF biomarkers at baseline will develop AD within 9.2 years."

"Therefore, these markers can identify individuals at high risk for future AD least five to 10 years before conversion to dementia. Hopefully, new therapies that can retard or even halt progression of the disease will soon be available. Together with an early and accurate diagnosis, such therapies could be initiated before neuronal degeneration is too widespread and patients are already demented," the authors conclude.


Contact: Oskar Hansson, M.D., Ph.D.
JAMA and Archives Journals

Related medicine news :

1. Changes in Cerebrospinal Fluid May Signal Early Alzheimers
2. Multiple Sclerosis May Cause Changes in Thalamus: Study
3. Ecstasy May Cause Long-Term Changes in Brain Chemistry
4. Brain Changes May Be Tied to Parkinsons Dementia
5. Taxi Drivers Show How Learning Changes Adult Brain
6. Researchers discover that changes in bioelectric signals cause tadpoles to grow eyes in back, tail
7. Drug reverses aging-associated changes in brain cells
8. Children experience differing changes one year after a siblings death from cancer
9. ADHD Brain Changes Appear to Persist Into Adulthood
10. U.S. Health Officials Urge Lifestyle Changes to Cut Stroke Risk
11. Pot Can Mimic Brain Changes Seen in Schizophrenia
Post Your Comments:
(Date:11/24/2015)... Leamington, ON (PRWEB) , ... November 24, 2015 , ... ... Innovations with Ed Begley Jr., airing first quarter 2016 via Discovery Channel. Dates and ... laws of the Province, and is in the business of producing and supplying medical ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... that the organization will waive paid entry and parking fees at several of ... and Monument Mountain in Great Barrington in support of REI’s Black Friday #OptOutside ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... share their knowledge and experiences at a live taping of the next ... for the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel & ...
(Date:11/24/2015)... R.I. (PRWEB) , ... November 24, 2015 , ... With ... Amica Insurance is sharing safety tips to help protect your family and vehicle. , ... crashes around the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips ...
(Date:11/24/2015)... ... November 24, 2015 , ... Chiropractic student Katie ... (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester student in the university’s ... Cleveland III on October 16. , “Katie is very excited and greatly appreciative ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Solutions, Inc. (Pink Sheets: ASDS ) ("Ascendant" or the ... a special 1 percent stock dividend on the company,s common ... to shareholders of record December 7, 2015.  The dividend will ... stock. --> --> ... our confidence in Ascendant,s growth strategy as well as the ...
(Date:11/24/2015)... 24, 2015  Figure 1, a free mobile-first network ... cases, has launched a new completely redesigned web version ... allows radiologists, who work primarily on a desktop, to ... with its radiologist user base, Figure 1 is hosting ... North America (RSNA) Annual Meeting. ...
(Date:11/24/2015)... BEACH, Fla. , Nov. 24, 2015 /PRNewswire/ ... , has recently announced the launch of their ... --> ... --> --> ... for during travel and vacation, just got a ...
Breaking Medicine Technology: