Navigation Links
Changes in nerve cells may contribute to the development of mental illness
Date:11/28/2012

Reduced production of myelin, a type of protective nerve fiber that is lost in diseases like multiple sclerosis, may also play a role in the development of mental illness, according to researchers at the Graduate School of Biomedical Sciences at Mount Sinai School of Medicine. The study is published in the journal Nature Neuroscience.

Myelin is an insulating material that wraps around the axon, the threadlike part of a nerve cell through which the cell sends impulses to other nerve cells. New myelin is produced by nerve cells called oligodendrocytes both during development and in adulthood to repair damage in the brain of people with diseases such as multiple sclerosis (MS).

A new study led by Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomics; and Neurology at Mount Sinai, determined that depriving mice of social contact reduced myelin production, demonstrating that the formation of new oligodendrocytes is affected by environmental changes. This research provides further support to earlier evidence of abnormal myelin in a wide range of psychiatric disorders, including autism, anxiety, schizophrenia and depression.

"We knew that a lack of social interaction early in life impacted myelination in young animals but were unsure if these changes would persist in adulthood," said Dr. Casaccia, who is also Chief of the Center of Excellence for Myelin Repair at the Friedman Brain Institute at Mount Sinai School of Medicine. "Social isolation of adult mice causes behavioral and structural changes in neurons, but this is the first study to show that it causes myelin dysfunction as well."

Dr. Casaccia's team isolated adult mice to determine whether new myelin formation was compromised. After eight weeks, they found that the isolated mice showed signs of social withdrawal. Subsequent brain tissue analyses indicated that the socially isolated mice had lower-than-normal levels of myelin-forming oligodend
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Teen Drinking May Boost Odds of Precancerous Breast Changes
2. Changes in gene expression may help explain high blood pressure in pregnancy
3. Brain Changes May Hamper Decision-Making in Old Age
4. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
5. Molecular probes identify changes in fibronectin that may lead to disease
6. Dietary changes help some children with ADHD
7. Palliative care resource helps ease changes
8. Chronic cocaine use triggers changes in brains neuron structure
9. Eye Changes May Predict Heart Disease in Blacks With Diabetes
10. From One Generation to the Next, Dental Care Changes
11. Tiny Tots in the Dentists Chair Among Changes in Pediatric Dentistry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... made from the wonder material graphene has been used ... developing cancer. , The biosensor has been shown ... bioassay tests currently in use, and was able to ... the possibility of a rapid, point-of-care diagnostic tool for ... September, in IOP Publishing,s journal 2D Materials . ...
(Date:9/19/2014)... 2014 Follow us on LinkedIn ... medical imaging market, are engineered to enhance the anatomic ... past three decades have expanded the application roles of ... based agents used for over half a century to ... agents have witnessed sea changes, revolutionizing in the process ...
(Date:9/19/2014)... 2014 The Nordic ... style of eating, is making its way ... Doc’s medical weight loss programs, ... good food which leads to improved health. ... patients to understand how diet can impact ...
(Date:9/19/2014)... Recent financial data reveled ... their sales by 7% in the last quarter of ... can be used as a bellwether to determine how ... data has been proven to show trends with shipments ... Other non-trucking data is largely influenced by international and ...
(Date:9/19/2014)... Baltimore, MD & Salt Lake City, UT (PRWEB) September ... pleased to launch the new Activz Greens Smoothie ... Natural Products Expo East, September 18th-20th in Baltimore, ... powder with 8 organic super foods combined in one ... at Natural Products Expo East, September 18th-20th in Baltimore, ...
Breaking Medicine News(10 mins):Health News:Graphene sensor tracks down cancer biomarkers 2Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 2Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 3Health News:New Clinical Applications and Advanced Imaging Capabilities Drive Growth in the Imaging Agents Market, According to New Report by Global Industry Analysts, Inc. 4Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 2Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 3Health News:Diet Doc’s Medical Weight Loss Programs Announce Diet Plans Based on the Same Principles as the New Nordic Diet 4Health News:LeaseQ Announces Good News For The Truck Leasing Industry As Truck Rentals In The U.S Continues to Gain Traction 2Health News:LeaseQ Announces Good News For The Truck Leasing Industry As Truck Rentals In The U.S Continues to Gain Traction 3Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 2Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 3
... kidney disease arent referred to kidney specialists in time ... a variety of reasons, according to researchers at Wake ... An analysis of 18 separate studies found that overall, ... and suffering from multiple health problems are patient characteristics ...
... Minn. -- The incidence of type 2 diabetes is ... sedentary lifestyles and obesity abound. In addition to weight ... for developing type 2 diabetes. The incidence of diabetes ... highest prevalence. An estimated 32 million Asian Indians have ...
... NEW YORK, Feb. 29 Philips Electronics (PHG) on ... its kind, during,a media tour of the new Mercy ... doors on March 16., , (See video from ... The canvas, displayed in the Women,s and Children,s waiting ...
... PRINCETON, N.J., Feb. 29 Richard P. Miller,of Marlton, ... was,installed as chairman of the board of the New ... official,installation, as well as the appointment of new board ... Hyatt Regency Princeton., "As we look to the ...
... LLC, a,Minneapolis-based privately-held holdings company, has launched ... experienced,interim and contract resources to Minneapolis-St. Paul ... breakthrough in one of the key problems ... Norbom, President and,Founder of Vallon LifeScience. "...how ...
... 2008 Official Shoes are Now On Sale, WHITE PLAINS, ... with Famous Footwear(TM) and Dr. Scholl,s(R) to,introduce the 2008 Official ... year, Famous Footwear and Dr. Scholl,s are,raising funds for March ... specially designed one men,s and two women,s athletic shoes to,be ...
Cached Medicine News:Health News:Study identifies reasons patients referred late to nephrologists 2Health News:Mayo researchers look for explanation behind high incidence of diabetes among Asian Indians 2Health News:Mayo researchers look for explanation behind high incidence of diabetes among Asian Indians 3Health News:VIDEO from Medialink and Philips: Philips Electronics Unveils First 'Imagination Light Canvas' at the New Mercy Medical Center in Rogers AR 2Health News:New Jersey Hospital Association Names New Chairman, Appoints Board Officers and New Members 2Health News:Vallon Holdings, LLC Launches New Subsidiary Focused on Contract Resources for the Minneapolis-St. Paul Life Science Industry 2Health News:Famous Footwear, Dr. Scholl's Step Up to Support March for Babies 2008 2
(Date:9/19/2014)... , Sept. 19, 2014  Diplomat, the nation,s largest ... David Dreyer to the Board of Directors on ... and will also serve as chair of the Audit ... years of accounting, financial, compliance and operating experience in ... has served as chief financial officer, chief operating officer ...
(Date:9/19/2014)... Sept. 19, 2014 Larry J. Merlo , ... ), will speak before the National Press Club in ... company,s recent move to stop selling tobacco products and its ... of health. "Dramatic changes in our health care ... and government," Merlo has said. "CVS Health has a truly ...
(Date:9/19/2014)... 19, 2014  Pressure BioSciences, Inc. (OTCQB: PBIO) ... received and approved all parts required to build ... begun to manufacture the new PCT-based instrument system.  ... ready for shipment by mid-October and that additional ... a rate of about one per week thereafter.  ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3
... CHICAGO, March 7, 2012  UHC, an alliance of the ... of a mobile application for Rx LINK ™ , ... insight into their pharmacy price performance. The mobile app ... can be accessed on an Apple iPad. ...
... Drug Discovery Foundation (ADDF) and the Association for ... their fifth annual research award, Frontotemporal Degeneration ... of the program is to accelerate the development ... The ADDF/AFTD program awarded $300,000 to ...
Cached Medicine Technology:UHC Launches RxLINK(TM) Mobile App to Deliver Instant Data Access for Strategic Pharmacy Purchasing 2UHC Launches RxLINK(TM) Mobile App to Deliver Instant Data Access for Strategic Pharmacy Purchasing 3Awards for Drug Discovery Research for Frontotemporal Degeneration Announced 2Awards for Drug Discovery Research for Frontotemporal Degeneration Announced 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: