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Changes in hyaluronan metabolism key in adaptation of keratinocytes to radiation injury
Date:7/2/2013

lly on the Has3 enzyme. Blocking its expression with a specific siRNA reversed the UVB-induced hyaluronan production nearly to the level of the control cells. The results thus strongly indicate that epidermal keratinocytes exposed to UVB specifically activate their hyaluronan synthesis by regulating the HAS-enzymes via at least two different signalling pathways. This may be one mode for the cells to adapt to radiation damage.

Even though more research is warranted, the new data further our understanding about the significance of hyaluronan for keratinocyte function under environmental stress. This activation of hyaluronan metabolism after excessive UVB exposure may also prove to be a target for regulation when trying to control and understand tissue malignancy and pre-cancerous alterations.


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Contact: Leena Rauhala
leena.rauhala@uef.fi
358-503-871-326
University of Eastern Finland
Source:Eurekalert

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