Navigation Links
Changes in gene expression may help explain high blood pressure in pregnancy
Date:4/13/2012

RICHMOND, Va. (April 12, 2012) Virginia Commonwealth University School of Medicine researchers have discovered that changes in the gene expression of a key enzyme may contribute to high blood pressure and increase susceptibility to forming blood clots in pregnant women with preeclampsia.

These findings could provide clues to the best treatment approaches for high blood pressure and the formation of blood clots that can block blood flow to a pregnant woman's internal organs and lead to organ failure.

Researchers have been working to determine the root cause of preeclampsia on the molecular level and have now identified that epigenetic mechanisms may be at play. Epigenetics refers to changes in gene expression that are mediated through mechanisms other than changes in the DNA sequence.

In a study published online this week in Hypertension, a journal of the American Heart Association, the VCU team reported that thromboxane synthase an important inflammatory enzyme is increased in the blood vessels of expectant mothers with preeclampsia. The thromboxane synthase gene codes for this enzyme, which is involved in several processes including cardiovascular disease and stroke. This enzyme results in the synthesis of thromboxane, which increases blood pressure and causes blood clots.

"The present work is unique because it opens up a new concept as to the cause and subsequent consequences of preeclampsia relating to epigenetics," said corresponding author Scott W. Walsh, Ph.D. , professor in the VCU Department of Obstetrics and Gynecology . "It is the first study to show that epigenetic alterations in the blood vessels of the mother are related to preeclampsia."

According to Walsh, one of the main epigenetic mechanisms is methylation of the DNA, which controls the expression of genes. The increase of this enzyme in the blood vessels is related to reduced DNA methylation and the infiltration of neutrophils int
'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Physical Changes in Brain Linked to Altered Spirituality
2. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
3. Medicare Advantage Members May Make Changes During Open Enrollment
4. CMS Watch Changes Name to The Real Story Group
5. Changes during menopause increases risk of heart disease and stroke
6. Childhood stress such as abuse or emotional neglect can result in structural brain changes
7. Dmatek Changes its Name to Attenti
8. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
9. YourHCG.com Changes the Way People Lose Weight by Offering an Affordable HCG Diet Plan
10. Small Nutritional Changes are a Key to Health, Weight Loss, says DSM Personalized Nutrition
11. Canadian Cattle Producers Willing to Make Changes to Prevent E. coli O157 Contamination on their Farms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... mesh lawsuits are moving along in the New Jersey state ... handle evidence in the C.R. Bard lawsuits, specifically focusing on ... from patients. The Rottenstein Law Group LLP maintains a ... device and a guide on how to file a lawsuit. ... facilities that currently hold them and are to maintain them ...
(Date:6/19/2013)... June 19, 2013 Anant Goel, CEO at ... changing rapidly. The first industrial revolution began in Britain in ... industry… when the factory was born. The second industrial revolution ... the moving assembly line and ushered in the age of ... the 21st century. Manufacturing is going digital and this could ...
(Date:6/19/2013)... 2013 Men often deal with gastrointestinal health ... attention to what they are consuming on a daily basis. ... producer and supplier of Siberian pine nut oil, PineNutOil.org ... all-natural healing elements within pine nut oil. , ... common ulcers within the gastrointestinal tract that are usually acidic ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Recovery Associates, ... upon crystal meth addiction treatment, helping men and women ... drug. , Crystal meth is a stimulant named for ... drug is most commonly smoked, but it can also ... commonly created in homemade labs using common household ingredients ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Best Halfway House ... giving people a chance to keep on their road of ... provides a menu of selections for sober houses for men ... uses in their network need to meet certain criteria. They ... considered. The houses must have structure and accountability measures in ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: NJ Mesh Consolidation Cases Moving Along, Rottenstein Law Group LLP Reports 2Health News:RKNet Studios Announced Cognitions Bridge Intelligence Games for Fun, Cognitive Skills Testing and Development for Success in Life 2Health News:RKNet Studios Announced Cognitions Bridge Intelligence Games for Fun, Cognitive Skills Testing and Development for Success in Life 3Health News:RKNet Studios Announced Cognitions Bridge Intelligence Games for Fun, Cognitive Skills Testing and Development for Success in Life 4Health News:Pine Nut Oil is a Proven Remedy for Stomach Ulcers 2Health News:Crystal Meth Addiction Treatment and Crystal Meth Drug Rehab Announced by Recovery Associates 2Health News:Pensacola, Florida Joins Best Halfway House Recovery Network, Providing Resources for Those Seeking to Further Their Recovery from Drug and Alcohol Addiction 2
... BioCryst,Pharmaceuticals (Nasdaq: BCRX ) today announced that ... Thursday, May 8, 2008. At 8:30 a.m.,Eastern Time BioCryst ... financial results and provide an update on the Company,s ... by Jon P. Stonehouse,BioCryst,s Chief Executive Officer, and Stuart ...
... procedures were done at an unlicensed clinic in North ... News) -- Three women who received derriere-enhancing injections at ... after the procedure. , Not only was the facility ... not medically supervised, and investigators later could not even ...
... Campaign Encourages Illinois Residents to Say it out loud, ... one,in five Illinois residents is experiencing a mental health ... was launched today to promote,good mental health and to ... it out loud. The campaign seeks to promote good ...
... A new analysis from the,Lewin Group underscores ... nation,s economic activity. In reacting to the data, ... cuts,expected in a forthcoming Centers for Medicare and ... just to the care of America,s frail,elderly and ...
... NEW YORK, May 1 In 2007, patients in ... prescription on 550 million separate,occasions. Millions then made two ... drop off the prescription and another to pick it ... can choose to,have their prescription electronically transmitted to the ...
... SCI ) announced it expects to issue a press release,with financial ... the market closes. A conference call will be hosted by SCI,Management ... as,follows:, What: Service Corporation International First ... Conference Call, When: Thursday, May ...
Cached Medicine News:Health News:BioCryst Pharmaceuticals to Announce First Quarter 2008 Financial Results on May 8, 2008 2Health News:BioCryst Pharmaceuticals to Announce First Quarter 2008 Financial Results on May 8, 2008 3Health News:3 Women Suffer Kidney Failure After Derriere Injections 2Health News:3 Women Suffer Kidney Failure After Derriere Injections 3Health News:3 Women Suffer Kidney Failure After Derriere Injections 4Health News:Making It Easier to Talk About Mental Health 2Health News:Making It Easier to Talk About Mental Health 3Health News:Making It Easier to Talk About Mental Health 4Health News:New Lewin Group Analysis: Medicare Cuts for Nursing Facility Care Could Have Economic Impact Up to $4.2 Billion, Threaten Jobs 2Health News:VIDEO from Medialink and SureScripts: Does Your Doctor Still Use Paper Prescriptions? 2Health News:Service Corporation International Announces Schedule for Its First Quarter 2008 Earnings Release and Conference Call 2
(Date:6/18/2013)... , June 18, 2013 Decision Resources, one of ... healthcare issues, finds that, over the past 12 months, 25 ... , Germany , Italy ... United Kingdom ) have been required to change ... HIV patients, primarily to reduce costs. Additionally, more than 40 ...
(Date:6/18/2013)... -- Today, Wall Street Reports announced new research ... Health Management Associates Inc. (NYSE: HMA ), IDEXX ... (NASDAQ: ISIS ), and Trius Therapeutics Inc. (NASDAQ: ... - including full price targets, industry analysis and analyst ratings ... Research Report On June 7, 2013, Gilead Sciences ...
(Date:6/18/2013)... Calif. , June 18, 2013 ... focused on the development of next-generation atrial fibrillation ... No. 8295902 by the US Patent and Trademark ... encompasses low profile electrode assemblies for use on ... ablation or other surgical procedures. "We ...
Breaking Medicine Technology:One in Four Surveyed EU5 Physicians Has Been Required to Change a Prescription for Some or Most of Their HIV Patients in the Past Twelve Months, Primarily to Reduce Costs 2One in Four Surveyed EU5 Physicians Has Been Required to Change a Prescription for Some or Most of Their HIV Patients in the Past Twelve Months, Primarily to Reduce Costs 3Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 2Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 3Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 4Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 5Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 6
... TOKYO , February 9 ... 31, 2009 .,Net sales were 106.8 billion yen for the ... period last year. Operating income was 18.9 billion,yen , a 13.8% ... year,mainly due to increase in orders and productivity. Compared to the second,quarter ...
... , UITHOORN, The Netherlands , February ... (49) as CEO of Hoya Vision Care,Europe starting the 1st of ... who has been leading the European branch in the past 5 years. ... Mr. Werquin has 20 years experience in the optical industry ...
Cached Medicine Technology:Hoya Announces Third Quarter Financial Results 2New CEO for Hoya Vision Care Europe 2
Blunt Weitlaner Retractor....
Weitlaner Beckmann retractor, sharp prongs, SS....
Baby Weitlaner retractor, blunt, 4"....
Scoville sharp curette, 10, straight, scoop size 4 x 10 mm....
Medicine Products: