Navigation Links
Changes in gene expression may help explain high blood pressure in pregnancy
Date:4/13/2012

RICHMOND, Va. (April 12, 2012) Virginia Commonwealth University School of Medicine researchers have discovered that changes in the gene expression of a key enzyme may contribute to high blood pressure and increase susceptibility to forming blood clots in pregnant women with preeclampsia.

These findings could provide clues to the best treatment approaches for high blood pressure and the formation of blood clots that can block blood flow to a pregnant woman's internal organs and lead to organ failure.

Researchers have been working to determine the root cause of preeclampsia on the molecular level and have now identified that epigenetic mechanisms may be at play. Epigenetics refers to changes in gene expression that are mediated through mechanisms other than changes in the DNA sequence.

In a study published online this week in Hypertension, a journal of the American Heart Association, the VCU team reported that thromboxane synthase an important inflammatory enzyme is increased in the blood vessels of expectant mothers with preeclampsia. The thromboxane synthase gene codes for this enzyme, which is involved in several processes including cardiovascular disease and stroke. This enzyme results in the synthesis of thromboxane, which increases blood pressure and causes blood clots.

"The present work is unique because it opens up a new concept as to the cause and subsequent consequences of preeclampsia relating to epigenetics," said corresponding author Scott W. Walsh, Ph.D. , professor in the VCU Department of Obstetrics and Gynecology . "It is the first study to show that epigenetic alterations in the blood vessels of the mother are related to preeclampsia."

According to Walsh, one of the main epigenetic mechanisms is methylation of the DNA, which controls the expression of genes. The increase of this enzyme in the blood vessels is related to reduced DNA methylation and the infiltration of neutrophils into the blood vessels. Neutrophils are white blood cells that normally help fight infection.

In the future, Walsh said some potential treatments for preeclampsia may include inhibition of thromboxane synthase, blockade of thromboxane receptors or dietary supplementation with folate. He said that folate supplementation could increase methylation donors to protect against adverse changes in DNA methylation that affect expression of the thromboxane synthase enzyme.

This study builds on previously published work by the VCU team that appeared in the November 2011 issue of Hypertension and in the January 2011 issue of the American Journal of Pathology and demonstrated a significant role for neutrophils as causative agents of high blood pressure in preeclampsia.


'/>"/>
Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Related medicine news :

1. Physical Changes in Brain Linked to Altered Spirituality
2. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
3. Medicare Advantage Members May Make Changes During Open Enrollment
4. CMS Watch Changes Name to The Real Story Group
5. Changes during menopause increases risk of heart disease and stroke
6. Childhood stress such as abuse or emotional neglect can result in structural brain changes
7. Dmatek Changes its Name to Attenti
8. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
9. YourHCG.com Changes the Way People Lose Weight by Offering an Affordable HCG Diet Plan
10. Small Nutritional Changes are a Key to Health, Weight Loss, says DSM Personalized Nutrition
11. Canadian Cattle Producers Willing to Make Changes to Prevent E. coli O157 Contamination on their Farms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2017)... ... ... Branches, Inc. has been partnering with The Miami Foundation for over 9 ... focused on providing opportunity to low-income families and breaking the cycle of generational poverty. ... to support its , Climb to College & Career initiative which focuses on postsecondary ...
(Date:6/22/2017)... ... ... its pervasiveness, many physicians are unfamiliar with how best to treat of NeuP, partly ... a timely review has been published in the Journal of Pain Research ... preclinical scientists on its diagnosis and choice of treatment. , The review, titled “ ...
(Date:6/20/2017)... , ... June 20, 2017 , ... ... announced today that Claritas Capital, a Nashville-based private equity firm, has invested $3.35 ... expansion plans for some time, and Claritas Capital offers the smart money, speed ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... has published a new eBook titled “ 5 Questions to Ask Before Entering ... Analyst on the Genetic Test Evaluation (GTE) team, the book explores the various ...
(Date:6/20/2017)... ... , ... AMC Health , the leading provider of proven real-time virtual ... Similar to its approach in demonstrating positive outcomes in the healthcare market, AMC Health ... value of eVisits to support virtual studies. , In a study concluded ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... Inc., (Nasdaq: NVAX ) today announced that data ... RSV F protein recombinant nanoparticle vaccine candidate (RSV F Vaccine) ... the journal Vaccine (the data contained ... The Company previously announced top line results from ... F Vaccine with the goal of protecting infants from RSV ...
(Date:6/2/2017)... Mass. , June 2, 2017  NxStage Medical, ... renal care, today announced new findings demonstrating positive biochemical ... ® System One™. The data will be presented ... in Madrid, Spain . ... to Improve Home Dialysis Network in Europe ...
(Date:5/29/2017)... Biotechnology Ltd. (NASDAQ: APOP ; TASE: APOP), a ... of stem cells, today provided a corporate update and ... 31 st , 2017. "We are ... of 2017," said Dr. Shai Yarkoni, Chief Executive Officer. ... the first blood cancer patient in the recently initiated ...
Breaking Medicine Technology: