Navigation Links
Changes in Cerebrospinal Fluid May Signal Early Alzheimer's
Date:1/2/2012

MONDAY, Jan. 2 (HealthDay News) -- Searching for a better screen for early Alzheimer's disease, researchers think they have found a marker of change in the brain that precedes the onset of the disease by five to 10 years.

The indicator of trouble to come, they say, is a shift in the levels of specific components of the cerebrospinal fluid (CSF) in the brain and spinal cord. Among patients already diagnosed with mild cognitive impairment, a drop in such levels appears to be a sign of Alzheimer's years before symptoms develop.

The discovery, published in the January issue of Archives of General Psychiatry, could potentially aid in the use of disease-modifying therapies, which are designed to work best if applied when a patient is still in the early stages of disease.

"These markers can identify individuals at high risk for future [Alzheimer's disease] at least five to 10 years before conversion to dementia," study author Dr. Peder Buchhave, of Lund University and Skane University in Sweden, noted in a journal news release. "Hopefully, new therapies that can retard or even halt progression of the disease will soon be available. Together with an early and accurate diagnosis, such therapies could be initiated before neuronal degeneration is too widespread and patients are already demented."

The study results stem from more than nine years of follow-up to prior research that had involved 137 patients diagnosed with mild cognitive impairment, a mental state that often precedes dementia.

Over the course of the study, nearly 54 percent of the patients went on to develop Alzheimer's, while another 16 percent were ultimately diagnosed with different forms of dementia.

Specifically, among those who developed Alzheimer's, the researchers found that key aspects of their cerebrospinal fluid dropped off in the years before. In addition, other fluid properties actually went up.

The study team said that they believe that about nine out of every 10 patients with mild cognitive impairment who experience such fluid shifts will eventually go on to develop Alzheimer's disease.

Commenting on the study, one expert in the United States said that the new research "provides confirmation of the general concept that CSF can predict the progression of mild memory loss to mild dementia."

Dr. Sam Gandy, associate director of the Mount Sinai Alzheimer's Disease Research Center at Mount Sinai School of Medicine in New York City, added that the results of the European study largely echo those of a trial reported by researchers at the U.S. National Institutes of Health in 2010.

He noted that methods of early detection might prove valuable for research into the treatment of Alzheimer's disease.

"Most new Alzheimer's drugs are aimed at reducing amyloid [protein plaque] accumulation, and the general consensus is that these drugs will only work at early or presymptomatic stages of disease," said Gandy, who is also Mount Sinai Chair in Alzheimer's Disease Research. "The new paper strengthens the likelihood that CSF biomarkers can be useful for identifying that population of subjects with early or presymptomatic disease in order to recruit them into trials."

More information

For more on early signs of Alzheimer's, visit the Alzheimer's Association.

-- Alan Mozes

SOURCES: Sam Gandy, M.D., Ph.D., Mount Sinai Chair in Alzheimer's Disease Research, professor of neurology and psychiatry director, Mount Sinai Center for Cognitive Health, associate director, Mount Sinai Alzheimer's Disease Research Center Mount Sinai School of Medicine and James J. Peters VA Medical Center; Archives of General Psychiatry, news release, Jan. 2, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Physical Changes in Brain Linked to Altered Spirituality
2. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
3. Medicare Advantage Members May Make Changes During Open Enrollment
4. CMS Watch Changes Name to The Real Story Group
5. Changes during menopause increases risk of heart disease and stroke
6. Childhood stress such as abuse or emotional neglect can result in structural brain changes
7. Dmatek Changes its Name to Attenti
8. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
9. YourHCG.com Changes the Way People Lose Weight by Offering an Affordable HCG Diet Plan
10. Small Nutritional Changes are a Key to Health, Weight Loss, says DSM Personalized Nutrition
11. Canadian Cattle Producers Willing to Make Changes to Prevent E. coli O157 Contamination on their Farms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Changes in Cerebrospinal Fluid May Signal Early Alzheimer's 
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology: