Navigation Links
Change in breast density over time provides clues about breast cancer risk
Date:4/20/2010

WASHINGTON A decrease in breast density, or the proportion of fibroglandular tissue depicted on the mammogram image, over a number of years is associated with decreased risk of breast cancer, researchers from the Mayo Clinic campus in Minnesota report at the American Association for Cancer Research (AACR) 101st Annual Meeting 2010.

The researchers found a 28 percent reduced risk of developing breast cancer in women whose breasts decreased in density, as seen from two different mammograms taken an average of six years apart, compared to women whose breast density did not change.

Two measures of breast density may, therefore, provide additional information for assessing breast cancer risk, says the study's lead investigator, Celine Vachon, Ph.D., an associate professor of epidemiology. Dr. Vachon adds, however, that this information is not ready for use in clinical practice to inform breast cancer risk. "Replication of these findings in other studies will be important," she says. "Also, improved and standardized measurements of breast density are needed for the assessment of changes in density."

The current assessment available in most clinical settings is BI-RADS, Breast Imaging-Reporting and Data System, which is relatively unsophisticated when it comes to measuring breast density and was not intended for this purpose, Dr. Vachon says. "There is a lot of ongoing work aimed at improving measures of density, so that situation should change," she adds.

This study was drawn from the Mammography Health Study, which enrolled 19,924 women who were free of breast cancer, had screening mammograms performed at Mayo Clinic between 2003 and 2006 and resided in Minnesota, Iowa and Wisconsin. From this large group, the researchers selected participants who had at least one additional screening mammogram prior to enrollment, and then looked at clinic and tumor registries in the three Midwestern states to determine if any of these women developed breast cancer after enrolling in the study.

Measures of mammographic density were obtained from the two mammograms, an average of six years apart, for the approximately 1,900 women randomly sampled from the cohort, and from all 219 individuals who were diagnosed with breast cancer during follow-up. In the cancer-free group, 38.6 percent of women had a decrease in breast density, 50.4 percent stayed the same, and 11 percent showed an increase in breast density. In women who developed breast cancer, the percentages were 37, 51 and 12, respectively.

Women who developed breast cancer were less likely to experience a decrease in density in a second mammogram, says Dr. Vachon. After adjusting for other potential factors that contribute to breast cancer development, such as age, body mass index, postmenopausal hormones, postmenopausal status, in addition to baseline breast density, the researchers found that women who decreased one BI-RADS category or more over an average of six years were at 28 percent reduced risk of developing breast cancer, compared to women whose density was unchanged.

"We know that breast density can change with time, as evidenced by decreases seen with women going through menopause or using the breast cancer preventive drug tamoxifen and increases seen with postmenopausal hormone therapy use. Our results suggest that decreases in density may translate to decreased breast cancer risk," Dr. Vachon says.


'/>"/>

Contact: Karl Oestreich
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Video Games Before Bed May Not Shortchange Slumber
2. Study finds changes in fetal epigenetics throughout pregnancy
3. Maryland's Preeminent Domestic Violence Agency Announces New Organizational Changes
4. Online Body Transformation Contest Proven to be a Life Changer
5. Calvert Holdings Announces Executive Changes for Calvert Research
6. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
7. Living donor exchange poses new option for liver transplantation
8. Free Anti-Aging Teleseminar Teaches People Key Lifestyle Changes To Maximize Longevity
9. FRCA Asks: What did Representatives Perriello, Kildee and Oberstar Receive in Exchange for Betraying the Pro-Life Cause?
10. Picture a Healthier You: Life...supplemented Photo Contest Asks Americans for a Snapshot of Healthy Changes
11. MEDNET and Hielix Awarded the State of North Dakota Contract for Statewide Health Information Exchange (HIE) Strategic and Operational Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... the only authorized OSHA Training Institute Education Center headquartered in Northern California, has ... workers from extreme heat at their worksites. Employers with workers exposed to ...
(Date:6/27/2016)... Aliso Viejo, California (PRWEB) , ... June 27, 2016 , ... ... that are fully customizable inside of Final Cut Pro X," said Christina Austin - ... with another unique style. Final Cut Pro X users can now reveal ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... One of Australia,s successful biotechnology scientists, Dr ... biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). Noxopharm ... on the ASX. Noxopharm is a clinic-ready company with ... 1 clinical study later this year. ... problems facing cancer patients - the ability of cancers to become ...
(Date:6/26/2016)... 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ... Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) expired ... Time). As previously announced on May 31, ... merger agreement under which Jazz Pharmaceuticals has commenced a ...
(Date:6/26/2016)... -- VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported today ... to build a strong and stable market for trading ... the OTC Markets-pink current trading platform. Explains ... seeing an anomaly in market trading activities that may ... Company, but shareholders and market players as well. I ...
Breaking Medicine Technology: