Navigation Links
Cesareans weaken gut microbiota and increase risk of allergies

Children who came into the world by Caesarean section are more often affected by allergies than those born in the natural way. The reason for this may be that they have a less diverse gut microbiota, according to a study by universities in Sweden and Scotland.

The researchers have followed gut macrobiota development in 24 children up to the age of two in the Swedish provinces of stergtland and Smland, nine delivered through Caesarean and 15 delivered naturally, through vaginal birth. They used a type of molecular biology analysis, which gives a broad overview of the varieties of bacteria present in the intestines.

The results are presented in the scientific journal Gut, with Anders Andersson of the KTH Royal Institute of Technology and Science for Life Laboratory as the senior author. Other researchers in the study come from Linkping University, Karolinska Institutet (KI), rebro University and the University of Glasgow, Scotland.

Those that were delivered by Caesarean section had a less diverse gut microbiota during their first two years of life than those born vaginally. Particularly clear was the low diversity among the group Bacteroidetes that, according to earlier observations of the research groups, are particularly linked to protection against allergies. Thus, these children may run greater risk of developing allergies, but diabetes and irritable bowel syndrome are also more common among children born by Caesarean.

"Sometimes Caesarean sections are necessary. But it is important that both expectant mothers and doctors are aware that such a delivery may affect the child's health," says Maria Jenmalm, professor of Experimental Allergology at Linkping University and one of the authors of the article.

Everything indicates that right up until the moment of birth the child's gut is completely sterile. Colonisation by many different bacteria is believed to be necessary for the immune system to develop and mature over the first years of life. If this does not happen there is a risk that the system can overreact against innocuous antigens in its surroundings, for example foodstuffs. Children affected by such allergies run a six times greater risk of developing asthma in their school years.

With natural birth the child is exposed to bacteria in the mother's birth canal, a good start to the formation of the child's own gut microbiota.

For those who entered the world through an incision in their mother's belly, different measures need to be developed.

"It might not be so good to have six months of only breast feeding. Earlier exposure to ordinary solid food may stimulate a higher diversity of the gut microbiota," Jenmalm says.

A more radical idea is now being tested by researchers in Puerto Rico. In the study a number of pregnant women have their vaginal microbiota screened before their planned Caesarean. After the birth the midwife takes a compress with secretions from the mother's vagina and smears it over the baby's face. The theory is that in this way the important bacteria may be transferred to the child. A similar study in Sweden is being planned.

Besides a greater diversity in their intestinal flora, children delivered vaginally in the Linkping study also had higher blood plasma levels of substances linked to Th1 cells, a kind of "chief cells" in the immune system, which can inhibit allergic immune responses.

The gut microbiota may be regarded as the biggest organ in the body. In the small and large intestines of an adult, there are at least ten times more bacteria than there are cells in the body. The number of species in a human exceeds 100. They use the nutrients in what we eat and in return for the food they provide a range of services. For example, some of them produce antibiotic-like substances which can kill off other unpleasant bacteria.

"One condition for these new insights into this fascinating universe of bacteria is the recent advances in biotechnology. With modern DNA sequencing and computer analysis methods we can determine the species composition in hundreds of samples at the same time, and even get an idea of what characteristics the bacteria have," says Anders Andersson, researcher in metagenomics at the KTH Royal Institute of Technology and Science for Life Laboratory.


Contact: Maria Jenmalm
Linkping University

Related medicine news :

1. Higher risk of maternal complications/preterm deliveries for women undergoing multiple cesareans
2. Temple scientists weaken HIV infection in immune cells using synthetic agents
3. Immune System May Not Weaken With Age: Study
4. Deep Belly Fat Could Weaken Mens Bones, Study Suggests
5. Solving the mystery of how cigarette smoking weakens bones
6. Money Woes Weaken the Institution of Marriage: Study
7. Stopping and starting cancer cell cycle weakens and defeats multiple myeloma
8. Surgical sling reduces risk of weakened bladder control after prolapse surgery, U-M study says
9. Other stomach microbiota modulate resistance to H. pylori-driven ulcers
10. Gut microbiota research: Pinpointing a moving target
11. Gut microbiota plays important role in functional bowel disorders
Post Your Comments:
(Date:6/27/2016)... ... , ... recently awarded their highest five-star rating to Best Buy Eyeglasses, ... the United States and Canada wear eyeglasses. Once considered to be a purely functional ... a fashion statement. Even celebrities use glasses as a way of creating an iconic ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
Breaking Medicine Technology: