Navigation Links
Cesareans weaken gut microbiota and increase risk of allergies
Date:8/8/2013

Children who came into the world by Caesarean section are more often affected by allergies than those born in the natural way. The reason for this may be that they have a less diverse gut microbiota, according to a study by universities in Sweden and Scotland.

The researchers have followed gut macrobiota development in 24 children up to the age of two in the Swedish provinces of stergtland and Smland, nine delivered through Caesarean and 15 delivered naturally, through vaginal birth. They used a type of molecular biology analysis, which gives a broad overview of the varieties of bacteria present in the intestines.

The results are presented in the scientific journal Gut, with Anders Andersson of the KTH Royal Institute of Technology and Science for Life Laboratory as the senior author. Other researchers in the study come from Linkping University, Karolinska Institutet (KI), rebro University and the University of Glasgow, Scotland.

Those that were delivered by Caesarean section had a less diverse gut microbiota during their first two years of life than those born vaginally. Particularly clear was the low diversity among the group Bacteroidetes that, according to earlier observations of the research groups, are particularly linked to protection against allergies. Thus, these children may run greater risk of developing allergies, but diabetes and irritable bowel syndrome are also more common among children born by Caesarean.

"Sometimes Caesarean sections are necessary. But it is important that both expectant mothers and doctors are aware that such a delivery may affect the child's health," says Maria Jenmalm, professor of Experimental Allergology at Linkping University and one of the authors of the article.

Everything indicates that right up until the moment of birth the child's gut is completely sterile. Colonisation by many different bacteria is believed to be necessary for the immune system to develop and mature over the first years of life. If this does not happen there is a risk that the system can overreact against innocuous antigens in its surroundings, for example foodstuffs. Children affected by such allergies run a six times greater risk of developing asthma in their school years.

With natural birth the child is exposed to bacteria in the mother's birth canal, a good start to the formation of the child's own gut microbiota.

For those who entered the world through an incision in their mother's belly, different measures need to be developed.

"It might not be so good to have six months of only breast feeding. Earlier exposure to ordinary solid food may stimulate a higher diversity of the gut microbiota," Jenmalm says.

A more radical idea is now being tested by researchers in Puerto Rico. In the study a number of pregnant women have their vaginal microbiota screened before their planned Caesarean. After the birth the midwife takes a compress with secretions from the mother's vagina and smears it over the baby's face. The theory is that in this way the important bacteria may be transferred to the child. A similar study in Sweden is being planned.

Besides a greater diversity in their intestinal flora, children delivered vaginally in the Linkping study also had higher blood plasma levels of substances linked to Th1 cells, a kind of "chief cells" in the immune system, which can inhibit allergic immune responses.

The gut microbiota may be regarded as the biggest organ in the body. In the small and large intestines of an adult, there are at least ten times more bacteria than there are cells in the body. The number of species in a human exceeds 100. They use the nutrients in what we eat and in return for the food they provide a range of services. For example, some of them produce antibiotic-like substances which can kill off other unpleasant bacteria.

"One condition for these new insights into this fascinating universe of bacteria is the recent advances in biotechnology. With modern DNA sequencing and computer analysis methods we can determine the species composition in hundreds of samples at the same time, and even get an idea of what characteristics the bacteria have," says Anders Andersson, researcher in metagenomics at the KTH Royal Institute of Technology and Science for Life Laboratory.


'/>"/>

Contact: Maria Jenmalm
maria.jenmalm@liu.se
46-010-103-4101
Linkping University
Source:Eurekalert

Related medicine news :

1. Higher risk of maternal complications/preterm deliveries for women undergoing multiple cesareans
2. Temple scientists weaken HIV infection in immune cells using synthetic agents
3. Immune System May Not Weaken With Age: Study
4. Deep Belly Fat Could Weaken Mens Bones, Study Suggests
5. Solving the mystery of how cigarette smoking weakens bones
6. Money Woes Weaken the Institution of Marriage: Study
7. Stopping and starting cancer cell cycle weakens and defeats multiple myeloma
8. Surgical sling reduces risk of weakened bladder control after prolapse surgery, U-M study says
9. Other stomach microbiota modulate resistance to H. pylori-driven ulcers
10. Gut microbiota research: Pinpointing a moving target
11. Gut microbiota plays important role in functional bowel disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 03, 2016 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... in New York City, with long-time partners The Paul Foundation, on November 10, ...
(Date:12/4/2016)... ... 04, 2016 , ... "Pro3rd Displace is a set of ... displacement design elements," said Christina Austin - CEO of Pixel Film Studios. ... of design styles that include both left aligned and right aligned options for ...
(Date:12/2/2016)... ... ... Lori G. Cohen and Sara K. Thompson , shareholders in global ... Institute’s 21st Drug & Medical Device Litigation Conference , taking place in New York ... who chairs the firm’s Pharmaceutical, Medical Device & Health Care Litigation Practice and the ...
(Date:12/2/2016)... ... 02, 2016 , ... Advanced Inc., a leading provider of travel therapy and ... to serve as Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously ... financial and operational leadership experience to Advanced Inc. He began his career in finance ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of pain management programs ... patients must find the one that works for them. When an inventor from Suisun ... that worked and decided to share it with others. , He developed a prototype ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... N.J. , Dec. 3, 2016  Findings ... and safety of CTL019, an investigational chimeric antigen ... (r/r) pediatric and young adult patients with B-cell ... during an oral session at the 58th American ... December 3, 4:00-5:30 p.m.). The global Phase II ...
(Date:12/2/2016)... bioLytical Laboratories, un líder mundial en test rápidos de ... Self Test , a los miembros de la Kenya Pharmaceutical Association. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ... (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la Clinton ...
(Date:12/2/2016)... According to the latest market report ... Automated Endoscope Reprocessors: Single Basin Automated Endoscope Reprocessors Product Type ... and 2024 " the global automated endoscope reprocessors market was valued at US$ ... a CAGR of 7.2% during an eight-year forecast period 2016-2024, ... 2024. ...
Breaking Medicine Technology: