Navigation Links
Cervical cancer screening in less-developed areas should be tailored to local conditions
Date:1/14/2013

The best approach to detecting cervical cancer in HIV-positive women living in research limited countries such as those in Sub-Saharan Africa combines commonly used testing methods tailored to local levels of development and medical infrastructure, according to a study by researchers from and the University of Witwatersrand in South Africa and the University of North Carolina.

The research evaluated the effectiveness of three commonly used screening methods the pap smear, human papillomavirus testing (HPV) and visual inspection of the cervix with acetic acid (VIA) among 1,202 South African women tested over a period between 2009 and 2011. Led by Cynthia Firnhaber, MD, associate professor of medicine at the University of Witwatersrand and Jennifer Smith, PhD, research associate professor at UNC and member of UNC Lineberger Cancer Center, the study findings were published by PLOS ONE on Jan. 11, 2013.

Invasive cervical cancer is the third most common cancer worldwide in women, and HIV-positive women are at an increased risk for acquiring the disease. In areas such as Africa where HIV infection has become endemic, access to health services greatly increases the chance of detection and survival. Cervical cancer, which is completely preventable, is the leading cause of cancer death in women from Sub-Saharan Africa.

In its earliest stages, invasive cervical cancer begins as pre-cancerous lesions on the cervix known as cervical intraepithelial neoplasia (CIN). Graded on a scale from 1 to 3 by severity, the lesions can take years to progress to an invasive cancer, allowing a large window for screening to be effective and benign legions to be removed.

As stand-alone tests for high-grade CIN, HPV testing proved most sensitive with a 92 percent overall sensitivity, followed by pap smears (76 percent) and VIA (65.5 percent with nurse interpretation rising to 76 percent with physician review). However the specificity of HPV was reduced compared to Pap smears and VIA.

As each of the tests were viable for detecting cervical lesions, the study's authors determined that the decision on which to use must depend on factors such as cost, patient population, availability of skilled medical technicians and laboratory capacity. Using these factors, nations can evaluate which approach will work better for their particular setting, with some benefiting from a mixed approach in different geographical regions within a single country.

"No screening system is perfect and of course we want the best system but the definition of the best and most effective system may vary by the capacity and resources of a location. At present many women are not being screened at all in resource limited countries. We need to be flexible in our approaches to screening so we can reduce the rates of a completely preventable cancer in these countries," said Dr. Firnhaber.


'/>"/>

Contact: William Davis
william_davis@med.unc.edu
919-966-5906 x254
University of North Carolina Health Care
Source:Eurekalert

Related medicine news :

1. Students focus on creating a better cervical collar
2. Simple assault and ground level fall do not require cervical spine CT
3. Cervical Cancer Spotted Later in Women Without Health Insurance
4. Lack of insurance linked to advanced stage cervical cancer
5. HPV testing in HIV-positive women may help reduce frequent cervical cancer screening
6. HIV-infected women do not appear to be at increased risk of cervical cancer
7. Women With HIV May Not Have Higher Cervical Cancer Risk: Study
8. Cervical Disease Treatment Not Linked to Premature Birth Risk
9. Cervical cancer and pre-cancer cervical growths require single HPV protein
10. New test may improve cervical cancer detection
11. Study Suggests Vaccine May Help Kids With Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... professionals, announced today its affiliation with Tennessee Counseling Association. This new ... network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , ...
(Date:6/27/2016)... KS (PRWEB) , ... June 27, 2016 , ... TopConsumerReviews.com ... retailers of Eyeglasses . , Millions of individuals in the United States and ... have become a way to both correct vision and make a fashion statement. Even ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
Breaking Medicine Technology: