Navigation Links
Cervical cancer screening in less-developed areas should be tailored to local conditions
Date:1/14/2013

The best approach to detecting cervical cancer in HIV-positive women living in research limited countries such as those in Sub-Saharan Africa combines commonly used testing methods tailored to local levels of development and medical infrastructure, according to a study by researchers from and the University of Witwatersrand in South Africa and the University of North Carolina.

The research evaluated the effectiveness of three commonly used screening methods the pap smear, human papillomavirus testing (HPV) and visual inspection of the cervix with acetic acid (VIA) among 1,202 South African women tested over a period between 2009 and 2011. Led by Cynthia Firnhaber, MD, associate professor of medicine at the University of Witwatersrand and Jennifer Smith, PhD, research associate professor at UNC and member of UNC Lineberger Cancer Center, the study findings were published by PLOS ONE on Jan. 11, 2013.

Invasive cervical cancer is the third most common cancer worldwide in women, and HIV-positive women are at an increased risk for acquiring the disease. In areas such as Africa where HIV infection has become endemic, access to health services greatly increases the chance of detection and survival. Cervical cancer, which is completely preventable, is the leading cause of cancer death in women from Sub-Saharan Africa.

In its earliest stages, invasive cervical cancer begins as pre-cancerous lesions on the cervix known as cervical intraepithelial neoplasia (CIN). Graded on a scale from 1 to 3 by severity, the lesions can take years to progress to an invasive cancer, allowing a large window for screening to be effective and benign legions to be removed.

As stand-alone tests for high-grade CIN, HPV testing proved most sensitive with a 92 percent overall sensitivity, followed by pap smears (76 percent) and VIA (65.5 percent with nurse interpretation rising to 76 percent with physician review). However the specificity of HPV was reduced compared to Pap smears and VIA.

As each of the tests were viable for detecting cervical lesions, the study's authors determined that the decision on which to use must depend on factors such as cost, patient population, availability of skilled medical technicians and laboratory capacity. Using these factors, nations can evaluate which approach will work better for their particular setting, with some benefiting from a mixed approach in different geographical regions within a single country.

"No screening system is perfect and of course we want the best system but the definition of the best and most effective system may vary by the capacity and resources of a location. At present many women are not being screened at all in resource limited countries. We need to be flexible in our approaches to screening so we can reduce the rates of a completely preventable cancer in these countries," said Dr. Firnhaber.


'/>"/>

Contact: William Davis
william_davis@med.unc.edu
919-966-5906 x254
University of North Carolina Health Care
Source:Eurekalert

Related medicine news :

1. Students focus on creating a better cervical collar
2. Simple assault and ground level fall do not require cervical spine CT
3. Cervical Cancer Spotted Later in Women Without Health Insurance
4. Lack of insurance linked to advanced stage cervical cancer
5. HPV testing in HIV-positive women may help reduce frequent cervical cancer screening
6. HIV-infected women do not appear to be at increased risk of cervical cancer
7. Women With HIV May Not Have Higher Cervical Cancer Risk: Study
8. Cervical Disease Treatment Not Linked to Premature Birth Risk
9. Cervical cancer and pre-cancer cervical growths require single HPV protein
10. New test may improve cervical cancer detection
11. Study Suggests Vaccine May Help Kids With Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... , ... January 23, 2017 , ... ... educational institution’s inaugural K-20 Education Summit to be held March 23-25, 2017 in ... by Jan. 25, 2017. , The keynote speakers include Dr. Michelle R. Weise, ...
(Date:1/23/2017)... Dc (PRWEB) , ... January 23, 2017 , ... ... American University is taught by healthcare management and evaluation leaders with decades of ... fee-for-service to pay-for-value in the United States healthcare system, there is a renewed ...
(Date:1/23/2017)... ... January 23, 2017 , ... METTLER TOLEDO has ... Chemistry by Applying Simple PAT Tools . , Crystallization is a ... the desired product. Chemists now spend more time developing better intermediate and ...
(Date:1/23/2017)... ... ... Old School Labs™, makers of the wildly popular all-natural sports supplements based ... its growing team of brand ambassadors. The Olympia top finisher and former Big 12 ... year was able to turn professional, participating in the 2013 NPC USA Championships in ...
(Date:1/23/2017)... ... 2017 , ... “Crossing the Bar”: a moving and eloquent drama depicting ... the Bar” is the creation of published author, Charlotte Hotte, a North Carolina native, ... the inspiration of the book to her sister, Denise, wishes to acknowledge her savior, ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , Jan 23, 2017 Research and Markets ... Analysis & Trends - Product - Forecast to 2025" report to ... Report Highlights: ... and future market trends to identify the investment opportunities ... Key market trends across the business segments, Regions and ...
(Date:1/23/2017)... -- Stock-Callers.com today presents the following Generic Drugs ... ), Sophiris Bio Inc. (NASDAQ: SPHS ), Momenta ... Inc. (NASDAQ: AGRX ). These companies are part ... trade on Friday, January 20 th , 2017, with the ... health care companies in the S&P 500 also were sinking ...
(Date:1/23/2017)... , 23. Januar 2017  ResMed (NYSE: ... ) und 3B Medical ( Winter Haven, Florida ... eine Vereinbarung über die Beilegung aller globalen Rechtsstreitigkeiten zwischen ... der Verkauf ihrer bestehenden Produkte im Tausch gegen ... Zahlung an 3B leisten, um das in ...
Breaking Medicine Technology: