Navigation Links
Cervical cancer and pre-cancer cervical growths require single HPV protein
Date:9/17/2012

MADISON Human papillomavirus (HPV) has long been implicated in cervical cancer, but details of how it happens have remained a mystery. Now researchers at the University of Wisconsin-Madison have found that a single HPV protein is required for cervical cancer and even pre-cancer growths in the cervix to survive.

In anticipation of a clinical trial in humans, the scientists and their collaborators are moving quickly to test if a gene-silencing technique could cripple the protein and eliminate cervical cancer and pre-cancerous growths in specially-bred mice.

The study, appearing online in Cancer Research, is the first to show that the protein works in living animals and in pre-cancerous growths as well as full-blown cervical cancer.

Cervical cancer is relatively rare in the United States, thanks to the widespread use of Pap smears as a screening tool. But pre-cancer lesions in the cervix, called cervical inter-epithelial neoplasias, or CINs, are common.

Low-grade CINs are typically left alone because most will shrink and pose no problem. But women with high-grade CINs have a 10 percent chance of getting cervical cancer, says Dr. Paul Lambert, senior author on the paper. In addition, surgical treatment of high-grade CINs carries a risk of excessive bleeding and even infertility.

Scientists know that two HPV cancer-causing proteins, or oncoproteinsE6 and E7are always expressed in cervical cancer. Lambert and his team at UW's McArdle Laboratory of Cancer Research conducted experiments in cultured cell lines that suggested that the oncoproteins caused cervical cancer as well as anal and head and neck cancers. The researchers also learned that E7 had a much greater ability than E6 to cause cancer.

Other studies in different types of cancers suggested that when oncoproteins were involved, they needed to work together--blocking the expression of both often led to a more effective reduction of tumors than bloc
'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Students focus on creating a better cervical collar
2. Simple assault and ground level fall do not require cervical spine CT
3. Cervical Cancer Spotted Later in Women Without Health Insurance
4. Lack of insurance linked to advanced stage cervical cancer
5. HPV testing in HIV-positive women may help reduce frequent cervical cancer screening
6. HIV-infected women do not appear to be at increased risk of cervical cancer
7. Women With HIV May Not Have Higher Cervical Cancer Risk: Study
8. Cervical Disease Treatment Not Linked to Premature Birth Risk
9. Study Suggests Vaccine May Help Kids With Brain Cancer
10. New Stool Test Might Aid in Early Detection of Colon Cancer
11. Study reveals how cancer drug causes diabetic-like state
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... In its comprehensive analysis of medical claims, ... division have recently identified out-of-network and medical necessity reviews ... achieved on behalf of employer-clients. , The third ... to Argus each year, with a total of $6.4 ... Doney, Cypress president and CEO, these in-depth medical claim ...
(Date:12/17/2014)... Alan Mozes HealthDay Reporter ... world of infectious diseases, one worrisome phenomenon is when an ... The process -- known as zoonosis -- is not uncommon ... signs that an animal-borne disease might make inroads into the ... a development -- and the culprits in this case were ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. ... to improve overall health, but a growing body of evidence ... new review finds. In fact, the benefits were similar ... lead researcher Paula Chu, a doctoral candidate at Harvard University,s ... clinical trials, found that people randomly assigned to take yoga ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), ... a new study providing evidence on the impact of ... children. , Sufficient enough evidence already exists showing a ... juice drinks, with the onset of tooth decay. One ... listed as 100% fruit juice, meaning it is completely ...
(Date:12/15/2014)... Steven Reinberg HealthDay Reporter ... study should reassure the millions of American women who have ... cancer. "There is no association between migraine and breast ... of medicine at Harvard Medical School. "There is no positive ... is no protective effect either." About 18 percent of ...
Breaking Medicine News(10 mins):Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 3Health News:Yoga May Cut Heart Disease Risk Factors 2Health News:Yoga May Cut Heart Disease Risk Factors 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2
... fundamental change in the U.S. health care system , ... Washington, D.C. ... Challenge (DTCC) released today by the American Pharmacists Association (APhA) ... people with diabetes manage their disease and reduce health care costs., , ...
... evolving approach to treatment of co-morbiditiesWOONSOCKET, R.I., April 6 ... CVS ) published today in the April 2009 issue ... found that over a two-and-a-half year period ending in ... blood pressure, high cholesterol and diabetes among children increased ...
... high-fiber, low-sugar regimen reduced risk factors , , MONDAY, ... reducing sugar consumption can help reduce type 2 diabetes ... , "Latino children are more insulin-resistant and thus more ... counterparts. To date, only a few studies have examined ...
... getting same screenings as healthy folks, , , MONDAY, April 6 ... undergo a colonoscopy only if they expect to live ... seriously ill elderly men in the United States are being ... The finding specifically reflects the experiences of men seeking care ...
... Study finds a ,pathway of persistence, throughout life , , MONDAY, ... problems may be at increased risk for suicide when they,re ... included 5,302 people who were born in 1981 and followed ... (24 males, 16 females). Of those, 13 males and two ...
... play a part , , MONDAY, April 6 (HealthDay News) -- Small ... -- in other words, those who have more difficulty delaying gratification ... , The same seems true of young children who ... unclear whether these findings, from two studies published in the April ...
Cached Medicine News:Health News:Diabetes Ten City Challenge Reduces Health Care Costs and Improves Patient Health 2Health News:Diabetes Ten City Challenge Reduces Health Care Costs and Improves Patient Health 3Health News:Diabetes Ten City Challenge Reduces Health Care Costs and Improves Patient Health 4Health News:Diabetes Ten City Challenge Reduces Health Care Costs and Improves Patient Health 5Health News:CVS Caremark Study Documents Changes in Prescription Drug Use to Treat High Blood Pressure, High Cholesterol and Diabetes in Children and Adolescents 2Health News:CVS Caremark Study Documents Changes in Prescription Drug Use to Treat High Blood Pressure, High Cholesterol and Diabetes in Children and Adolescents 3Health News:Dietary Changes Shield Latino Teens From Diabetes 2Health News:Colon Screenings Don't Follow Guidelines, Study Suggests 2Health News:Colon Screenings Don't Follow Guidelines, Study Suggests 3Health News:Early Psychiatric Issues May Predict Suicide in Boys 2Health News:Kids Who Lack Self-Control May Be Prone to Weight Gain 2Health News:Kids Who Lack Self-Control May Be Prone to Weight Gain 3
(Date:12/15/2014)... , Dec. 15, 2014  Stephen Squires, CEO and ... Quantum Materials Corp (OTCQB:QTMM), will be speaking at ... Materials (RCQM) on December 16th, 2014. The RCQM launch ... nanomaterials in attracting top faculty and students and by ... on research. "We have a long ...
(Date:12/15/2014)... and BOSTON , December 15, 2014 ... structure-guided drug discovery and development company, is pleased to ... the United States relating to its ... in the US significantly strengthens the global patent estate ... markets. The suite of patents recently granted ...
(Date:12/13/2014)... , December 12, 2014 ... announced the addition of the  "Global Catheters ... Share, Global Trends, Company Profiles, Analysis, Segmentation ... to their offering.       (Logo: ... made up of medical grade material such ...
Breaking Medicine Technology:Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 3
The lower body blanket is designed to be used primarily during surgery on the upper half of the body....
The torso blanket is designed to affix to the lower abdominal area and cover the upper half of the body....
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
... wide variety of financing options including direct ... a direct lender to dentists and physicians ... proven invaluable to our clients. Our customers ... for financial services because we understand their ...
Medicine Products: