Navigation Links
Cervical cancer and pre-cancer cervical growths require single HPV protein
Date:9/17/2012

MADISON Human papillomavirus (HPV) has long been implicated in cervical cancer, but details of how it happens have remained a mystery. Now researchers at the University of Wisconsin-Madison have found that a single HPV protein is required for cervical cancer and even pre-cancer growths in the cervix to survive.

In anticipation of a clinical trial in humans, the scientists and their collaborators are moving quickly to test if a gene-silencing technique could cripple the protein and eliminate cervical cancer and pre-cancerous growths in specially-bred mice.

The study, appearing online in Cancer Research, is the first to show that the protein works in living animals and in pre-cancerous growths as well as full-blown cervical cancer.

Cervical cancer is relatively rare in the United States, thanks to the widespread use of Pap smears as a screening tool. But pre-cancer lesions in the cervix, called cervical inter-epithelial neoplasias, or CINs, are common.

Low-grade CINs are typically left alone because most will shrink and pose no problem. But women with high-grade CINs have a 10 percent chance of getting cervical cancer, says Dr. Paul Lambert, senior author on the paper. In addition, surgical treatment of high-grade CINs carries a risk of excessive bleeding and even infertility.

Scientists know that two HPV cancer-causing proteins, or oncoproteinsE6 and E7are always expressed in cervical cancer. Lambert and his team at UW's McArdle Laboratory of Cancer Research conducted experiments in cultured cell lines that suggested that the oncoproteins caused cervical cancer as well as anal and head and neck cancers. The researchers also learned that E7 had a much greater ability than E6 to cause cancer.

Other studies in different types of cancers suggested that when oncoproteins were involved, they needed to work together--blocking the expression of both often led to a more effective reduction of tumors than blocking either one alone.

But Lambert, a member of the UW Carbone Cancer Center, was intrigued with E7's power.

"In thinking of treatments, we wondered in this case if we could target just one oncoprotein, the most potent one, rather than two, which could be much more complicated," he says.

Dr. Sean Jabbar and Soyeong Park in the Lambert laboratory created and bred mice in which they could control the expression of both E7 and E6. They found that when he turned off E7 but left E6 on, the cervical cancers and CINs melted away.

"This told us that E7 should be an excellent therapeutic target for HPV-associated cancers, including pre-cancerous CINs," Lambert says.

If the gene-silencing experiments that are expected to take place soon prove effective, there's a good chance that the blocking approach could be used to control the disease without surgery.

Women in developing countries might benefit greatly, Lambert adds.

"Cervical cancer is prevalent around the world in places where screening does not exist and surgery is not available," he says.
'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

Related medicine news :

1. Students focus on creating a better cervical collar
2. Simple assault and ground level fall do not require cervical spine CT
3. Cervical Cancer Spotted Later in Women Without Health Insurance
4. Lack of insurance linked to advanced stage cervical cancer
5. HPV testing in HIV-positive women may help reduce frequent cervical cancer screening
6. HIV-infected women do not appear to be at increased risk of cervical cancer
7. Women With HIV May Not Have Higher Cervical Cancer Risk: Study
8. Cervical Disease Treatment Not Linked to Premature Birth Risk
9. Study Suggests Vaccine May Help Kids With Brain Cancer
10. New Stool Test Might Aid in Early Detection of Colon Cancer
11. Study reveals how cancer drug causes diabetic-like state
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... 24, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5 ... or PMS . , Most women of child-bearing age will experience the symptoms ... headaches, fatigue, and other discomfort. For some women, the effects are severe ...
(Date:1/24/2017)... ... 2017 , ... “Choosing Wisdom-Solomon’s Proverbs Reclaimed”: an inspiring ... prostitution, adultery, anger, and common sense. , “Choosing Wisdom-Solomon’s Proverbs Reclaimed” is ... Coats. In September of 1983, they flew to Haiti to focus on missions ...
(Date:1/24/2017)... ... 24, 2017 , ... “Spiritual Vitamins: A Spiritual Energy Booster”: ... “Spiritual Vitamins: A Spiritual Energy Booster” is the creation of published author, Mathai ... new book engages the mind and spirit in a quest for fulfillment and ...
(Date:1/24/2017)... ... January 24, 2017 , ... “The Octagon of Spiritual ... Octagon of Spiritual Balances” is the creation of published author, Pastor Bernard J. Weathers, ... Weathers holds a bachelor degree in religious education and a master degree in theology. ...
(Date:1/24/2017)... ... January 24, 2017 , ... Attention women who want ... suggests that autologous fat grafting—taking one’s own fat and putting it in other ... , Cosmetic Surgeon and Medical Director of MilfordMD Cosmetic Dermatology Surgery & ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... Jan. 23, 2017 INTRODUCTION Injectable drug ... conventional syringes with vials to prefilled syringes, auto-injectors, ... devices have become preferred devices for parenteral administration ... has been rising strongly over the past several ... now adopting this format for delivering drugs. The ...
(Date:1/24/2017)... , January 23, 2017 ... for life sciences, announces agClinical 3.3, the latest version ... further enables life science organizations to confidently and efficiently ... and better manage the electronic trial master file so ... ...
(Date:1/23/2017)... NEW YORK , Jan. 23, 2017 ... Development Partners and Driving the Stability Testing Outsourcing Market ... testing market addresses market sizing, emerging trends, and technologies, ... the market. The base year is 2015 and forecasts ... market is expected to grow at a CAGR of ...
Breaking Medicine Technology: