Navigation Links
Cervical Cancer Vaccine Well Tolerated
Date:12/4/2008

Reactions such as hives called 'idiosyncratic,' study finds

THURSDAY, Dec. 4 (HealthDay News) -- Reactions to the vaccine designed to protect against cervical cancer are rare, and young women can tolerate subsequent doses.

That's the assessment of Australian researchers who analyzed data after more than 380,000 doses of the Gardasil vaccine were given to girls in secondary schools beginning in April 2007.

Gardasil protects against four types of human papillomavirus (HPV) that increase the risk of cervical cancer. Some ingredients of the vaccine, such as aluminum salts and yeasts, have previously been associated with hypersensitivity reactions.

The Australian researchers identified 35 schoolgirls with suspected hypersensitivity reactions, including hives, generalized rash, swelling of subcutaneous tissues (angioedema), and severe allergic reaction (anaphylaxis).

Twenty-five of the girls agreed to be referred to pediatric allergy centers for further evaluation. This included a detailed account of their reactions, such as previous doses of the vaccine, time and severity of reaction, and previous clinical history. Skin tests of HPV vaccines were conducted, and vaccine challenges were administered intramuscularly. The girls were followed-up by telephone one week after the subsequent dose, and any adverse events were noted, the researchers said.

Nineteen girls had skin testing of the Gardasil vaccine, and all were negative. Seventeen of 18 girls later "challenged" with the vaccine tolerated further doses. One girl reported a limited case of hives four hours after receiving the vaccine. Only three of the 25 evaluated girls had probable hypersensitivity to the vaccine, and the researchers concluded that true hypersensitivity is rare.

They noted that suspected hypersensitivity reactions such as hives are often "idiosyncratic" and don't increase the risk of adverse reactions in subsequent vaccinations. Girls with suspected hypersensitivity to the vaccine should be evaluated before receiving further doses, said the researchers, who called for more research into the mechanisms of hypersensitivity to the vaccine.

The study was published online Dec. 3 in the BMJ.

More information

The U.S. National Cancer Institute has more about HPV vaccines.



-- Robert Preidt



SOURCE: British Medical Journal, news release, Dec. 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cervical cancer screening: Too many are left unprotected
2. Couples more likely to divorce if spouse develops cervical or testicular cancer
3. Gene-Based Screen Spots Cervical Cancer Earlier
4. Transcutaneous cervical esophageal ultrasound can not substitute for 24-h pH monitoring or manometry
5. Advaxis, Inc. phase I/II results of lovaxin C in cervical cancer study released
6. Study: HPV test beats Pap in detecting cervical cancer
7. NEJM Report Finds HPV Test More Effective Than Pap in Determining Cervical Cancer Risk
8. Pa. Funding for Cervical Cancer Prevention Services Ends
9. Precancerous Lesions Raise Cervical Cancer Risk
10. American Medical Womens Association Supports New Bill That Requires Medicare Coverage of HPV Testing as Part of Cervical Cancer Screening
11. Study Finds New Version of QIAGENs HPV Test for Developing Countries Could Reduce Risk of Cervical Cancer by More than Half When Combined With Appropriate Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... VEGAS, NEV. (PRWEB) , ... August 22, 2017 ... ... American Academy of Anti-Aging Medicine recently spoke at a popular international aesthetics conference ... therapy has had on restoring his patients’ health and his growing practice. , ...
(Date:8/22/2017)... ... August 22, 2017 , ... Five Star Glass is new to the Texas market, ... replacement of auto glass for most makes and models, in Grand Prairie, TX, located in ... , They have been a family owned business for the past 40 years with 32 ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is a unique ... Of Light” is the creation of published author, J.M. Shepherd, a writer, teacher, traveler, ... to life’s perplexing mysteries. , Shepherd shares, “Love is one of the least understood ...
(Date:8/21/2017)... ... 22, 2017 , ... PracticeMatch, a company that provides online resources , ... and advanced practitioners like nurse practitioners and physician assistants , will ... of this year. The online career fairs will allow job seekers to connect with ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... ... today announced that it has become the Official Technology Partner of North Country ... AES (Advanced Event Systems) volleyball software, along with providing sport management software ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... June 30, 2017, and updated its financial outlook for ... For the fiscal third quarter, Hill-Rom reported earnings of ... share in the prior-year period. These results reflect after-tax ... share primarily related to the non-cash write-down of assets ...
(Date:7/27/2017)...  West Pharmaceutical Services, Inc. (NYSE: WST ... 2017 and updated financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, ... Net sales at constant currency (organic) grew by 3.9%. ... compared to $0.60 in the prior-year quarter. Second-quarter 2017 ...
(Date:7/26/2017)... , July 26, 2017 Sancilio Pharmaceuticals Company, ... our clinical trial evaluating Altemia TM , an oral ... and Sickle Cell Disease (SCD). The SCOT Trial, is ... efficacy and safety of Altemia TM in pediatric ... under US IND 125274. ...
Breaking Medicine Technology: