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Certain vitamin supplements may increase lung cancer risk, especially in smokers
Date:2/29/2008

Vitamin supplements do not protect against lung cancer, according to a study of more than 77,000 vitamin users. In fact, some supplements may even increase the risk of developing it.

Our study of supplemental multivitamins, vitamin C, vitamin E and folate did not show any evidence for a decreased risk of lung cancer, wrote the studys author, Christopher G. Slatore, M.D., of the University of Washington, in Seattle. Indeed, increasing intake of supplemental vitamin E was associated with a slightly increased risk of lung cancer.

The findings were published in the first issue for March of the American Thoracic Societys American Journal of Respiratory and Critical Care Medicine.

Dr. Slatore and colleagues selected a prospective cohort of 77,126 men and women between 50 and 76 years of age in the Washington state VITAL (VITamins And Lifestyle) study, and determined their rate of developing lung cancer over four years with respect to their current and past vitamin usage, smoking, and other demographic and medical characteristics.

Of the original cohort, 521 developed lung cancer, the expected rate for a low-risk cohort such as VITAL. But among those who developed lung cancer, in addition to the unsurprising associations with smoking history, family history, and age, there was a slight but significant association between use of supplemental vitamin E and lung cancer.

In contrast to the often assumed benefits or at least lack of harm, supplemental vitamin E was associated with a small increased risk of lung cancer, said Dr. Slatore.

When modeled continuously, the increased risk was equivalent to a seven percent rise for every 100 mg/day. This risk translates into a 28 percent increased risk of lung cancer at a dose of 400 mg/day for ten years, wrote Dr. Slatore. The increased risk was most prominent in current smokers.

The idea that vitamin supplements are healthy, or at the very least, do no harm, comes fr
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Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

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