Navigation Links
Certain types of graft-versus-host disease may increase risk of death, Moffitt researcher says
Date:6/17/2013

Joseph Pidala, M.D., M.S., assistant member of the Blood and Bone Marrow Transplant and Immunology programs at Moffitt Cancer Center, and colleagues from the Chronic Graft-Versus-Host Disease Consortium have determined that certain gastrointestinal and liver-related types of chronic graft-versus-host disease (GVHD) are associated with worsened quality of life and death.

Their study appeared in the May issue of Biology of Blood and Marrow Transplantation, the official journal of the American Society for Blood and Marrow Transplantation.

GVHD is a complication that can occur when a transplant patient receives stem cells or bone marrow from a donor. The transplanted cells regard the recipient's body as foreign and attack, causing symptoms ranging from nausea and skin rashes to fatigue and pain. Patients with GVHD are prescribed drugs to suppress their immune system to counteract the disease.

The researchers studied data from 567 patients to determine if the characteristics and symptoms of chronic GVHD were associated with major clinical outcomes, such as quality of life and death. They looked specifically at the site of gastrointestinal tract involvement and liver abnormalities.

"We found important differences in outcomes in relation to gastrointestinal and liver involvement," Pidala said. "Those with elevated bilirubin (a substance in bile) levels, higher gastrointestinal scores, or lower gastrointestinal involvement had an increased risk of death under current treatment approaches."

The authors concluded that their findings will help physicians better define a patient's risk of complications and death after chronic GVHD diagnosis and treatment.


'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
3. Codeine After Surgery Could Endanger Certain Kids: Study
4. Decision guide reduced uncertainty over breast cancer prevention, study finds
5. Certain Genetic Regions May Be Tied to Osteoporosis
6. Hot Flashes More Likely for Certain Smokers, Study Says
7. Early Study Hints at Link Between Certain Sunscreens, Endometriosis
8. Cabazitaxel can offer an advantage in certain patients
9. Antioxidant shows promise as treatment for certain features of autism, Stanford study finds
10. Gout Flare-ups Rise Sharply With Certain Foods: Study
11. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... CA (PRWEB) , ... September 22, 2017 , ... ... groceries, wearable, and more products at customers’ doorstep. According to Smart Mart, customers ... Mart has stated to offer wearable, and customers can find clothing at discounted ...
(Date:9/22/2017)... ... September 22, 2017 , ... Global Lyme Alliance ... research, education and awareness, today announced the appointment of Timothy J. Sellati, Ph.D. ... Sellati has more than 20 years of research experience with Lyme and other ...
(Date:9/21/2017)... ... September 21, 2017 , ... 38-Year-Old Plastic Surgeon Gill at Aesthetic Surgery Center ... pleased to announce that Plastic Surgeon Kiranjeet Gill has been awarded as one of ... an annual award that was started in 2003 to salute young achievers in Southwest ...
(Date:9/21/2017)... ... September 21, 2017 , ... SABRE is raising awareness about personal safety ... the end of November. , The Chicago, Illinois, based self-defense brand has been waiting ... about the ease of taking their personal safety into their own hands. , The ...
(Date:9/21/2017)... ... September 21, 2017 , ... Promotional Communication:, Keeping Up ... , In the competitive world of drug and device marketing and promotion, drug ... FDA rules. , The FDA has issued two draft guidances that are the ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 6, 2017  Robert G. Szewc, M.D., is recognized ... in recognition of his contributions to the Medical field.  ... Nephrologist at the practice of Kidney and Hypertension Specialists, ... and hypertension solutions. He has worked in this position ... experience, as well as expertise in kidneys, hypertension, chronic ...
(Date:9/6/2017)... Sept. 6, 2017 Eli Lilly and Company ... present new data for galcanezumab and lasmiditan, two investigational ... International Headache Society (IHC) taking place Sept. 7-10 in ... will highlight new, long-term data from an open-label study ... galcanezumab (120 mg and 240 mg) for the prevention ...
(Date:9/5/2017)... 2017  Just 18 months after its February 2016 ... announce the appointment of three new senior people to ... Dominic Jones-Phillips and James Wright bring ... Tammy Wynne joins as ... writers. She has over ten years, experience in global ...
Breaking Medicine Technology: