Navigation Links
Certain pain medications do not appear to be associated with skin cancer risk
Date:2/15/2010

Contrary to previous hypotheses, the use of non-steroidal anti-inflammatory drugs does not appear associated with risk of squamous cell skin cancer, according to a report posted online today that will appear in the April print issue of Archives of Dermatology, one of the JAMA/Archives journals.

Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen and celecoxib reduce pain and inflammation by blocking an enzyme involved in producing inflammatory compounds, according to background information in the article. NSAIDs may also inhibit the development of cancer cells by inducing cells to die and inhibiting the growth of new blood vessels.

Laboratory studies of cells and animals have indicated that NSAIDs protect against squamous cell carcinomas, common types of cancers that appear in the upper layers of the skin. However, while some studies have examined the associations between NSAIDs and other types of cancersincluding colorectal, breast, prostate and lungfew have assessed the association between NSAID use and squamous cell carcinoma risk in human populations.

Maryam M. Asgari, M.D., M.P.H., of Kaiser Permanente Northern California, Oakland, and colleagues studied 415 health plan members who were diagnosed with squamous cell carcinoma in 2004 and 415 control patients who were the same age, [Bleep] and race but had no history of skin cancer. Participants completed a questionnaire about NSAID use in the 10 years prior.

The majority of participants (61 percent) reported regular use of NSAIDs within the previous ten years, including 48 percent who used aspirin, 18 percent who used ibuprofen, 5 percent who used naproxen and 4 percent who used nabumetone.

"Regular use of any NSAID was not associated with a reduction in squamous cell carcinoma risk," the authors write. "Although NSAID users whose exposure was of short duration (one to three years) appeared to be at somewhat increased risk for squamous cell carcinoma, we found no consistent effects of duration of use of any NSAID on squamous cell carcinoma risk." Squamous cell carcinoma risk also did not appear to change regardless of NSAID dose, whether the medications were administered by a pharmacy nor with any individual type of NSAID medication.

"Given the potential toxic effects of NSAIDs, including platelet dysfunction and gastric ulcers, more uniformly efficacious chemopreventive agents with safer adverse effect profiles need to be explored," the authors conclude.


'/>"/>

Contact: Maureen McInaney-Jones
maureen.mcinaney@kp.org
510-891-3173
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Hypertension may predict dementia in older adults with certain cognitive deficits
3. G Marks the Spot: Good Vibrations Proclaims February as National G-Spot Month -- Sex Toy Company Says "It Most Certainly Does Exist!"
4. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
5. Video Games Could Boost Certain Thinking Skills
6. Swine Flu Wanes, But Future Uncertain
7. Certain Childhood Cancers More Likely to Recur
8. Greater certainty in monitoring 3 therapeutic medications is facilitated by new CRMs
9. Certain Reflux Drugs Tied to Higher Post-Angioplasty Death Rate
10. FDA Authorizes Emergency Use of Intravenous Antiviral Peramivir for 2009 H1N1 Influenza for Certain Patients, Settings
11. Increased success a virtual certainty for rugby players
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... A prescription medication bottle, ... the fourth Cradle to Cradle Product Design Challenge , the Cradle to ... series of six circular design challenges scheduled to run through early 2018. The challenges ...
(Date:1/17/2017)... Baltimore, MD (PRWEB) , ... January 17, 2017 , ... ... joined the firm as a Principal in its IT Advisory Services practice . ... in recent months as market demand for strategic IT guidance grows, and the practice ...
(Date:1/17/2017)... ... January 17, 2017 , ... The ... in Tyler, has announced the latest beneficiary of their thriving community involvement program. ... organization dedicated to fulfilling the dreams of terminally ill patients. Donations to this ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... the Montclair State University’s Athletic Training Education program forged a relationship built upon ... Education Program, which is consists of both student members and certified members ...
(Date:1/16/2017)... ... , ... Gym Source, America’s leading retailer of premium residential and commercial fitness ... , “We are elated to be opening this new showroom,” explains Tom Richard, Chief ... clients a seamless and motivating shopping experience.” , Every fitness journey is unique, and ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)...  Edwards Lifesciences Corporation (NYSE: EW ), ... disease and critical care monitoring, plans to announce its ... after the market closes on Wednesday, February 1, 2017, ... ET that day to discuss those results. ... or (201) 689-8037.  For 72 hours following the call, ...
(Date:1/17/2017)... Jan. 17, 2017  OrthoAccel ® Technologies, Inc. ... (JCO) has published "The Effect of Vibration on Molar ... by Dr. S. Jay Bowman , this prospective, ... malocclusions, AcceleDent,s SoftPulse Technology ® speeds up molar ... reducing the number of days to move the upper ...
(Date:1/17/2017)... , Jan. 17, 2017 Following an ... today praised the Food and Drug Administration,s (FDA,s) ... Human Drug Products by Pharmacies and Outsourcing Facilities." ... proposed limitation on pre-packaging -- which would have ... costs to long term care (LTC) pharmacies.  ...
Breaking Medicine Technology: