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Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
Date:2/9/2010

predominantly early stage NSCLC. Lung tumor samples with corresponding microarray (genetic analysis of biological material) and clinical data were used. All patients were divided into subgroups based on age (less than 70 vs. 70 years or older) or sex.

Low- and high-risk patient clusters/groups were identified with the longest and shortest 5-year recurrence-free survival, respectively, within the age and sex NSCLC subgroups. The researchers found that these cohorts of NSCLC demonstrated unique patterns of pathway activation. In patients younger than 70 years, high-risk patients, with the shortest recurrence-free survival, demonstrated increased activation of the Src (a gene) (25 percent vs. 6 percent) and tumor necrosis (death of cells or tissue) factor (76 percent vs. 42 percent) pathways compared with low-risk patients. High-risk patients ages 70 years or older demonstrated increased activation of the wound healing (40 percent vs. 24 percent) and invasiveness (64 percent vs. 20 percent) pathways compared with low-risk patients.

The researchers found a difference in the biology of lung cancer between men and women. "In women, high-risk patients demonstrated increased activation of the invasiveness and STAT3 [a gene] pathways while high-risk men demonstrated increased activation of the STAT3, tumor necrosis factor, EGFR [epidermal growth factor receptor; a protein that plays a role in causing cells to grow and multiply], and wound healing pathways," the authors write.

"We believe our findings represent a novel approach to defining clinically relevant cohorts of NSCLC stratified by age and sex that are enriched for specific pathway activity and that would be more apt for therapeutic intervention when planning clinical trials with drugs that target specific pathway-related abnormalities or tumor biology. With genomic assays now being increasingly practical and clinically applicable, with turnaround times of 5 to 7 days, we believe our fin
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Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
JAMA and Archives Journals
Source:Eurekalert

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