Navigation Links
Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
Date:2/9/2010

An analysis of genetic and clinical data for nearly 800 patients with non-small cell lung cancer has identified differences in genetic characteristics that are associated with age and sex specific patterns of increased or decreased recurrence-free survival, according to a study in the February 10 issue of JAMA.

The five-year overall survival rate for lung cancer is only 15 percent, and it remains the leading cause of cancer-related death in the United States. An estimated 159,000 lung cancer deaths occurred in 2009, and more than 219,000 new cases were diagnosed. Almost half of these new cases are diagnosed in women, with approximately 30 percent to 40 percent of cases diagnosed in patients older than 70 years, with the majority of these cases (greater than 85 percent) nonsmall cell lung cancer (NSCLC), according to background information in the article.

"Despite evidence that clinical and pathologic factors (e.g., age, histology, smoking status, sex) are clinically relevant, little is known regarding the underlying biological differences in lung tumor gene expression among patients with different clinicopathologic characteristics. A deeper understanding of molecular abnormalities at a pathway level [involving gene expression and biochemical reactions that transmit information within and between cells] may help dissect the complex mechanisms of lung cancer oncogenesis [development of tumors], shed light on the biological underpinnings contributing to survival differences in NSCLC that are age- and sex-based, and further help identify specific cohorts of patients that may be more susceptible to novel individualized therapeutic strategies," the authors write.

William Mostertz, M.S., of Duke University, Durham, N.C., and colleagues examined clinically relevant differences in the underlying biology of NSCLC based on patient age and sex. The study consisted of an analysis, performed from July 2008 to June 2009, of 787 patients with
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hypertension may predict dementia in older adults with certain cognitive deficits
2. G Marks the Spot: Good Vibrations Proclaims February as National G-Spot Month -- Sex Toy Company Says "It Most Certainly Does Exist!"
3. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
4. Video Games Could Boost Certain Thinking Skills
5. Swine Flu Wanes, But Future Uncertain
6. Certain Childhood Cancers More Likely to Recur
7. Greater certainty in monitoring 3 therapeutic medications is facilitated by new CRMs
8. Certain Reflux Drugs Tied to Higher Post-Angioplasty Death Rate
9. FDA Authorizes Emergency Use of Intravenous Antiviral Peramivir for 2009 H1N1 Influenza for Certain Patients, Settings
10. Increased success a virtual certainty for rugby players
11. Minimally invasive radical prostatectomy shows advantages, but also certain complications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... 2015 Leveraging the industry-leading technology found ... an experienced team of fertility specialists are committed to ... around the globe. , “We’re honored that Maternity Health ... a global leader in reproductive medicine. The clinic offers ... in the world who play an important role in ...
(Date:5/5/2015)... PA (PRWEB) May 05, 2015 The 2015 ... raised $110,000 to benefit their global research, outreach and patient ... silent auction, and awards ceremony that attracted hundreds of supporters. ... of the discovery of the hepatitis B virus (HBV) by ... Blumberg received the Nobel Prize in Medicine for his discovery ...
(Date:5/5/2015)... Viverae®, a health management and engagement ... multinational developer, manufacturer and marketer of innovative, life-enhancing ... oncology and surgical specialty products, as the recipient ... Award recognizes outstanding achievement in the design and ... client base. , Viverae reviewed the employee wellness ...
(Date:5/5/2015)... Sunny skies and cool temperatures made for ... 400 runners and walkers participated in Global Lyme Alliance’s (GLA) ... , The 5K and 10K runs and 1-and 3-mile ... to raise funds for tick-borne disease research. The “Lyme Walk ... recent merger of Lyme Research Alliance (LRA) and Tick-Borne ...
(Date:5/5/2015)... Skedans Systems a division ... the Skedans Sensor Collaboration Platform at AUVSI's Unmanned ... app developers, provides tooling to deliver real time information ... The Skedans Sensor Collaboration Platform is a single unified ... of Things, Web Real Time Communications (WebRTC), and commercial ...
Breaking Medicine News(10 mins):Health News:Maternity Health IVF Clinic in Greece Demonstrates Industry-Leading Fertility Technology 2Health News:Maternity Health IVF Clinic in Greece Demonstrates Industry-Leading Fertility Technology 3Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 2Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 3Health News:Viverae® Honors C. R. Bard, Inc. with 2015 Vanguard Award 2Health News:1st Annual “Lyme Walk & Run” Event a Huge Success 2Health News:1st Annual “Lyme Walk & Run” Event a Huge Success 3Health News:Skedans Systems Announces Skedans Sensor Collaboration Platform at AUVSI's Unmanned Systems 2015 in Atlanta 2
... High-coverage human papillomavirus (HPV) vaccinations among adolescents and young ... warts, cervical cell abnormalities, and diagnostic and therapeutic procedures, ... 5 in the Journal of the National Cancer ... of cervical, vulvar, and vaginal cancers. This study ...
... laws, online testing and Super Bowl plug , FRIDAY, ... concussions in youth sports are making headway on several fronts: ... will get big play Sunday at Super Bowl XLIV, and ... trainers and doctors determine when it,s safe for an athlete ...
... say , FRIDAY, Feb. 5 (HealthDay News) -- Minimally ... injuries in surgeons, suggests a new survey. , University ... percent of laparoscopic surgeons who took part in the ... "We face a pending epidemic of occupational injuries to ...
... , TROY, Mich. , Feb. 5 ... and web products and services company serving U.S. hospitals and ... to the newly formed position of vice president, Marketing, ... , "I am delighted to have Colleen join the CareTech ...
... Feb. 5 /PRNewswire-FirstCall/ - Haemacure Corporation (TSX:HAE) announces that ... 2010 of the delay within which to make a proposal ... its creditors it filed on January 8, 2010 under ... intended to allow Haemacure to complete a call for tenders for ...
... at the Harvard School of Public Health (HSPH) shows that almost ... and levels of concern about getting sick with the virus continue ... will be another widespread outbreak of the H1N1 virus in the ... the population (43%) does say such an outbreak is "somewhat likely." ...
Cached Medicine News:Health News:News brief: HPV vaccines may reduce a wide range of genital diseases 2Health News:Concussion Awareness for Young Athletes Gets Big Play 2Health News:CareTech Solutions Names Colleen M. Hanley Vice President of Marketing, Communications and Government Affairs 2Health News:CareTech Solutions Names Colleen M. Hanley Vice President of Marketing, Communications and Government Affairs 3Health News:Nearly half of Americans believe H1N1 outbreak is over, poll finds 2Health News:Nearly half of Americans believe H1N1 outbreak is over, poll finds 3Health News:Nearly half of Americans believe H1N1 outbreak is over, poll finds 4Health News:Nearly half of Americans believe H1N1 outbreak is over, poll finds 5Health News:Nearly half of Americans believe H1N1 outbreak is over, poll finds 6
(Date:5/5/2015)... Big Market Research presents a detailed analysis of the Hepatitis ... France , Germany , ... Japan . Current scientific views on the Hepatitis definition, ... volume and sales forecasts by country for HAV NAT, HBV NAT, ... Ag, HBe Ag, and ALT/SGPT tests performed in the following markets: ...
(Date:5/5/2015)... 2015  Image Stream Medical, a leader in OR ... one of the largest group purchasing organizations, serving four ... terms of the three-year agreement, Image Stream,s portfolio of ... made available to MedAssets members beginning on July 1, ... Medical CEO Eddie Mitchell said, ...
(Date:5/5/2015)... 2015 Research and Markets ( ... "Clinical Laboratory,Molecular Diagnostics and Genomic Testing Services ... Asia Pacific Version" report to their offering. ... growing. Clinical laboratory testing is positioned to directly ... A range of dynamic trends are pushing market ...
Breaking Medicine Technology:2015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 22015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 3Image Stream Medical Announces Agreement with MedAssets 2Asia Pacific Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Report 2015-2019 2
... Published in Journal ,Nutrition, WALTHAM, Mass., Sept. ... today in the journal Nutrition that a botanical,supplement ... that are associated with over-expression of inflammation,and risk ... few studies that recruited,study subjects who have different ...
... Sept. 25 Findings from an international,multicenter, randomized, ... in the treatment of moderate to severe,plaque psoriasis ... the 21st meeting,of the World Congress of Dermatology, ... 2007 in Buenos Aires, Argentina. The presentation, ...
Cached Medicine Technology:Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products 2Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products 3Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products 4Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products 5Pivotal Ustekinumab (CNTO 1275) Phase 3 Data to Debut at World Congress of Dermatology Meeting 2
... I system consists of four basic components: sample ... metal clamping plate (see diagram). The sample well ... spots, dots, or slots (see below). All three ... an accessory plate in conjunction with a complete ...
... Bio-Dot SF (slot format) microfiltration units provide ... nucleic acid in solution onto nitrocellulose or ... accommodated by using interchangeable templates to form ... format Bio-Dot SF apparatus. Each is available ...
... and Bio-Dot SF (slot format) microfiltration units ... or nucleic acid in solution onto nitrocellulose ... be accommodated by using interchangeable templates to ... slot format Bio-Dot SF apparatus. Each is ...
... clear, APET plastic tray. Ideal for staining ... trays used for multipurposes. Pour spouts in ... marker or label may be used for ... on rockers or shakers for staining several ...
Medicine Products: