Navigation Links
Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
Date:2/9/2010

An analysis of genetic and clinical data for nearly 800 patients with non-small cell lung cancer has identified differences in genetic characteristics that are associated with age and sex specific patterns of increased or decreased recurrence-free survival, according to a study in the February 10 issue of JAMA.

The five-year overall survival rate for lung cancer is only 15 percent, and it remains the leading cause of cancer-related death in the United States. An estimated 159,000 lung cancer deaths occurred in 2009, and more than 219,000 new cases were diagnosed. Almost half of these new cases are diagnosed in women, with approximately 30 percent to 40 percent of cases diagnosed in patients older than 70 years, with the majority of these cases (greater than 85 percent) nonsmall cell lung cancer (NSCLC), according to background information in the article.

"Despite evidence that clinical and pathologic factors (e.g., age, histology, smoking status, sex) are clinically relevant, little is known regarding the underlying biological differences in lung tumor gene expression among patients with different clinicopathologic characteristics. A deeper understanding of molecular abnormalities at a pathway level [involving gene expression and biochemical reactions that transmit information within and between cells] may help dissect the complex mechanisms of lung cancer oncogenesis [development of tumors], shed light on the biological underpinnings contributing to survival differences in NSCLC that are age- and sex-based, and further help identify specific cohorts of patients that may be more susceptible to novel individualized therapeutic strategies," the authors write.

William Mostertz, M.S., of Duke University, Durham, N.C., and colleagues examined clinically relevant differences in the underlying biology of NSCLC based on patient age and sex. The study consisted of an analysis, performed from July 2008 to June 2009, of 787 patients with predominantly early stage NSCLC. Lung tumor samples with corresponding microarray (genetic analysis of biological material) and clinical data were used. All patients were divided into subgroups based on age (less than 70 vs. 70 years or older) or sex.

Low- and high-risk patient clusters/groups were identified with the longest and shortest 5-year recurrence-free survival, respectively, within the age and sex NSCLC subgroups. The researchers found that these cohorts of NSCLC demonstrated unique patterns of pathway activation. In patients younger than 70 years, high-risk patients, with the shortest recurrence-free survival, demonstrated increased activation of the Src (a gene) (25 percent vs. 6 percent) and tumor necrosis (death of cells or tissue) factor (76 percent vs. 42 percent) pathways compared with low-risk patients. High-risk patients ages 70 years or older demonstrated increased activation of the wound healing (40 percent vs. 24 percent) and invasiveness (64 percent vs. 20 percent) pathways compared with low-risk patients.

The researchers found a difference in the biology of lung cancer between men and women. "In women, high-risk patients demonstrated increased activation of the invasiveness and STAT3 [a gene] pathways while high-risk men demonstrated increased activation of the STAT3, tumor necrosis factor, EGFR [epidermal growth factor receptor; a protein that plays a role in causing cells to grow and multiply], and wound healing pathways," the authors write.

"We believe our findings represent a novel approach to defining clinically relevant cohorts of NSCLC stratified by age and sex that are enriched for specific pathway activity and that would be more apt for therapeutic intervention when planning clinical trials with drugs that target specific pathway-related abnormalities or tumor biology. With genomic assays now being increasingly practical and clinically applicable, with turnaround times of 5 to 7 days, we believe our findings, while hypothesis generating and needing further validation, represent a step forward in defining pathway-driven cohorts of NSCLC that likely explain the age- and sex-specific differences seen in NSCLC," the authors conclude.


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Hypertension may predict dementia in older adults with certain cognitive deficits
2. G Marks the Spot: Good Vibrations Proclaims February as National G-Spot Month -- Sex Toy Company Says "It Most Certainly Does Exist!"
3. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
4. Video Games Could Boost Certain Thinking Skills
5. Swine Flu Wanes, But Future Uncertain
6. Certain Childhood Cancers More Likely to Recur
7. Greater certainty in monitoring 3 therapeutic medications is facilitated by new CRMs
8. Certain Reflux Drugs Tied to Higher Post-Angioplasty Death Rate
9. FDA Authorizes Emergency Use of Intravenous Antiviral Peramivir for 2009 H1N1 Influenza for Certain Patients, Settings
10. Increased success a virtual certainty for rugby players
11. Minimally invasive radical prostatectomy shows advantages, but also certain complications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening ... industry leaders in advanced audiology and hearing aid technology, ... ™, the world,s first internet connected hearing aid that ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... ,world firsts,: , TwinLink™ - the first ...
(Date:6/23/2016)... , June 23, 2016 ... "Surgical Procedure Volumes: Global Analysis (United States, China, ... Canada)" report to their offering. ... essential tool for healthcare business planners, provides surgical procedure ... at surgery trends with an in-depth analysis of growth ...
Breaking Medicine Technology: