Navigation Links
Certain cancer therapies' success depends on presence of immune cell, Stanford study shows in mice
Date:10/27/2010

ll of us had assumed that most of the effects we saw on the tumor were relatively independent of the microenvironment of the host."

In contrast, Felsher and his colleagues found that disabling an oncogene called Myc in mice with Myc-dependent leukemias caused complete regression of tumors only in mice with intact immune systems. Tumors in mice with completely or partially compromised immune systems shrank more slowly and were left with a thousand-fold more residual disease. These tumors were also significantly more likely to recur during the 80 days after treatment was stopped.

When the researchers investigated more closely, they found that it was the absence of a type of T cell called CD4 helper cells that was responsible for the differences in recurrence rates (28.5 percent of animals lacking CD4-positive cells had tumor recurrence vs. none in animals missing another type of T cell called a CD8-positive cell). After the researchers added CD4-positive cells to immunocompromised animals, the mice regained the ability to eliminate the tumor and none experienced tumor recurrence during the follow-up period.

Examining the tumor cells after Myc inactivation indicated that the differences in tumor regression and recurrence were not due to an inability of the immune-compromised animals to trigger tumor cell death (known as apoptosis) or to stop the cells from dividing. Rather, the cancer cells in the immunocompromised animals were less likely to slide into a state of inactivity called senescence and, unlike in the wild-type mice, continued to recruit new blood vessels to the tumor site (a process called angiogenesis).

"This was already provocative," said Felsher. "When the immune system was impaired, the treatment didn't work as well. But we then went a step further. We wanted to know specifically what it was about the CD4-positive cells that influenced tumor regression and recurrence."

They began by looking at signaling molecu
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Certain new therapies for age-related eye disease do not appear to increase heart risks
2. A revolutionary new way of reversing certain cancers
3. Bacteria identified that may lead to inflammatory bowel disease in certain individuals
4. Double-Dose Plavix Benefits Certain Patients, Study Finds
5. Alcohol intake increases certain types of breast cancer
6. Alcohol May Raise Risk for Certain Breast Cancers
7. UC Denver study finds beautiful women face discrimination in certain jobs
8. Certain meat components may increase bladder cancer risk
9. Study suggests link between scleroderma, cancer in certain patients
10. Smoking May Boost Risk of Certain Colon Cancers
11. Certain obese people are not at high risk of heart disease, diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... Earlier this week, the big announcement that fans of music was ... iHeartRadio Music Festival on Sept. 19 and 20 from the ... of music will have an act they are excited to see ... of Taylor Swift, as well as Zac Brown Band and Eric ... Grande, and Iggy Azalea, while R&B fans will be excited to ...
(Date:7/26/2014)... gas chromatography reagents report defines and segments the concerned market ... chromatography reagents market in Europe is valued at $ 314.8 ... $445.5 million by 2018, at a CAGR of 8.6 %, ... the European gas chromatography reagents market, to get an idea ... glimpse of the segmentation of gas chromatography reagents market in ...
(Date:7/26/2014)... 26, 2014 As reported by ... changing based on 3 factors: smaller spaces, multi-generational access, ... bathroom trend of 2014 lists, including this article ... Amerec , a leading manufacturer of steam bath ... largely due to smaller spaces and an effort to ...
(Date:7/26/2014)... New York, New York (PRWEB) July 26, 2014 ... continue to be filed in U.S. courts, Bernstein ... calling on federal health regulators to ban uterine morcellation. ... individuals include a 46-year-old mother of four from California ... of uterine cancer called leiomyosarcoma just 10 days after ...
(Date:7/26/2014)... July 26, 2014 We’ve all ... the playing field; however, concussions in the workplace ... occupations with the highest risk of head injury ...     Firefighters ,     Police officers ,     Race ...     Delivery personnel , “Most ...
Breaking Medicine News(10 mins):Health News:iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival for Sept. 19 & 20th 2Health News:iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival for Sept. 19 & 20th 3Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 5Health News:Amerec Finds Bathroom Design Trends Change Based on Water Consumption and Other Factors 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes New Calls for Ban on Uterine Mocellation In Light of Cancer Risk 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes New Calls for Ban on Uterine Mocellation In Light of Cancer Risk 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes New Calls for Ban on Uterine Mocellation In Light of Cancer Risk 4Health News:KORT Physical Therapists Take the Mystery Out of Identifying and Treating Workplace Head Injuries 2Health News:KORT Physical Therapists Take the Mystery Out of Identifying and Treating Workplace Head Injuries 3
... targeted searches to ob/gyn specialty-specific ... patient care and practice management, ... (http://www.OBGManagement.com ), a leader in the field of obstetrics ... latest search engine tool: OBGfindit.com (http://www.OBGfindit.com )., ...
... discovered a new perspective in the study of infectious ... looking at an organism and how it works within ... published in Environmental Microbiology, Dr Carla Pruzzo, Dr Luigi ... bacteria and its interaction with the environment and found ...
... Sharp Rise in Gonorrhea Cases, HARRISBURG, Pa., May 2 ... of Gonorrhea last year in Delaware County,the Pennsylvania Department of ... and 24 be routinely screened for the,disease, as well as ... to 921 in 2007 from 513,the year before., Of ...
... (Nasdaq:,WBMD) and HLTH Corporation (Nasdaq: HLTH ) today ... the Third Annual Needham & Company,Internet & Digital Media ... ET., Investors, analysts and the general public are ... presentation over the Internet. The broadcast,can be accessed at ...
... Lupus Foundation of,America joins a coalition of approximately 100 ... May 10. More than 1.5 million,Americans and at least ... struggle daily with the often-debilitating health,consequences of the chronic ... an unbalanced immune system that can become,destructive to any ...
... DIEGO, May 2 /PRNewswire-USNewswire/ - It is the cosmetic ... from their hips and thighs and,redistributing it to their ... or effective. Fat grafting for breast enhancement will be,discussed ... American Society,for Aesthetic Plastic Surgery (ASAPS) being held at ...
Cached Medicine News:Health News:OBGManagement.com and Convera(R) Launch Search Site for Physicians in the ObGyn Specialty 2Health News:Lupus Organizations Issue International Call-to-Action to Combat Disease Affecting Five Million People 2Health News:Breast Enhancement With Fat: Pros and Cons 2Health News:Breast Enhancement With Fat: Pros and Cons 3
(Date:7/25/2014)... 2014 /PRNewswire-iReach/ -- "Australia Capsule Endoscopy Systems Market Outlook ... Capsule Endoscopy Systems market. The report provides value, in ... prices (in US dollars) within market segments: ... Capsule Endoscopes , Capsule Endoscopy Data Recorders ... also provides company shares and distribution shares data for ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- ScriptPro, ... TCGRx, of Powers Lake, Wisconsin ... in a distribution and co-marketing agreement allowing ScriptPro ... pharmacies throughout the United States ... pharmacy management and workflow systems to retail and ...
(Date:7/25/2014)... , July 25, 2014 GrowBLOX Sciences, Inc. (OTCQB: ... Memorandum of Understanding ("MOU") with LaurelCo, LLC, an ... acquisition of both cultivation and dispensary medical marijuana licenses in ... the MOU, GBLX will acquire a 20% equity interest in ... GrowBLOX TM growing chambers, as well as all technology ...
Breaking Medicine Technology:Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 2ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 3GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 3
... YORK, Feb. 28, 2012  On February 28th, 2012, the ... for those interested in speaking at its 2012 Digital ... New York City,s Pier Sixty. At ... in New York City—over 600 healthcare providers, healthcare technology ...
... Feb. 28, 2012   Alexander Orthopaedic Associates (AOA) in ... in their practice with White Plume Technologies between ... Systems, (ADSC) practice management system (PM system). ... gaps in the billing process unfilled. White Plume Technologies ...
Cached Medicine Technology:Call for Speakers: New York's Digital Health Conference 2012 2Alexander Orthopaedic Associates Chooses White Plume Technologies to Fill the EMR Gap 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: