Navigation Links
Certain cancer therapies' success depends on presence of immune cell, Stanford study shows in mice
Date:10/27/2010

ll of us had assumed that most of the effects we saw on the tumor were relatively independent of the microenvironment of the host."

In contrast, Felsher and his colleagues found that disabling an oncogene called Myc in mice with Myc-dependent leukemias caused complete regression of tumors only in mice with intact immune systems. Tumors in mice with completely or partially compromised immune systems shrank more slowly and were left with a thousand-fold more residual disease. These tumors were also significantly more likely to recur during the 80 days after treatment was stopped.

When the researchers investigated more closely, they found that it was the absence of a type of T cell called CD4 helper cells that was responsible for the differences in recurrence rates (28.5 percent of animals lacking CD4-positive cells had tumor recurrence vs. none in animals missing another type of T cell called a CD8-positive cell). After the researchers added CD4-positive cells to immunocompromised animals, the mice regained the ability to eliminate the tumor and none experienced tumor recurrence during the follow-up period.

Examining the tumor cells after Myc inactivation indicated that the differences in tumor regression and recurrence were not due to an inability of the immune-compromised animals to trigger tumor cell death (known as apoptosis) or to stop the cells from dividing. Rather, the cancer cells in the immunocompromised animals were less likely to slide into a state of inactivity called senescence and, unlike in the wild-type mice, continued to recruit new blood vessels to the tumor site (a process called angiogenesis).

"This was already provocative," said Felsher. "When the immune system was impaired, the treatment didn't work as well. But we then went a step further. We wanted to know specifically what it was about the CD4-positive cells that influenced tumor regression and recurrence."

They began by looking at signaling molecu
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Certain new therapies for age-related eye disease do not appear to increase heart risks
2. A revolutionary new way of reversing certain cancers
3. Bacteria identified that may lead to inflammatory bowel disease in certain individuals
4. Double-Dose Plavix Benefits Certain Patients, Study Finds
5. Alcohol intake increases certain types of breast cancer
6. Alcohol May Raise Risk for Certain Breast Cancers
7. UC Denver study finds beautiful women face discrimination in certain jobs
8. Certain meat components may increase bladder cancer risk
9. Study suggests link between scleroderma, cancer in certain patients
10. Smoking May Boost Risk of Certain Colon Cancers
11. Certain obese people are not at high risk of heart disease, diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... ... July 28, 2015 , ... ... as the sports medicine provider for the entire school district including Anderson County ... ACHS Athletic Director Rick Sallee, “Student safety and well-being are a top priority ...
(Date:7/27/2015)... ... July 28, 2015 , ... The National Association of Professional ... VIP Woman of the Year Circle. She is recognized with this prestigious distinction for ... boasting more than 700,000 members and over 200 operating Local Chapters. , “I’m pleased ...
(Date:7/27/2015)... ... July 27, 2015 , ... Interactive health education is ... this year Wound Care Advantage beta launched Luvo University, an online ... Customized learning paths allow for clinicians, physicians, hyperbaric technicians and non-clinical staff ...
(Date:7/27/2015)... (PRWEB) , ... July 27, 2015 , ... ... transformed the science of the little-known and incurable disease, facioscapulohumeral muscular dystrophy (FSHD), ... American Academy of Neurology (AAN). The FSHD care guideline is published today. ...
(Date:7/27/2015)... ... ... Looking to brush up on all the things you should be doing ... enhanced its Dental webpage with new materials, including user-friendly, educational videos, to help members ... to offering our 3.8 million members tools and resources to help them keep a ...
Breaking Medicine News(10 mins):Health News:KORT Physical Therapy Named Sports Medicine Provider for Anderson County School System 2Health News:KORT Physical Therapy Named Sports Medicine Provider for Anderson County School System 3Health News:NAPW Inducts Joanne Saniewski, Principal of the Frontier School District's Big Tree Elementary, Into its VIP Woman of the Year Circle 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 3Health News:First-Ever FSHD Evidence-based Care Guideline Published by the American Academy of Neurology 2Health News:Thinking about a Dental Check-up? Check out Horizon Blue Cross Blue Shield of New Jersey’s Enhanced Website for a Dental Download of Helpful Information 2
... Leverages Personal Health Care Utilization and Employee Data to ... WHO: Daryl Ashley, senior vice president and general ... Benefits Administration for Workscape, a leading ... Will be a featured presenter in the "Getting Personal -- ...
... and anchor ... depth, ... SN) Endoscopy Division today announced the launch of the,BIORAPTOR 2.3 PK Suture ... is featured at Smith & Nephew Endoscopy,s booth,at the American Academy of ...
... Care,Spending May More Than Double as Hospital Capacity Declines And Baby Boomer ... ... of over 70,million aging baby boomers could overwhelm the U.S. health care ... the,Boom Bust Health Care?," by management consulting firm Tefen USA., A ...
... to Invest in Your Teeth, VOORHEES, N.J., March ... should be similar for 2007. Together with the,government,s economic ... in the pockets of most taxpayers this Spring, it,s ... vacations., But rather than getting away for a ...
... Associate at Kendle ... International, Inc., Joins Catalyst, CORAL GABLES, Fla., March 5 ... the,appointment of Patrick Kenny as Director - Corporate Clinical Compliance.,In ... and GCP compliance of the CROs, clinical contractors and,clinical trial ...
... 1999,OurHealthNetwork.com ( http://www.OurHealthNetwork.com ) has been the,Internet,s leading ... board- certified podiatrists now introduces an exclusive line ... orthotics that not only,provide relief to those who ... their,lifestyles and shoe styles. Now for the first ...
Cached Medicine News:Health News:Upcoming Business Health Agenda 2008 Features Workscape Executive 2Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 2Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 3Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 4Health News:New Study: Aging Baby Boomers Could Overwhelm U.S. Health Care System by 2017, Unless Decisive Action Is Taken 2Health News:New Study: Aging Baby Boomers Could Overwhelm U.S. Health Care System by 2017, Unless Decisive Action Is Taken 3Health News:New Study: Aging Baby Boomers Could Overwhelm U.S. Health Care System by 2017, Unless Decisive Action Is Taken 4Health News:Smile When You Get that Refund 2Health News:Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance 2Health News:Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance 3Health News:Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance 4Health News:Unique Line of Custom-Made Orthotics for Sandals and Clogs Cater to Style-Minded Foot Pain Sufferers 2
(Date:7/27/2015)... and PITTSBURGH , July 27, 2015 /PRNewswire/ ... will hold its extraordinary general meeting of shareholders in connection ... PRGO ; TASE) at the Okura Hotel Amsterdam on Friday, ... Among other agenda items at the extraordinary ... approval, under article 2:107a of the Dutch Civil Code, of ...
(Date:7/27/2015)... , July 20, 2015 ... announced the addition of the "Cardiometabolic Drug ... Afrezza,s discounted pricing is in line with ... critical to the product,s commercial appeal. However, contraindications, ... Afrezza from gaining a sizeable share of the ...
(Date:7/27/2015)...  Linear accelerators used to treat patients with ... adequate space for the equipment itself, but also ... the size and complexity of the technology, full ... of a new vault constitutes a formidable undertaking ... patient treatment: with potential negative long-term effects for ...
Breaking Medicine Technology:Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 2Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 3Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 4Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 5Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 6Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 7Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 8Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 9Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 10Cardiometabolic Drug News Issue - Afrezza Aggressive Pricing Strategy View Playing Out 2Cardiometabolic Drug News Issue - Afrezza Aggressive Pricing Strategy View Playing Out 3Accelerating the Design Process for Cancer Treatment Centers 2Accelerating the Design Process for Cancer Treatment Centers 3
... 23, 2011 PharmacoFore, Inc., a privately held ... announced positive results from a Phase I human ... Molecular Delivery™ (Bio-MD™) product candidate, PF329.  Greg Sturmer, ... 2011 BIO Business Forum during the annual BIO ...
... Luminex Corporation (NASDAQ: LMNX ) has ... Most Innovative Company of the Year (for companies with ... Year for the MAGPIX System.  A record number of ... organizations from virtually all company sizes and industries.  In ...
Cached Medicine Technology:PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 2PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 3PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 4Luminex Corporation Named Most Innovative Company of the Year and Receives Business Innovation of the Year Award for MAGPIX® System 2Luminex Corporation Named Most Innovative Company of the Year and Receives Business Innovation of the Year Award for MAGPIX® System 3
Well established test for children but suitable for disabled people, those with learning difficulties or patients who do not share a common language with the examiner....
The FLEXI-CUT Directional Debulking System is Abbott Vascular's latest atherectomy catheter designed to enhance performance and ease-of-use....
This test displays normal protan, deutan and tritan colors, differentiation is stronger in the red/green., ,Significant tritan defects may be detected if used in conjunction with the Ishihara. Th...
The New Vantage Plus. The PLUS gives you: ,P Premium intelligent optics ,L Lighter weight and brighter images ,U Unique wireless patented technology ,S Smaller and more compact size ...
Medicine Products: