Navigation Links
Certain anti-cancer agents could be harmful to patients with heart disease
Date:6/24/2008

A set of promising new anticancer agents could have unforeseen risks in individuals with heart disease, suggests research at Washington University School of Medicine in St. Louis. The anticancer drugs which go by the strange name of hedgehog antagonists interfere with a biochemical process that promotes growth in some cancer cells. But the researchers showed that interfering with this biochemical process in mice with heart disease led to further deterioration of cardiac function and ultimately death.

"This finding should serve as a warning that these drugs might have adverse effects on the heart and that it could be very important to monitor patients' cardiovascular health when using this type of anticancer drug," says senior author David Ornitz, M.D., Ph.D., the Alumni Endowed Professor and head of Developmental Biology. The research was reported June 20, 2008, in advance online publication in the Journal of Clinical Investigation.

Hedgehog antagonists are drugs that inhibit the hedgehog signaling pathway, a chain of biochemical signals that regulate cellular growth and differentiation. The odd term hedgehog has little to do with the small, spiny mammals it originated when scientists noted the spiky, hedgehog-like appearance of fly embryos with abnormal hedgehog genes. Every organism in the animal kingdom has hedgehog genes, which play an essential role in guiding cells to mature into the appropriate form for proper function.

Ornitz and his research team, including lead author Kory Lavine, M.D., Ph.D., now a resident in the Cardiovascular Division of the Department of Medicine at Washington University School of Medicine, are on the forefront of research into how blood vessels in heart muscle develop in growing embryos. They recently found that the hedgehog signaling pathway was vital to the development of the heart's blood supply.

Now the Washington University research team has demonstrated that the hedgehog signal
'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Independence Blue Cross Waives Copays for Generics Used to Treat Certain Chronic Conditions
2. Women, Mexican Americans at Higher Risk for Certain Stroke
3. Raloxifene Cuts Risk of Certain Type of Breast Cancer
4. Consumers Urged to Avoid Certain Tomatoes Amid Salmonella Scare
5. Demonstrating the Value of Benchmarking in an Uncertain Economy
6. St. Jude finds young age may give survival advantage to children with certain brain tumors
7. Certain Tests in ERs Raise Cancer Risk for Some
8. Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer
9. Gypsum Wallboard from CertainTeeds Moundsville, W. Va., Plant and Roofing Shingles among Building Materials Donated to St. Jude Dream Home(R)
10. Regular prostate-specific antigen screening may be discontinued in certain elderly populations
11. Experimental drug shows promise in treating certain lymphomas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... (PRWEB) March 01, 2015 Heart diseases ... that 10 percent of urban adult population and 5 ... of heart diseases and 20-30 percent of them require ... heart ailments and coronary vascular diseases (CVD). , A ... a new market research report titled “Indian Coronary Stent ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 The ... is offering a new special. Throughout all of ... , This service can help ... problems and pain. Patients may notice certain symptoms that ... relining. These symptoms include: , 1.    Pain, clicking, and ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 A study ... promising new gene therapy procedure for the treatment of ... in patients. Authored by Dr. Robert MacLaren, ... published in the Lancet Medical Journal on January 16, ... choroideremia, a rare genetic disorder that mostly affects men ...
(Date:2/28/2015)... February 28, 2015 Dr. Perry ... Coast area residents, recently announced a special offer for ... a treatment option for new and established patients at ... with a bright, white smile, Dr. Patel and his ... $299, marked down from the regular price of $450. ...
(Date:2/28/2015)... York, NY (PRWEB) February 28, 2015 On ... Phishing Kits Make It Easy For Scammers To Steal Your ... anyone can get their hands on a DIY phishing kit, ... But it also touched on another important point about how ... these kits are often implemented, “like compromising legitimate content management ...
Breaking Medicine News(10 mins):Health News:India Coronary Stent Market 2019 Forecasts Analysis in New Research Report Available at MarketReportsOnline.com 2Health News:India Coronary Stent Market 2019 Forecasts Analysis in New Research Report Available at MarketReportsOnline.com 3Health News:Classic Denture Center in Portland Oregon is Offering March Discount 2Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2Health News:Pismo Beach Dentist Announces Special for Zoom! Teeth Whitening 2Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 2Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 3Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 4
... FRIDAY, March 18 (HealthDay News) -- Obstructive sleep apnea may ... with enlarged prostates, a new study suggests. The study ... benign prostate enlargement (BPE) and reported nighttime urination (nocturia) at ... of same-age men who had no BPE and one or ...
... 18 (HealthDay News) -- Women in smoke-free homes and ... breast cancer, new research shows. U.S. researchers compared ... of breast cancer incidence and death. States with higher ... breast cancer deaths, particularly among younger premenopausal women. ...
... College of Radiology,s Imaging Network (ACRIN) and the ... (NCI) Clinical Trials Cooperative Group members, today announced ... programs. The groups plan to form ... new organization will include three areas of research ...
... with different terms to describe a clinical trial, parents were far ... called a "research study" than if it was called a "medical ... the former as safer, even though that was not necessarily the ... Human Research . Terms such as these are ...
... News) -- Anti-drug ads appear to be an effective way ... the United States, a new study has found. In ... Influence" anti-drug campaign, researchers analyzed the relationship between exposure to ... students in grades 8, 10 and 12. The campaign ...
... The federal Centers for Disease Control and Prevention ... Health & Hospitals System and Rush University Medical ... successful program aimed at preventing healthcare-associated infections, antibiotic ... The project, dubbed the Chicago Antimicrobial Resistance and ...
Cached Medicine News:Health News:Sleep Disorder May Spur Men to Head to Bathroom at Night 2Health News:Biomarker-driven science at the heart of new ACRIN-ECOG structure 2Health News:Biomarker-driven science at the heart of new ACRIN-ECOG structure 3Health News:Terminolgy matters in parents' willingness to enroll their children in research 2Health News:CDC, Cook County and Rush collaborate to research and prevent hospital infections 2Health News:CDC, Cook County and Rush collaborate to research and prevent hospital infections 3Health News:CDC, Cook County and Rush collaborate to research and prevent hospital infections 4
(Date:2/27/2015)... HILL, N.C. , Feb. 27, 2015 ... over the past decade but one thing hasn,t changed: ... MSLs to build relationships with Key Opinion Leaders. ... recognized as the most valuable type of interaction, field ... limits on their KOL interactions. This is just one ...
(Date:2/27/2015)... , Feb. 27, 2015  Pharmacyclics, Inc. ... from a pre-clinical study published in the ... ( www.pnas.org/cgi/doi/10.1073/pnas.1500712112 ) that showed when ibrutinib (IMBRUVICA ... (a checkpoint inhibitor), suppression of tumor growth was ... when treating certain hematologic cancers and solid tumors ...
(Date:2/27/2015)... TEL-AVIV , Israele, February 27, 2015 /PRNewswire/ ... continua nel suo sviluppo dell,innovativo sistema di monitoraggio ... il primo trial sull,uomo-   ... operante nello sviluppo di nuovo sistema per il ... congestizio (CHF), ha annunciato oggi di aver concluso ...
Breaking Medicine Technology:Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 3In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 4In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 5In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 6In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 7In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 8In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 9Vectorious Medical Technologies completa una raccolta di 5 milioni di dollari 2
... ResMed Inc. (NYSE: RMD ) today announced results ... quarter ended September 30, 2011 was a record $314.8 million, ... basis) over the quarter ended September 30, 2010.  For the ... Largely as a result of currency exchange rate movements, net ...
... of the most crucial components of a successful new ... relationships with the FDA. However, while building a collegial and ... the FDA is not always an easy task, not doing ... study participant, a Regulatory Affairs Executive Director at a leading ...
Cached Medicine Technology:ResMed Inc. Announces Financial Results for the Quarter Ended September 30, 2011 2ResMed Inc. Announces Financial Results for the Quarter Ended September 30, 2011 3ResMed Inc. Announces Financial Results for the Quarter Ended September 30, 2011 4ResMed Inc. Announces Financial Results for the Quarter Ended September 30, 2011 5ResMed Inc. Announces Financial Results for the Quarter Ended September 30, 2011 6Recent Research Provides Formula for Timely Product Launch: Good Science + Effective FDA Relations 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: