Navigation Links
Certain Painkillers Appear to Boost Odds for Heart Attack
Date:1/12/2011

By Steven Reinberg
HealthDay Reporter

TUESDAY, Jan. 11 (HealthDay News) -- Common painkillers taken to treat inflammation, such as Celebrex and Advil, can raise the risk of heart attack, stroke or death, a review of existing research suggests.

Swiss researchers analyzed the results of 31 trials involving seven non-steroidal anti-inflammatory drugs (NSAIDs), as these medications are called, and concluded that cardiovascular risk needs to be considered before prescribing any of them.

"NSAIDs are widely used worldwide for treating pain and inflammation," said Dr. Gregg Fonarow, American Heart Association spokesman and professor of cardiology at the University of California, Los Angeles.

"A number of studies have shown that many of these agents are associated with increased risk of cardiovascular events, particularly when used at higher doses and for longer periods of time, but uncertainty remains as to the magnitude of the risk and how the cardiovascular risk may vary among different NSAIDs," said Fonarow, who was not involved in the study.

All the NSAIDs studied increased the risk of cardiovascular events, but the magnitude of risk is small in absolute terms -- approximately one cardiovascular event per 100 patient-years of follow-up, Fonarow noted.

"In many patients the benefits provided by these agents may outweigh the risk, and other steps can be taken to reduce the patient's cardiovascular risk," he said.

The report is published in the Jan. 11 online edition of the BMJ.

In 2004, the drug Vioxx (rofecoxib), which belonged to a class of NSAIDs called COX-2 inhibitors, was pulled from the market because of its link to an increased risk of heart attack.

To explore the connection between NSAIDs and heart problems, a team led by Dr. Peter Juni, from the Institute of Social and Preventive Medicine at the University of Bern, reviewed 31 trials that included 116,429 patients. This method of reviewing trial findings to uncover a pattern is called a meta-analysis.

The painkillers the patients were taking included naproxen (Aleve), ibuprofen (Advil, Motrin), diclofenac (Voltaren, Cataflam), celecoxib (Celebrex), etoricoxib (Arcoxia), rofecoxib (Vioxx), lumiracoxib (Prexige) or placebo.

Overall, the number of heart events among patients taking NSAIDs was low, the researchers found. In 29 trials, 554 heart attacks occurred. In 26 trials, 377 strokes were reported, and in 28 trials, 676 people died.

Compared with patients taking placebo, those taking rofecoxib and lumiracoxib had twice the risk of heart attack, and those taking ibuprofen had more than three times the risk of stroke. The highest risks for cardiac death were associated with etoricoxib and diclofenac, where the risk was around four times greater than for placebo, the researchers found.

Naproxen appeared to be the least harmful medication, they noted.

"Our study provides the best available evidence on the safety of this class of drugs," the researchers wrote. "Although uncertainty remains, little evidence exists to suggest that any of the investigated drugs are safe in cardiovascular terms. Cardiovascular risk needs to be taken into account when prescribing any non-steroidal anti-inflammatory drug," they concluded.

Commenting on the study, Dr. Eric J. Topol, director of the Scripps Translational Science Institute and one of the experts who uncovered the risks associated with Vioxx, said a meta-analysis can leave many questions unanswered but is of value nonetheless.

"Pooling large data sets like this winds up with ambiguity as it homogenizes differences in patient population characteristics, dose of drugs, how endpoints were ascertained and when, etc.," he said. "I am not sure if the conclusions reflect or agree with other meta-analysis results," Topol noted.

"Despite the limitations, this study has made many excellent contributions on the NSAID issue, so we need to factor these into the mix," Topol said.

More information

For more information on NSAIDs, visit the U.S. Food and Drug Administration.

SOURCES: Eric J. Topol, M.D., director, Scripps Translational Science Institute, La Jolla, Calif.; Gregg Fonarow, M.D., American Heart Association spokesman, and professor, cardiology, University of California, Los Angeles; Jan. 11, 2011, BMJ, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Certain pain medications do not appear to be associated with skin cancer risk
3. AGA offers new recommendations for CRC surveillance for certain patients with IBD
4. Smoking significantly increases risk of aneurysm in people with certain genes
5. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
6. Certain Bone Drugs May Lower Breast Cancer Risk
7. Football Injuries More Likely on Certain Artificial Turf
8. Plavix Can Help Cut Death Risk in Certain Heart Patients
9. The Worst Is Over, but the Road to Growth Is Uncertain - The 17th Annual CFO Rising Conference & Exhibition
10. Perhaps a longer lifespan, certainly a longer health span
11. One in Five Parents Would Spank in Certain Settings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Certain Painkillers Appear to Boost Odds for Heart Attack
(Date:2/24/2017)... ... ... Dr. Ronald E. Hawkins, vice president for academic affairs ... Bell, DO, MBA, HPF, FACOEP-dist., FACEP, as the new dean of Liberty ... to Liberty from the Ohio University Heritage College of Osteopathic Medicine (OU-HCOM), where ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: ... ’s true account of his paramedic experiences. Schanssema describes the tragedies he saw, as ... attempts to overcome them. , Schanssema, initially unsure of the career path he wanted ...
(Date:2/24/2017)... ... , ... Indiana Fiber Network (IFN) President and CEO Kelly C. Dyer recently ... as the Chairman of the Management Committee when IFN was originally formed in 2002 ... of investor/owners and development of the business plan. He became the first paid ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the most ... Jensie Gran Fondo of Marin. For the second year in a row, cyclists ... sunscreen. , “We are thrilled to provide our safe, non-toxic sunscreen to over ...
(Date:2/23/2017)... ... February 23, 2017 , ... The American Cleft Palate-Craniofacial Association (ACPA) is pleased ... KLS is a longtime supporter of the event. , "We are pleased that KLS ... Dr. Bob Havlik, 2017 ACPA President. "KLS Martin has a long track record of ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Feb. 24, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the Cowen and Company 37 ... Marriott Copley Place on Tuesday, March 7, 2017 at ... webcast of the presentation can be accessed at ... following the conference via Zimmer Biomet,s Investor Relations website ...
(Date:2/24/2017)... , Feb. 24, 2017  In conjunction with ... 2016 financial results press release, you are invited to ... live over the internet on Tuesday, March 14, 2017 ... A live audio webcast of the presentation ... www.durect.com and clicking "Investor Relations."  If you are ...
(Date:2/24/2017)... 24. Februar 2017 ITL Limited, ( ... Gesundheitsbereiches, ist erfreut, für das zum 31. Dezember ... Vorjahreszeitraum exzellente Ergebnisse vorlegen zu können. Eine vollständige ... Wachstum" finden Sie hier . ... Steuern 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
Breaking Medicine Technology: