Navigation Links
Certain Genetic Regions May Be Tied to Osteoporosis
Date:4/16/2012

SUNDAY, April 15 (HealthDay News) -- A large international group of researchers has identified 32 new genetic regions linked to fractures and osteoporosis.

Variations in these regions could offer protection from, or greater risk for, bone-weakening disease, the investigators reported in a new study published in the April 15 online edition of Nature Genetics.

The study authors added that their findings could lead to the development of new osteoporosis drugs.

"We're learning that the genetic architecture of disease is very complex," one of the study's authors and the methodological leader of the consortium, Dr. John Ioannidis, chief of the Stanford Prevention Research Center, said in a university news release.

The research, which involved 17 studies that compared common genetic variants in more than 100,000 people, pinpointed six regions linked to risk of fractures of the femur (thigh bone) or lower back.

The study authors pointed out, however, that it would still be difficult to predict who is at greater risk for bone disease. People with the highest number of variants associated with decreased bone mineral density were only about one and a half times more likely than people with an average number of variants to have osteoporosis. The risk for fractures was only slightly higher.

Meanwhile, compared to those with the fewest variants, people with the most variants were still just three to four times more likely to have had fractures and lower bone mineral density, the study revealed.

"As a result, the next step of incorporating this information into basic patient care is not clear," Ioannidis concluded. "Each variant conveys a small quantum of risk or benefit. We can't predict exactly who will or won't get a fracture."

The authors noted, however, that by identifying some previously unsuspected pathways involved in bone health, their research could lead to the development of new anti-osteoporosis drugs. But even larger studies are needed to identify all of the genes critical to fighting bone disease, they added.

"We saw many of these regions and genes clustering within specific types of pathways, which suggests certain disease mechanisms. It certainly wouldn't be unexpected to eventually identify many more genetic regions involved in the regulation of osteoporosis and fracture risk," Ioannidis said.

"In reality, there may be 500 or more gene variants regulating osteoporosis. To find all of them, we'll need to study millions of patients. Is this unrealistic? I don't think so. Sooner or later this will be feasible," he added.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about bone-weakening diseases.

-- Mary Elizabeth Dallas

SOURCE: Stanford University School of Medicine, news release, April 15, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Decision guide reduced uncertainty over breast cancer prevention, study finds
2. Codeine After Surgery Could Endanger Certain Kids: Study
3. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
4. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
5. Certain Antipsychotics Up Risk of Death for Patients With Dementia: Study
6. Certain Cancer Drugs May Have Fatal Side Effects: Analysis
7. Women with certain type of ovarian cancer and BRCA gene mutation have improved survival at 5 years
8. Certain Seniors at Risk for Infection After ER Visit: Study
9. Certain Diabetes Drugs Might Aid Weight Loss
10. Abiraterone: Indication of considerable added benefit in certain patients
11. FDA Curbs Use of Certain Antibiotics in Livestock, Poultry
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Certain Genetic Regions May Be Tied to Osteoporosis
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
Breaking Medicine Technology: