Navigation Links
Certain Formulations of Omega-3s Might Help With Depression
Date:12/9/2010

By Jenifer Goodwin
HealthDay Reporter

WEDNESDAY, Dec. 8 (HealthDay News) -- Omega-3 fatty acids may help alleviate depression but only when a particular type of fatty acid called DHA is used in the right ratio with another fatty acid known as EPA, a new study suggests.

The researchers analyzed the results of some 15 previous controlled clinical trials on the use of omega-3s -- commonly found in oily fish or in fish oil supplements -- to treat depressed people.

They found that when used by itself, DHA (docosahexaenoic acid) alone did not seem to offer any benefit. However, DHA combined with a rather high dose of EPA (eicosapentenoic acid) did improve depressive symptoms.

"Preparations with some EPA had some consistent antidepressant effects, while preparations of pure DHA had no antidepressant effects," said lead study author Dr. John Davis, a professor of psychiatry at the University of Illinois at Chicago. "I don't think we can prove it beyond a shadow of a doubt, but there is now evidence from a number of double-blind studies that suggest mixed DHA/EPA has antidepressant properties, whether by itself or given along with traditional antidepressants."

The study, funded by the U.S. National Institutes of Health, was designed as a meta-analysis, in which researchers combine the results of multiple prior studies. The findings were slated for presentation Thursday at the American College of Neuropsychopharmacology meeting in Miami.

Davis noted the next step should be to test the anti-depressant effect of the omega-3 fatty acid combination in a large population to establish a dose range.

Prior research on the effectiveness of omega-3 fattys acids against depression has been mixed, with one recent randomized, placebo-controlled clinical trial in the Journal of the American Medical Association, for example, concluding that taking 800 milligrams of DHA daily did not help ward off depression in pregnant women.

Epidemiological studies, in which researchers look for associations across populations, have linked DHA deficiencies to depression. However, it's unknown if the depressed people in the study were DHA-deficient and therefore the supplements were simply returning their DHA levels to normal, or if an added boost of DHA/EPA was helpful even for those with sufficient levels, Davis said.

Also unknown is whether depressed individuals could use a DHA/EPA combination instead of standard antidepressant medications or if it could or should be used to augment other medications, said Edythe London, a professor of psychiatry and pharmacology at University of California, Los Angeles.

London cautioned that depressed individuals should certainly not rely on fish oil supplements alone.

"The consistent finding is omega-3 fatty acids can improve the mood of people who have depression symptoms," London said. "But depression is a very serious disorder. If someone is depressed, they should not just buy something off the shelf and rely only on that. They should be evaluated by their mental health professional who can determine the most appropriate course of therapy."

And DHA/EPA did not improve the mood of study participants who were not depressed, Davis noted.

Cold-water oily fish such as salmon, tuna, sardines, trout and herring contain both DHA and EPA. A few other foods contain those nutrients as well, including nuts, soybeans and flaxseed.

Fish oil supplements containing DHA are also among the most popular supplements, Davis said. He recommended people look for one that has relatively equal amounts of both EPA and DHA.

Since the findings are to be presented at a medical meeting, they should be considered preliminary until published in a peer-reviewed journal.

More information

The U.S. National Institute of Mental Health has more on depression.

SOURCES: John Davis, M.D., professor, psychiatry, University of Illinois at Chicago; Edythe London, Ph.D., professor, psychiatry and pharmacology, University of California, Los Angeles, Los Angeles, Calif.; meeting, American College of Neuropsychopharmacology meeting, Dec. 8, 2010, Miami


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Certain pain medications do not appear to be associated with skin cancer risk
3. AGA offers new recommendations for CRC surveillance for certain patients with IBD
4. Smoking significantly increases risk of aneurysm in people with certain genes
5. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
6. Certain Bone Drugs May Lower Breast Cancer Risk
7. Football Injuries More Likely on Certain Artificial Turf
8. Plavix Can Help Cut Death Risk in Certain Heart Patients
9. The Worst Is Over, but the Road to Growth Is Uncertain - The 17th Annual CFO Rising Conference & Exhibition
10. Perhaps a longer lifespan, certainly a longer health span
11. One in Five Parents Would Spank in Certain Settings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Certain Formulations of Omega-3s Might Help With Depression
(Date:6/20/2017)... ... June 20, 2017 , ... John D'Eri, CEO of Rising ... in Adult Autism Award during the Autism Society of America 's 49th ... The Daniel Jordan Fiddle Foundation (DJFF) was founded in 2002 as the nation's ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... bedside, would like to officially welcome Anthony Stanowski, DHA, FACHE to the MEDI+SIGN ... whose insight and expertise in healthcare will provide invaluable direction for the company,” ...
(Date:6/20/2017)... ... June 20, 2017 , ... The law firm of Momkus ... as the president of the DuPage County Bar Association’s Board of Directors. Cassioppi officially ... 9 at the Drake in Oak Brook. Momkus McCluskey Roberts LLC attorney Stacey A. ...
(Date:6/20/2017)... ... 20, 2017 , ... As part of an effort coordinated by more than ... has provided input to the U.S. Senate on health care reform. , The group ... E. Schumer (D - NY) and all other Senate members. This correspondence provides legislators ...
(Date:6/19/2017)... , ... June 19, 2017 , ... ... brand new operating rooms this month. These additions will expand the capabilities of ... state-of-the-art facilities. One operating room will be solely dedicated to pediatric operations, while ...
Breaking Medicine News(10 mins):
(Date:6/12/2017)... June 12, 2017 Kineta, Inc., a biotechnology company ... Kineta Vice President of R&D and Head of Virology ... Pandemic Preparedness for the Northwest and Beyond meeting sponsored ... June 14, 2017 from 8:30-10:30 AM PDT at the Agora ... Dr. Bedard will be joined by other leaders ...
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... June 6, 2017  Diplomat Specialty Infusion Group, a brand of ... to its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound ... a low level of pollutants. ... consumers and better serve our Iowa patients," ...
Breaking Medicine Technology: