Navigation Links
Certain Antipsychotics Up Risk of Death for Patients With Dementia: Study
Date:2/23/2012

THURSDAY, Feb. 23 (HealthDay News) Compared to other antipsychotic drugs, haloperidol (Haldol) raises the risk of death in elderly patients with dementia, a new study finds.

One outside expert believes the finding should aid in dementia care. "This data provides much-needed guidance and reassurance for the ever-increasing number of health care practitioners treating older demented patients," said Dr. Gisele Wolf-Klein, director of geriatric education at the North Shore-LIJ Health System in New Hyde Park, N.Y.

The study was published online Feb. 23 in the British Medical Journal.

In 2005, the U.S. Food and Drug Administration warned that certain antipsychotic drugs are associated with an increased risk of death in elderly patients with dementia. This warning was expanded to include conventional antipsychotics in 2008, according to a journal news release.

The authors of the new study said that, despite the FDA action, the use of antipsychotic drugs for this patient population is likely to grow. According to the Harvard Medical School researchers, that's because there are a growing number of elderly patients with dementia who require some type of treatment.

Wolf-Klein agreed, noting that safety concerns over the use of antipsychotics are "leaving primary care physicians, geriatricians, neurologist and psychiatrists in a quandary as they attempt to respond to overwhelmed caregivers dealing with unmanageable behaviors at home. Discussion with family members of the risks and benefits of atypical antipsychotics creates additional stress and burden in an already difficult situation."

In the study, the Harvard group examined 2001-2005 data from more than 75,000 nursing home residents, aged 65 and older, in facilities across 45 states. They sought to assess the risk of death associated with widely used antipsychotic drugs such as aripiprazole, haloperidol, olanzapine, quetiapine, risperidone and ziprasidone.

During the six-month study period, about 6,600 of the nursing home residents died from causes that were unrelated to cancer. Those who took haloperidol had double the risk of death compared to those who took risperidone, while those who took quetiapine (Seroquel) had a lower risk of death.

The researchers found that the effect of haloperidol was strongest during the first 40 days of treatment and that this did not change after doses were adjusted. Circulatory disorders accounted for 49 percent the deaths, respiratory disorders for 15 percent and brain disorders for 10 percent.

Not all antipsychotic medications carry the same risk of death in elderly patients and doctors "may want to consider this evidence when evaluating ... the best approach to treatment of behavioral problems," the researchers wrote.

Wolf-Klein said the study offers doctors valuable guidance going forward, and she called it "a landmark approach to addressing the pressing clinical need of practicing physicians confronted with behavioral issues in elderly demented patients."

More information

The American Academy of Family Physicians has more about dementia.

-- Robert Preidt

SOURCES: Gisele Wolf-Klein, M.D., director, geriatric education, North Shore-LIJ Health System, New Hyde Park, N.Y.; British Medical Journal, news release, Feb. 23, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Certain pain medications do not appear to be associated with skin cancer risk
3. AGA offers new recommendations for CRC surveillance for certain patients with IBD
4. Smoking significantly increases risk of aneurysm in people with certain genes
5. American Stroke Association Late-Breaking Science Report: Surgery, Stenting to Open Blocked Neck Arteries Similar in Safety, Efficacy, But Show Differences in Stroke, Heart Attack and Death Rates at Certain Ages
6. Certain Bone Drugs May Lower Breast Cancer Risk
7. Football Injuries More Likely on Certain Artificial Turf
8. Plavix Can Help Cut Death Risk in Certain Heart Patients
9. The Worst Is Over, but the Road to Growth Is Uncertain - The 17th Annual CFO Rising Conference & Exhibition
10. Perhaps a longer lifespan, certainly a longer health span
11. One in Five Parents Would Spank in Certain Settings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Certain Antipsychotics Up Risk of Death for Patients With Dementia: Study
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson ... offers insurance and financial preparation services, is providing an update on a charitable ... , Rock City Rescue is a locally recognized nonprofit that provides shelter and ...
(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
Breaking Medicine Technology: