Navigation Links
Cerimon to Conduct a Proof of Concept Study for Basiliximab for Noninfectious Uveitis, a Potentially Sight-Threatening Inflammation of the Eye
Date:3/10/2008

SOUTH SAN FRANCISCO, Calif., March 10 /PRNewswire/ -- Cerimon Pharmaceuticals announced today it has entered into an agreement with Novartis Pharma AG to conduct a proof of concept study for Simulect(R) (basiliximab) for the treatment of noninfectious uveitis, an autoimmune inflammation of the eye's internal structures. Uveitis can cause severe visual impairment and accounts for an estimated 10 percent of blindness cases in the Western World. Basiliximab is a monoclonal antibody that selectively blocks the interleukin-2 (IL-2) receptor. This mechanism of action provides highly targeted inhibition of the T-lymphocyte activation that is involved in serious immune-related diseases.

"There is a significant need for new effective therapies for the treatment of noninfectious uveitis patients. Part of Cerimon's overall strategy is to expand our basiliximab development program into other autoimmune diseases where there is significant medical need," commented Paul Sekhri, President and CEO of Cerimon Pharmaceuticals. "The agreement also exemplifies our strong relationship with Novartis, one of the leading worldwide pharmaceutical companies."

Dr. Daniel Levitt, Cerimon's Executive Vice President of Research and Development, stated, "Based on the mechanism of action of basiliximab, we believe this compound is well-suited to the treatment of noninfectious uveitis, a chronic eye inflammation that can lead to complications such as glaucoma, cataract, and vision loss. Basiliximab has the potential to significantly improve the quality of life for this group of uveitis patients and reduce adverse events often associated with current treatments that include corticosteroids and other immunosuppressive therapies."

In February 2006, Cerimon licensed basiliximab from Novartis for the treatment of Inflammatory Bowel Disease (IBD). In April 2007, Cerimon initiated a Phase IIb clinical study, titled ARREST UC-1 (Achieve Remission & Reduce or Eliminate Steroid Therapy in Ulcerative Colitis), for the treatment of ulcerative colitis, a common type of IBD.

About Autoimmune Uveitis

Uveitis is an inflammation of the internal structures of the eye. There are two types of uveitis, infectious and noninfectious. Noninfectious uveitis is believed to be the result of an autoimmune disorder. Autoimmune uveitis affects approximately 175,000 people in the United States and can lead to blindness. Current treatments include topical and oral corticosteroids and immunosuppressive drugs; however, these generally have limited success and can lead to adverse effects.

About Cerimon Pharmaceuticals

Cerimon Pharmaceuticals, Inc., is a biopharmaceutical company dedicated to developing and commercializing therapeutic products for autoimmune diseases, inflammation, and pain. Cerimon believes these new treatment options will enable physicians specialized in treating these conditions to further improve the lives of their patients.

Cerimon currently has two drugs in development. Simulect(R) (basiliximab) entered a Phase IIb study for moderate-to-severe ulcerative colitis in the April 2007. In late fourth quarter 2007, Cerimon's topical patch formulation of diclofenac entered two Phase II/III clinical studies for the treatment of acute musculoskeletal pain.

The Company is well-financed, having closed a $70 million Series A financing in late 2005 with premier investors including MPM, Nomura Phase4 Ventures, and OrbiMed Advisors.

For more information on Cerimon, please visit the Company's website at http://www.cerimon.com.


'/>"/>
SOURCE Cerimon Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. SpineMark, NeuStrategy Partner to Conduct Nations First Spine COE Survey(TM)
2. Nursing Home Workers Strike Over Employer Misconduct
3. Parents Identify Health Topics They Want Doctors to Discuss with Kids - New Research for University of Michigan Conducted by Knowledge Networks
4. inVentiv Health to Announce Fourth Quarter and Full Year 2007 Results and Conduct Conference Call on Thursday, February 28th
5. The Willie Gary Law Firm Files $1 Billion Lawsuit Against Durham County LME, Wake County LME, Five County LME, Mecklenberg County LME and Value Options, Inc. for Negligent and Intentional Misconduct Against Mental Health Agency
6. Doctors Group Sues Texas Medical Board for Misconduct; Cites Institutional Culture of Retaliation & Intimidation
7. Heavy drinking, conduct disorder linked to high-risk sexual behavior
8. Micromet Receives Regulatory Approval to Conduct a Phase 2 Clinical Trial Investigating MT103 (MEDI-538) in Patients with Acute Lymphoblastic Leukemia
9. Novel semiconductor structure bends light wrong way -- the right direction for many applications
10. CareTech Solutions Executive to Conduct Presentation on Creating a Healthy Revenue Cycle at AHIMA Convention and Exhibit
11. inVentiv Health to Announce Third Quarter Results and Conduct Conference Call on Wednesday, November 7, 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/12/2017)... 12, 2017  Consumer reviews on the independent review site ... number one company for hearing aids, ranking it higher than ... ... by Consumers For Hearing Aids ... is an online store that provides high performance, state-of-the-art, German-engineered hearing ...
Breaking Medicine Technology: