Navigation Links
Cerebrospinal fluid shows Alzheimer's disease deterioration much earlier

It is possible to determine which patients run a high risk of developing Alzheimer's disease and the dementia associated with it, even in patients with minimal memory impairment. This has been shown by recent research at the Sahlgrenska Academy, University of Gothenburg, Sweden.

The results have been published in the most recent issue of the prestigious medical journal Lancet Neurology.

"The earlier we can catch Alzheimer's disease, the more we can do for the patient. The disease is one that progresses slowly, and the pharmaceuticals that are currently available are only able to alleviate the symptoms", says Kaj Blennow, professor at the Sahlgrenska Academy, and a world?leading researcher in the field.

Several biomarkers have been identified in recent years. Biomarkers are proteins that can be detected in the cerebrospinal fluid and used to diagnose Alzheimer's disease. It is now clear that the typical pattern of biomarkers known as the "CSF AD profile" can be seen in the cerebrospinal fluid of patients even with very mild memory deficiencies, before these can be detected by other tests.

"The patients who had the typical changes in biomarker profile of the cerebrospinal fluid had a risk of deterioration that was 27 times higher than the control group. We could also see that all patients with mild cognitive impairment who deteriorated and developed Alzheimer's disease had these changes in the biomarker profile of their cerebrospinal fluid", says Kaj Blennow.

The scientists were also able to show a relationship between the profile of biomarkers and other typical signs of the disease, such as the presence of the gene APOE e4 and atrophy of the hippocampus, which is the part of the brain cortex that controls memory.

"Our discovery that an analysis of biomarkers in the cerebrospinal fluid can reveal Alzheimer's disease at a very early stage will have major significance if the new type of pharmaceutical that can directly slow the progression of the disease proves to have a clinical effect. It is important in this case to start treatment before the changes in the brain have become too severe", says Kaj Blennow.


Contact: Elin Lindstrom Claessen
University of Gothenburg

Related medicine news :

1. Microfluidic Systems (MFSI) is Granted a Microfluidic Cartridge Patent for DNA Separation
2. New Clinical Study Finds Masimo Rainbow SET(R) Pulse CO-Oximetry(TM) Accurate in the Noninvasive Monitoring of Fluid Status During Surgery
3. Spinal fluid proteins signal Lou Gehrigs disease
4. Chemstar Corporation Responds to Industry Demand by Developing an All-In-One Bodily Fluid Clean-Up Kit
5. Enovate IT Announces Fluid - a New Movement in Wall Arms
6. MS patients have higher spinal fluid levels of suspicious immune molecule
7. Navilyst Medical Announces Global Debut Today : Former Boston Scientific Business Units Combine to Lead Fluid Management and Vascular Access Markets
8. Boston Scientific Completes Sale of Fluid Management and Venous Access Businesses to Avista Capital Partners
9. Parkway Clinical Laboratories Expands Management Team to Support a National Growth Strategy Centered on Oral Fluid Drug Screening
10. Boston Scientific Agrees To Sell Fluid Management and Venous Access Businesses to Avista Capital Partners for $425 Million
11. Breaking Study: Masimo Pleth Variability Index (PVI) Shown Effective in Noninvasive Detection of Changes in Ventricular Preload and Fluid Volume
Post Your Comments:
Related Image:
Cerebrospinal fluid shows Alzheimer's disease deterioration much earlier
(Date:10/13/2015)... ... October 13, 2015 , ... ... of Excellence in the Life Sciences Initiative aimed at enhancing Purdue’s life sciences ... $2 billion “Ever True” capital campaign. , The investment will result in cohesive ...
(Date:10/13/2015)... West Palm Beach, FL (PRWEB) , ... October 13, 2015 , ... ... acquisition of Global Laser Vision of San Diego, California. With brands including The LASIK ... 3.3 million successful procedures, making it the nationwide leader in laser vision correction. , ...
(Date:10/13/2015)... N.J. (PRWEB) , ... October 13, 2015 , ... ... media enterprise focused on cancer patients, today announced a new partnership with the ... patients battling this rare type of non-Hodgkin’s lymphoma, their families and physicians. ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... beverage companies in the United States, today announced the release of its limited ... and new Cranberry Cocktail Agua Fresca. All feature the unique flavor combinations and ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... technology platform, ENGAGE, at HIMSS’s Patient Engagement Summit . HealthAware is a ... delivers innovative health programs and interventions via mobile devices that provide a framework ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... VEGAS , Oct. 13, 2015 VIVA ... of vascular medicine and intervention through education and research, ... annual conference,  VIVA 2015 . Sixteen trial results, featuring ... released for the first time on Monday and Tuesday, ... --> --> Since ...
(Date:10/13/2015)... , Oct. 13, 2015  Kay Elledge, ... and Fellow American College of Obstetrics and Gynecology ... evolve by establishing the Genuine Self Medical Laser ... and men.  In recognition of Breast Cancer ... special promotion for MonaLisa Touch treatments ...
(Date:10/13/2015)... PITTSBURGH , Oct. 13, 2015  Mylan N.V. (Nasdaq: ... at 5:00 p.m. ET host a conference call and webcast ... Company plc (NYSE: PRGO ; TASE) shareholders through Mylan,s ... by Mylan,s Executive Chairman Robert J. Coury , CEO ... --> --> Mylan ...
Breaking Medicine Technology: