Navigation Links
Cellular target may prove useful in treating deadly brain tumors
Date:4/3/2009

DURHAM, N.C. Duke University researchers have identified a receptor on the surface of cells that may give them another avenue of attack against glioblastoma, the most common and most deadly type of brain cancer.

The neurokinin 1 receptor (NK1R), which may be expressed in all human glioblastoma cells, may prove to be an appropriate target for therapies aimed at treating these brain tumors, according to a study led by researchers in the Duke Department of Anesthesiology and the Preston Robert Tisch Brain Tumor Center at Duke.

"There are some previously identified cellular targets for therapy which are now being investigated in clinical trials, and the findings from our research represent potential alternate or complementary targets that may help patients facing this devastating disease," said Madan Kwatra, PhD, a researcher in Duke's department of anesthesiology, and senior investigator on this study. "Patients generally die from the disease within 18 months of glioblastoma diagnosis."

The results of the study were published in the March 30, 2009 online edition of the Journal of Neurochemistry. The study was funded by the National Institutes of Health.

The researchers examined stimulation of the receptor NK1R in human glioblastoma cells growing in a dish, and found that activation of NK1R led to the activation of Akt, a cellular protein that suppresses the natural cell death process.

"In human cancers, this would translate into a proliferation of cancer cell growth," said Kwatra.

The researchers also showed that blocking NK1R activity reduced Akt activity, which then led to greater cell death.

"This finding suggests that if we are able to block NK1R activity, we may have a better shot at stalling cancer growth," Kwatra said.

A previous study showed NK1R activity in 10 out of 10 glioblastomas and nine out of 12 astrocytomas, a lower-grade malignant brain tumor.

Current thera
'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Herpes: Scientists find cellular process that fights virus
2. Liver cell adenoma or hepatocellular carcinoma?
3. American TeleCare to Present its Wireless Wide Area Network (WWAN) Option for Cellular Telehealth Connectivity at the American Telemedicine Association (ATA) Annual Meeting
4. Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference
5. CompuCyte Corporation and Program in Cellular and Molecular Medicine at Childrens Hospital Boston Announce Joint Program for Quantitative Imaging Cytometry Research Services
6. Enhanced skin cancer risk linked to defects in cellular aging controls
7. Team learns how cellular protein detects viruses and sparks immune response
8. U.S. Cellular President and CEO to Give Keynote at Employment Expo
9. Novel Photoconductive Cellular Depolarization Technology Reveals Insight Into Neuronal Growth, Guidance, and Regeneration
10. CORD:USE Cord Blood Bank Receives Prestigious Accreditation from the Foundation for the Accreditation of Cellular Therapy
11. Dormant cancer cells rely on cellular self-cannibalization to survive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 2014 Many people complain about their dependence ... each morning is put on glasses to see their clock ... individuals also may be dissatisfied with their vision even when ... may cause difficulty driving, especially at night due to glare. ... one’s golf ball, see the TV, sew or cross stitch, ...
(Date:7/29/2014)... Alan Mozes HealthDay Reporter ... autism patients with just a single dose of the hormone ... emotions, Japanese researchers report. Known as the "love hormone," ... bonding between lovers, and between mothers and their children. ... key area of the brain that has long been associated ...
(Date:7/29/2014)... During his 37 years in dental practice, Dr. Arthur ... a steady stream of college students shadow him in order ... on to dental school and some are now practicing dentistry ... college students find success. , For students interested in applying ... to see a realistic view of what goes on in ...
(Date:7/29/2014)... headache sufferers to record the severity and regularity of ... Griffith research study. , A new approach to the ... with their triggers and is being led by Professor ... Health program. , He has developed an approach designed ... their headaches called Learning to Cope with Triggers (LCT). ...
(Date:7/29/2014)... Palm Beach, Florida (PRWEB) July 29, 2014 ... new scholarship for law students this week. The scholarship will ... of abused children and their families. , Steinger, Iscoe and ... past abuse, and want tomorrow’s attorneys to do the same. ... States each year according to the nonprofit Childhelp ...
Breaking Medicine News(10 mins):Health News:Cataract Surgery: New Technology for Reduced Dependence on Glasses 2Health News:'Love Hormone' Oxytocin May Help Some With Autism 2Health News:'Love Hormone' Oxytocin May Help Some With Autism 3Health News:Arthur Bruce Dental Helps College Students 2Health News:Steinger, Iscoe & Greene Offers Child Advocate Scholarship 2
... Prepare Nurses for the Future of Healthcare , ... ... meet the growing demand for highly qualified nurse administrators, nurse leaders ... to launch its fully online Master of Science in Nursing (M.S.N.) ...
... that 20 percent of women experience excessive or ... lives, particularly as they approach menopause. A new, ... preserves the uterus, while decreasing menstrual bleeding and ... in the January issue of Obstetrics and ...
... 5 One in ten people will suffer from a,seizure ... with epilepsy.,Medication will help approximately two-thirds of the people with ... other alternatives. , "Epilepsy ended my ... Marquette University . "I would have seizures in front ...
... Chilcott Limited (Nasdaq: WCRX ) announced today ... CEOs Unscripted Conference on Thursday, January 8, 2009 at ... be Roger Boissonneault, President and Chief Executive Officer and ... Chilcott,s presentation will be webcast live for all interested ...
... the disease falls short, study finds, , , MONDAY, Jan. 5 ... living to older ages, thanks to medical advances. But the ... Americans may not be ready for the additional challenges that ... spend appropriate time to think of a way to successfully ...
... Resolving to eat more fish, which contain,long-chain omega-3 ... especially for those with heart disease, according to current,research. ... Newsletter electronic,publications summarize findings that seafood omega-3s protect the ... An Italian study with nearly 7,000 ...
Cached Medicine News:Health News:Benedictine University Launches New Online Program, Master of Science in Nursing 2Health News:Benedictine University Launches New Online Program, Master of Science in Nursing 3Health News:Mayo researchers offer new insight into effectiveness of procedure to stop heavy menstrual bleeding 2Health News:Mayo researchers offer new insight into effectiveness of procedure to stop heavy menstrual bleeding 3Health News:Ending Epileptic Seizures 2Health News:Diabetes Epidemic Now Poses Challenges for Nursing Homes 2Health News:Diabetes Epidemic Now Poses Challenges for Nursing Homes 3Health News:Eating More Fish a Wise New Year Resolution, Studies Show 2
(Date:7/29/2014)... COLORADO SPRINGS, Colo. , July 29, 2014 /PRNewswire-USNewswire/ ... remote-controlled catheter (MARC) which could allow physicians to see ... stroke may hold promise, according to study authors who ... Surgery (SNIS) 11 th Annual Meeting in ... findings stand to advance the field of neurointervention, a ...
(Date:7/29/2014)... , July 29, 2014 /PRNewswire-iReach/ -- MHG ... provider, has launched its Medical Equipment and ...  These services are tailored to the cruise industry,s ... prompted industry operators to propose that they should ... Medical,s new program is intended to create standardized ...
(Date:7/29/2014)... 29, 2014  Neurocrine Biosciences, Inc. (Nasdaq: ... its second quarter 2014 financial results after the Nasdaq ... then host a live conference call and webcast to ... Thursday morning, August 7, 2014 at 8:00 a.m. Eastern ... access the live conference call by dialing 866-952-1907 (US) ...
Breaking Medicine Technology:New Technology May Improve Visualization Of The Brain During Stroke Treatment 2New Technology May Improve Visualization Of The Brain During Stroke Treatment 3MHG Medical Management Services Aims to Change Cruise Industry Standard With New Equipment Maintenance Program 2Neurocrine Biosciences Announces Conference Call And Webcast To Report Second Quarter 2014 Financial Results 2
Quantitative determination of cortisol levels in serum and urine. Cross-reactivity with dexamethasone: 0.2% (suppression test).Time to first result: 30 minutes....
... IMMULITE 2000 assays are ... the IMMULITE 2000, a ... immunoassay analyzer. IMMULITE 2000 ... centralization, and a rapidly ...
... from KUBTEC is a dual capability system with ... representation of the specimen under test. While the ... images, the micro focus source also allows the ... standard 2D images. The 50 mm x 50 ...
... Provides Microsoft Windows-based urodynamics for fast, ... where logic, efficiency and economy are ... designed with modularity and expandability in ... diagnostic tools and establish a complete ...
Medicine Products: