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Cellular pathway linked to diabetes, heart disease
Date:4/19/2012

tissue during obesity.

"In this study, we used 'knockout' mouse models to test this theory," he says. "Deleting the HDAC9 gene completely prevented mice from developing obesity-related diseases during chronic high-fat feeding. These results mean the discovery of a potential molecular culprit in obesity-related disease development."

Chatterjee says emerging evidence from his laboratory indicates that unhealthy dietary habits over a long period of time promote specific changes in a human's epigenetic structuremeaning changes in the gene structure that influences its functionto switch HDAC9 expression to a higher level.

"This switch paves the way for development of a chronic disease state, despite subsequent dietary intervention," he says. "We are currently focusing our attention to design drugs to reverse such epigenetic changes to bring HDAC9 expression down and restore normal fat cell function in obese individuals, representing a novel treatment strategy for obesity-related disease conditions."


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Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

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