Navigation Links
Cellular pathway linked to diabetes, heart disease
Date:4/19/2012

CINCINNATICardiac researchers at the University of Cincinnati (UC) have found that a certain cellular pathway is linked to obesity-related disorders, like diabetes, heart disease and fatty liver disease.

These findings, being presented at the American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) 2012 Scientific Sessions in Chicago, April 19, 2012, could lead to a potential molecular target for metabolic diseases in humans.

Building on previous research, Tapan Chatterjee, PhD, and researchers in the division of cardiovascular diseases at UC found that genetically "deleting" the enzyme histone deacetylase 9 (HDAC9) completely protected mice against the health consequences of high-fat feeding, like elevated blood sugar, cholesterol levels and fatty liver disease.

Chatterjee says HDAC9 has been found to lead to obesity-induced body fat dysfunction.

"Failure of fat cells to differentiate and properly store excess calories in obesity is associated with adipose tissue (fat) inflammation, fatty liver disease, insulin resistance, diabetes and increased cardiovascular diseases," he says. "We know that dysfunctional fat tissue is the underlying culprit in obesity-related diseases.

"Caloric intake promotes HDAC9 down-regulation to allow the conversion of precursor fat cells to 'functional' fat cells, capable of efficiently storing excess calories for future use and also maintaining whole-body lipid and glucose stability," Chatterjee continues. "Unfortunately, during chronic over-feeding, the HDAC9 level is up-regulated in fat tissue, thereby blocking the conversion which leads to adipose tissue dysfunction and the onset of diseases such as diabetes, liver disease, high blood pressure and heart diseasethe nation's No. 1 killer."

Chatterjee says that in previous studies, researchers found that elevated HDAC9 expression in fat cells was the underlying molecular culprit for dysfunctional fat tissue during obesity.

"In this study, we used 'knockout' mouse models to test this theory," he says. "Deleting the HDAC9 gene completely prevented mice from developing obesity-related diseases during chronic high-fat feeding. These results mean the discovery of a potential molecular culprit in obesity-related disease development."

Chatterjee says emerging evidence from his laboratory indicates that unhealthy dietary habits over a long period of time promote specific changes in a human's epigenetic structuremeaning changes in the gene structure that influences its functionto switch HDAC9 expression to a higher level.

"This switch paves the way for development of a chronic disease state, despite subsequent dietary intervention," he says. "We are currently focusing our attention to design drugs to reverse such epigenetic changes to bring HDAC9 expression down and restore normal fat cell function in obese individuals, representing a novel treatment strategy for obesity-related disease conditions."


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Natural method for clearing cellular debris provides new targets for lupus treatment
2. Health benefits of exercise may depend on cellular degradation, UT Southwestern researchers report
3. Cancer drug cisplatin found to bind like glue in cellular RNA
4. Researchers discover new way to form extracellular vesicles
5. Research in cellular memory
6. European studies on risks of hepatocellular carcinoma
7. New insight into the cellular defects in Huntingtons disease
8. Vacuum-like device makes cellular exploration easier
9. Scripps Research scientists define cellular pathway essential to removing damaged mitochondria
10. High-resolution imaging technology reveals cellular details of coronary arteries
11. Cellular origin of deadly brain cancer is identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... ... According to recent statistics, there are nearly half a million physical ... Each physical therapy professional and every clinic has a duty to perform at the ... a competitive industry is also essential. The solution that many physical therapy leaders turn ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... FDAI, DAHC, CDC, has joined the Fire Door Solutions’ team. Keith will ... fire door and frame in-field re-labeling. He will be instrumental in developing ...
(Date:5/31/2016)... ... ... More than 80 representatives of the Hepatitis B Foundation , Hepatitis ... an event on National Hepatitis Testing Day outside of Philadelphia City Hall to raise ... of liver cancer. , Foundation leaders and the citywide coalition they created, Hep B ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... Healthconnect’s (Healthconnect) regional health information exchange, which enables physicians at SJMC’s two hospital ... patients from other participating organizations in the exchange. SJMC’s membership in the health ...
(Date:5/31/2016)... Beach, Florida (PRWEB) , ... May 31, 2016 ... ... to Jay Butch of CertainTeed Corporation, he knew it was something that contractors ... as state-of-the-art and cutting-edge as it gets,” says Butch, CertainTeed’s Director of Contractor ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... -- On 28 May, 194 Member States made ... the 69 th World Health Assembly, governments unanimously voted ... the greatest global commitment in viral hepatitis to date. ... and C by 2030 and includes a set of prevention ... by 65% and increase treatment to 80%, saving 7.1 million ...
(Date:5/30/2016)... 2016 LifeScienceIndustryResearch.com adds "Ulcerative ... report with comprehensive information on the therapeutic development ... various stages, therapeutics assessment by drug target, mechanism ... molecule type, along with latest updates, and featured ... players involved in the therapeutic development for Ulcerative ...
(Date:5/27/2016)... -- A new study highlights the necessity of health literacy within the technology advancement of ... of Radiology , a majority of oncology patients undergo imaging screenings without understanding the ... ... ... Medical Diagnostic Imaging Ampronix ...
Breaking Medicine Technology: