Navigation Links
Cells talk more in areas Alzheimer's hits first, boosting plaque component
Date:5/2/2011

Higher levels of cell chatter boost amyloid beta in the brain regions that Alzheimer's hits first, researchers at Washington University School of Medicine in St. Louis report. Amyloid beta is the main ingredient of the plaque lesions that are a hallmark of Alzheimer's.

These brain regions belong to a network that is more active when the brain is at rest. The discovery that cells in these regions communicate with each other more often than cells in other parts of the brain may help explain why these areas are frequently among the first to develop plaques, according to the researchers.

Working with mice genetically engineered to develop Alzheimer's type-brain changes, scientists reduced the size and number of plaques by decreasing brain cell activity in certain regions.

The results, appearing May 1 in Nature Neuroscience, are the latest to hint at a resolution to lines of evidence that have suggested busier brain cells can both contribute to and prevent Alzheimer's. According to a new theory, which brain cells are kept busy may make all the difference.

"Engaging the brain in tasks like reading, socializing or studying may be helpful because they reduce activity in susceptible regions and increase activity in regions that seem to be less vulnerable to Alzheimer's plaque deposition," says David M. Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology. "I suspect that sleep deprivation and increased stress, which may affect Alzheimer's risk, may also increase activity levels in these vulnerable regions."

The susceptible regions of the brain highlighted in the new study belong to the default mode network, a group of brain regions that become more active when the brain is not engaged in a cognitively demanding task. Co-author Marcus Raichle, MD, professor of neurology, of radiology and of neurobiology, was among the first to describe the default mode network.

<
'/>"/>
Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
2. New study suggests stem cells sabotage their own DNA to produce new tissues
3. Attacking cancer cells with hydrogel nanoparticles
4. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
5. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
6. New tool illuminates connections between stem cells and cancer
7. Bitter melon extract attacks breast cancer cells
8. Heart Stem Cells Move Closer to Human Treatments
9. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
10. Cells of aggressive leukemia hijack normal protein to grow
11. Periodontal pathogens enhance HIV-1 promoter activation in T cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cells talk more in areas Alzheimer's hits first, boosting plaque component
(Date:10/31/2014)... Chico, CA. (PRWEB) October 31, 2014 ... best known for its small scale BioPro™ biodiesel ... equipment that will further improve the performance and ... , The GL95/MC12/BD380 trio will recover ... is mixed in with the glycerin by-product produced ...
(Date:10/31/2014)... Research Center for Healthy Neighborhoods (PRCHN) at Case ... key player in nearly $13.32 million in federal ... Ohio. , The Centers for Disease Control and ... million over five years. The funds will support ... disseminating individual, environmental, and policy interventions that prevent ...
(Date:10/31/2014)... Colorado (PRWEB) October 31, 2014 The Memory ... was created by Alexander Lynch, whose father suffered from Alzheimer's ... a dramatic moment, caused by his father's disease. His father ... That was the crucial moment when the author of this ... his dad. , The Memory Healer program is based ...
(Date:10/31/2014)... 2014 Monica Williams-Murphy MD , ... too well the chaos that can occur for people ... vast majority of Americans who come into the emergency ... completely unprepared for the moment and so are their ... serve as a catalyst for a family to get ...
(Date:10/31/2014)... Summit, Missouri (PRWEB) October 31, 2014 ... the country about families narrowly escaping carbon monoxide poisoning ... season) looms just weeks away, one family-owned, Missouri-based heating ... straightforward approach to making sure families start the home ... are safe and secure. , Beginning Nov. 1, ...
Breaking Medicine News(10 mins):Health News:Springboard Biodiesel Announces Release of New and Unique Methanol Recovery and Glycerin Treatment Equipment 2Health News:Springboard Biodiesel Announces Release of New and Unique Methanol Recovery and Glycerin Treatment Equipment 3Health News:Case Western Reserve, Cuyahoga County, YMCA of greater Cleveland: Public health grants 2Health News:Case Western Reserve, Cuyahoga County, YMCA of greater Cleveland: Public health grants 3Health News:"Memory Healer" Review Reveals a New Natural Remedy Guide for Managing Memory Loss 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 2Health News:This Thanksgiving or Christmas Family Gathering, Use The New App ListStuffFast to Start "The Conversation" With a Parent That Has No Plan For End-of-Life 3Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 3
... at the Imperial College London it was found that lab ... , It was believed that early exposure to ... lab workers who frequently handled research rodents had fewer allergic ... to be protective against eczema allergy. The study results are ...
... a stroke, caused either by a blocked or burst blood vessel ... die. ,That's the bad news. ,And the good news! ... problems that cause many strokes — before a stroke ever happens. ... the skull. ,New technologies, delivered to the brain via ...
... who is now 42 years old has been slightly unconscious and ... His nerves were completely sheared in a car crash and he ... others by means of grunts and nods. But now his speech ... the tiny nerve connections in his brain slowly started to rewire. ...
... conducted by the Korean scientists from the Korea Research Institute of ... that the research team has found a human gene that aids ... The researchers were very happy about the discovery and said that ... cancers. ,The study was mainly conducted on mice and ...
... Haryana Government has decided to start a two year ... in Panchakarma at Shri Krishna Government// Ayurvedic College at ... diploma courses has already been formulated and these courses ... state Health Minister Kartar Devi told reporters here., ...
... to be far from the goal of any reversal of the ... in cases of drug abuse in all of Europe//. The statistics ... abuse category and a rank 3 in cocaine and ecstasy abuse. ... abuse. ,As per the drug policy of the government, ...
Cached Medicine News:Health News:Brain Surgery Without the Surgery? 2Health News:Brain Surgery Without the Surgery? 3Health News:Brain Surgery Without the Surgery? 4Health News:Brain Surgery Without the Surgery? 5Health News:Brain Surgery Without the Surgery? 6
(Date:10/30/2014)... Atlantic Canadians will save an estimated $560-million through an ... provinces and territories and the generic pharmaceutical industry, ... Pharmaceutical Association (CGPA), said today. Mr. ... Summit on Healthcare and Drug Cost Sustainability in ... the Public Policy Forum and sponsored by the four ...
(Date:10/30/2014)... 30, 2014   NxStage® Kidney Care, Inc ., a ... is proud to host the grand opening ceremony of its ... W. 16 th Street on November 20, 2014 from ... trained medical staff who are committed to providing patients with ... benefits made possible through more flexible dialysis treatment options.   ...
(Date:10/30/2014)... 30, 2014 Boston Scientific Corporation (NYSE: ... 2014 Credit Suisse Annual Healthcare Conference on Tuesday, November ... Dan Brennan , executive vice president and chief ... beginning at approximately 8:00 a.m. PT followed by a ... of the presentation and question and answer session will ...
Breaking Medicine Technology:Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3Grand Opening of NxStage Kidney Care Oak Brook IL Center 2Grand Opening of NxStage Kidney Care Oak Brook IL Center 3Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2
... WORTH, Texas, March 3, 2011 A new report ... residents of 12 counties in East Texas are breathing a ... conducted by the health science center,s Center for Professional ... chronic obstructive pulmonary disease (COPD).  The report shows ...
... March 3, 2011 AORN Works , a ... announced that its market research and surgical insights division ... (Logo: http://photos.prnewswire.com/prnh/20101001/DC75398LOGO ) ... attitudes of perioperative professionals who are the end users ...
Cached Medicine Technology:Educational Efforts Reduce COPD Costs by $3.4 Million in East Texas Study 2Educational Efforts Reduce COPD Costs by $3.4 Million in East Texas Study 3Educational Efforts Reduce COPD Costs by $3.4 Million in East Texas Study 4Advanced Market Research for Medical Device Manufacturers 2
... SAFE-T-FILL Capillary Blood Collection Tubes are 100% ... a wide range of applications, the Capillary ... tube, attached cap and a micro tube.,The ... the blood into the micro tube thereby ...
... Scientifics SAFE-T-FILL Capillary Blood Collection Tubes are ... for a wide range of applications, the ... capillary tube, attached cap and a micro ... draw the blood into the micro tube ...
... The Bio-Rad Mumps IgG test is an ... Test results are obtained after a 90-minute incubation. ... index values, permitting uniformity of reporting. The ... qualitative and semi-quantitative detection of human IgG antibodies ...
... Bio-Rad Measles IgG test is an enzyme immunoassay ... are obtained after a 90-minute incubation. The ... permitting uniformity of results. The Bio-Rad Measles ... semi-quantitative detection of human IgG antibodies to measles ...
Medicine Products: