Navigation Links
Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine
Date:4/16/2014

HAMPTON, NJ (April 16, 2014): Celldex Therapeutics, Inc. (NASDAQ: CLDX) announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine (Vol 6 Issue 232). The data demonstrate robust antibody and T cell responses and evidence of clinical benefit in patients with very advanced cancers and suggest that CDX-1401 may predispose patients to better outcomes on subsequent therapy with checkpoint inhibitors. CDX-1401 is an off-the-shelf vaccine consisting of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 linked to the NY-ESO-1 tumor antigen. The vaccine is designed to activate the patient's immune system against cancers that express the tumor marker NY-ESO-1. While the function of NY-ESO-1 continues to be explored, references in the literature suggest that its expression might reflect the acquisition of properties that cancers find useful, such as immortality, self-renewal, migratory ability and the capacity to invade.

The Phase 1 study of CDX-1401 is the first clinical study to demonstrate that an off-the-shelf vaccine that targets dendritic cells in vivo through DEC-205 can safely lead to robust humoral and cellular immunityovercoming a significant challenge in the development of protein based vaccines. Targeting protein antigens to the DEC-205 receptor on dendritic cells was pioneered by the late Ralph Steinman, MD, a member of Celldex's Scientific Advisory Board. Dr. Steinman received the 2011 Nobel Prize in Physiology or Medicine for his discovery of the dendritic cell and its role in adaptive immunity. This now-proven ability to target proteins, like NY-ESO-1, to dendritic cells to generate potent immune responses specific to these proteins represents a promising approach for the next generation of vaccines against pathogens and cancer.

"CDX-1401 offers a novel, well-tolerated and practical a
'/>"/>

Contact: Sarah Cavanaugh
scavanaugh@celldex.com
508-864-8337
Celldex Therapeutics
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. ALS patients differ on treatment choices in later phases of disease
2. Reach2HD, a Phase II study in Huntingtons disease, launched
3. Analysis of KRYSTEXXA phase III data demonstrates improved health-related quality of life and physical function in refractory chronic gout patients
4. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
5. IDRI and Medicago announce authorization to initiate a Phase 1 clinical trial for an H5N1 vaccine
6. COPD Foundation and BWH announces second phase of groundbreaking COPDGene project
7. JDRF announces winners of first phase of Agnes Varis Glucose-Responsive Insulin Challenge
8. Positive results from Phase 1/2 stem cell trial reported
9. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
10. Teva to present new Phase III data for QNASL® Nasal Aerosol at the 2012 ACAAI Meeting
11. Edison Pharmaceuticals announces initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... FL (PRWEB) April 26, 2015 A ... pieces of medical equipment from hospitals, surgery centers and ... of equipment will be sold including radiology, surgery, endoscopy, ... live auction will take place Tuesday, April 28th starting ... Lauderdale warehouse located at 5025 North Hiatus Rd., Sunrise, ...
(Date:4/26/2015)... New York (PRWEB) April 26, 2015 ... popular events of the season and will include a ... like purses, totes, collectibles, herbal soaps and incense, chimes, ... While browsing this year’s exciting and unique collection of ... their afternoon with Jim Martocci and the Jimmie Jazz ...
(Date:4/26/2015)... 26, 2015 Forbes Living is ... is one which is synonymous with clean beaches, sparkling office ... education are major economic influencers in the city on the ... talk show are pleased to announce the show will be ... at 3:00 PM PDT. Tune in to find out what ...
(Date:4/26/2015)... MidSouth Pain Treatment Center has ... Pain Treatment Center is a comprehensive pain management center ... Jackson, two ambulatory surgery centers in Germantown and Southaven, ... locations. , Dr. Michael Steuer , founder of ... help people, and when I discovered that I could ...
(Date:4/25/2015)... 2015 Diversified Communications has announced ... event. The Integrative Healthcare Symposium Canada, as it’s ... at the Sheraton Parkway Toronto North in Ontario. ... of the most anticipated events of the year ... program. The event aims to gather multi-disciplined practitioners ...
Breaking Medicine News(10 mins):Health News:Centurion Service Group to Auction off 1,200 Lots of Medical Equipment 2Health News:It’s Coming! The 5th Annual Tulip Festival & Mother’s Day Celebration at Honor's Haven Resort & Spa! 2Health News:Forbes Living TV Will Air in San Diego, California 2Health News:Growing Pains for MidSouth Pain Treatment Center 2Health News:Integrative Healthcare Event launching in Canada 2
... 5 in the February 2008 edition (Volume 6, Issue ... team found that the hypertension drugs diltiazem and verapamil ... with the conditions Gaucher disease, -mannosidosis, and type IIIA ... reprogramming the innate protein homeostasis machinery of the cell ...
... WASHINGTON, Feb. 4 "Congress must reject,President Bush,s Fiscal ... needs of the over 1.1 million people living with ... Director of The AIDS,Institute. "Most of the people who ... are very poor and from minority communities.,As the richest ...
... largest of its kind , , MONDAY, Feb. 4 (HealthDay News) ... link between the measles, mumps and rubella (MMR) vaccine and ... theirs was the third and largest study that has looked ... has failed to find one. , "I think it,s fabulous ...
... Gilbert Hospital is,celebrating its second anniversary. Gilbert,s first ... more than 93,000 patients and has a,staff exceeding 350. ... room wait times of less than 31 minutes, Gilbert,Hospital ... this pledge,more than 98.5 percent of the time. "There ...
... Feb. 4 - President George W.,Bush today submitted ... 2009.,In response Bruce Roberts, RPh, executive vice president ... issued the following,statement:, "President Bush,s efforts to ... health care, and even more specifically the Medicare,and ...
... a consulting firm,dedicated exclusively to improving the pharmacy ... the recent,introduction of the ARMSRx E-Audit, their upgraded ... often overlooked piece of the prescription,benefits package. The ... of opportunities in which errors can occur. Fraud, ...
Cached Medicine News:Health News:Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells 2Health News:Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells 3Health News:Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells 4Health News:President's FY09 Budget - A Disaster for Domestic AIDS: Congress Must Fund Critical Healthcare Priorities 2Health News:President's FY09 Budget - A Disaster for Domestic AIDS: Congress Must Fund Critical Healthcare Priorities 3Health News:Another Study Finds No Link Between MMR Vaccine and Autism 2Health News:Another Study Finds No Link Between MMR Vaccine and Autism 3Health News:Gilbert Hospital Turns Two 2Health News:NCPA Statement in Response to President Bush's FY 2009 Budget Proposal 2Health News:ARMSRx Tackles the New Rx Addiction -- Pharmacy Benefit Audits 2
(Date:4/24/2015)... N.C. , April 24, 2015  New ... ability of consumers to educate themselves about products ... the tools and techniques available to market researchers ... the changing consumer marketplace, it,s imperative that organizations ... to better identify market opportunities, niches and growth ...
(Date:4/24/2015)... MARLBOROUGH, Mass. , April 24, 2015 Boston ... in the Deutsche Bank 40 th Annual Healthcare Conference ... Dan Brennan , executive vice president and chief ... Relations, will participate in a 35-minute question and answer session ... a.m. ET. A live webcast of the presentation ...
(Date:4/24/2015)... , April 24, 2015  Novartis Pharmaceuticals Corporation (NPC) ... second year in a row on the annual DiversityInc Top ... its 2015 Top 50 Companies for Diversity on April 23 ... . NPC also ranked second on the DiversityInc Top ... 10 Companies for Employee Resource Groups list. ...
Breaking Medicine Technology:Pharmaceutical Industry Using New Technologies to Adjust Their Marketing and Research Approaches for Consumers 2Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4
... 2011 /PRNewswire-Asia-FirstCall/ -- American Oriental Bioengineering, Inc. (NYSE: ... company dedicated to improving health through the development, manufacture ... over the counter ("OTC") products, today announced that it ... financial results on Monday, March 14, 2011, after the ...
... China, March 4, 2011 /PRNewswire-Asia-FirstCall/ -- ... WKBT ) ("Weikang" or the "Company"), a ... (TCM), Western prescription and OTC pharmaceuticals and other health ... today announced that the Company will be presenting at ...
Cached Medicine Technology:American Oriental Bioengineering to Announce Fourth Quarter and Full Year 2010 Financial Results on March 14, 2011 2Weikang Bio-Technology to Present at Rodman & Renshaw Annual China Investment Conference 2
... Vitamin D kit is an enzymeimmunoassay for ... hydroxylated metabolites in serum or plasma. Calibrators, ... labelled 25-OH D. The diluted samples are ... with a highly specific sheep 25-OH D ...
... for the control of glucose metabolism. It ... of Langerhans as the precursor, proinsulin, which is ... are secreted in equimolar amounts into the portal ... of two polypeptide chains, the A-chain and B-chain ...
... is an integral part of the enzymatic ... II as well as the degradation of ... ACE is primarily located in endothelial cells. ... parameter for sarcoidosis and myocardial infarction but ...
... Retinol binding Proetin (RBP) is small (21kD) ... complex with pre-albumin in blood but loses ... been deliverd to the target cells. The ... the glomerulus and catabolized in the,renal tubules ...
Medicine Products: