Navigation Links
Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine
Date:4/16/2014

HAMPTON, NJ (April 16, 2014): Celldex Therapeutics, Inc. (NASDAQ: CLDX) announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine (Vol 6 Issue 232). The data demonstrate robust antibody and T cell responses and evidence of clinical benefit in patients with very advanced cancers and suggest that CDX-1401 may predispose patients to better outcomes on subsequent therapy with checkpoint inhibitors. CDX-1401 is an off-the-shelf vaccine consisting of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 linked to the NY-ESO-1 tumor antigen. The vaccine is designed to activate the patient's immune system against cancers that express the tumor marker NY-ESO-1. While the function of NY-ESO-1 continues to be explored, references in the literature suggest that its expression might reflect the acquisition of properties that cancers find useful, such as immortality, self-renewal, migratory ability and the capacity to invade.

The Phase 1 study of CDX-1401 is the first clinical study to demonstrate that an off-the-shelf vaccine that targets dendritic cells in vivo through DEC-205 can safely lead to robust humoral and cellular immunityovercoming a significant challenge in the development of protein based vaccines. Targeting protein antigens to the DEC-205 receptor on dendritic cells was pioneered by the late Ralph Steinman, MD, a member of Celldex's Scientific Advisory Board. Dr. Steinman received the 2011 Nobel Prize in Physiology or Medicine for his discovery of the dendritic cell and its role in adaptive immunity. This now-proven ability to target proteins, like NY-ESO-1, to dendritic cells to generate potent immune responses specific to these proteins represents a promising approach for the next generation of vaccines against pathogens and cancer.

"CDX-1401 offers a novel, well-tolerated and practical a
'/>"/>

Contact: Sarah Cavanaugh
scavanaugh@celldex.com
508-864-8337
Celldex Therapeutics
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. ALS patients differ on treatment choices in later phases of disease
2. Reach2HD, a Phase II study in Huntingtons disease, launched
3. Analysis of KRYSTEXXA phase III data demonstrates improved health-related quality of life and physical function in refractory chronic gout patients
4. Phase III trial of dapivirine ring begins in Africa: New HIV prevention approach for women
5. IDRI and Medicago announce authorization to initiate a Phase 1 clinical trial for an H5N1 vaccine
6. COPD Foundation and BWH announces second phase of groundbreaking COPDGene project
7. JDRF announces winners of first phase of Agnes Varis Glucose-Responsive Insulin Challenge
8. Positive results from Phase 1/2 stem cell trial reported
9. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
10. Teva to present new Phase III data for QNASL® Nasal Aerosol at the 2012 ACAAI Meeting
11. Edison Pharmaceuticals announces initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... Purity Products®, a leading direct to ... of their revolutionary new weight loss product, MuffinStop™. ... placebo-controlled clinical studies to be effective in reducing ... is a combination of two traditionally used botanical ... to create one of the most innovative weight ...
(Date:3/28/2015)... LTW Cyber is an innovation hub ... the purpose of addressing the needs of the global ... own opportunities to grow while seeking collaborative opportunities with ... , Ventures in LTW Cyber focus on secure application ... identifying vulnerabilities and analyzing open source. As the ...
(Date:3/27/2015)... Island, NY (PRWEB) March 27, 2015 ... cancer-focused training and business criteria for the spa and ... services to clients who have experienced or are living ... the global Spafinder Wellness 365® Network, will be identified ... and recognized as a provider of safe, therapeutic services ...
(Date:3/27/2015)... Florida Hospital is excited to continue its partnership with ... provider for the 2015 and 2016 season. As the Storm’s ... an athletic trainer for the team throughout each season. Tonight, ... the Cleveland Gladiators at Amalie Arena; the game starts at ... us as it gives us the opportunity, to provide health ...
(Date:3/27/2015)... Texas (PRWEB) March 27, 2015 First ... 7am today. The new facility is located 12665 W Lake ... “As a resident of Summerwood, I look forward to delivering ... said Dr. Sowell, Facility Medical Director of First Choice Emergency ... Choice Emergency Room made a donation to Summer Creek High ...
Breaking Medicine News(10 mins):Health News:Purity Products Releases Revolutionary New Weight Loss Product, MuffinStop™ 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 4Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2
... patients, according to a recent study, are increasingly turning ... In this context physicians need to be aware of ... patients to the most reliable, accurate and updated information. ... Cancer Center in Philadelphia echoed these ideas at the ...
... Dr. Balakrishna Ganapat Rao Matapurkar, from Maulana Azad Medical ... winning the first patent on organ regeneration from the ... / repairing organs in human beings. ,A few ... patent on this technique. Dr. Matapurkar was able ...
... has come out with a damning disclosure that half the ... Tobacco Day 2001," World Health Organization chief Gro Harlem Brundtland ... because most governments still allowed smoking in public places. She ... no safe permissible levels of second hand smoke. ,"Far ...
... Pfizer on the Indian front has run into rough ... subsidiary Parke-Davis (India). A local court in Hyderabad ... the city. ,The vacation court of the Ranga ... and machinery of Parke-Davis (India) following a petition filed ...
... forward by Brazil, at the annual assembly of the ... breast-feeding for the first six months in all infants. ... on Wednesday after 2 hours of debate where many ... for breast-feeding. ,Nestle, a maker of infant formula ...
... reproductive scientists plan to launch a human cloning clinic, ... 18 months, according to a US infertility specialist, Dr. ... Univeristy of Kentucky, is not medically qualified but holds ... and director of two USD infertility clinics, the Kentucky ...
Cached Medicine News:Health News:Scientists plan human cloning clinic in the United States 2
(Date:3/27/2015)... -- Concord Medical Services Holdings Limited ("Concord Medical" ... leading specialty hospital management solution provider and operator ... imaging centers in China , ... under which Concord Medical Services (International) Pte Ltd, ... to acquire the Fortis Surgical Hospital from Fortis ...
(Date:3/26/2015)... -- The Burzynski Research Institute, Inc. (BRI) announced today that ... Department of Surgery at Kurume University Medical Center ... published. The study, a randomized non-blinded phase 2 ... adjuvant therapy with and without Antineoplastons A10/AS2-1 Injections ... A total of 65 patients, with histologically ...
(Date:3/26/2015)... Calif. , March 26, 2015 Huntington ... Gabriel Valley to perform transcatheter aortic valve replacement (TAVR), ... procedure is a revolutionary new way to replace an ... of a heart lung machine. The procedure ... team led by Azhil ( Alex) Durairaj , MD, ...
Breaking Medicine Technology:Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2
... , EXTON, Pa., Nov. 23 ... LaunchTrends (TM): Feraheme report, the second ... AMAG,s new IV iron product, Feraheme, through the first six months ... information from 50 unique Nephrologists and qualitative information from a subset ...
... , FORT WORTH, Texas, Nov. 23 ... of specialty medical products, announced that it has filed it Q3 2009 ... the developments during the 2009 calendar year. , Q3 2009 sales ... , Shareholder equity as of the Q3 2009 increased to $3,327,892 ...
Cached Medicine Technology:Reported Use of AMAG's Feraheme (ferumoxytol) Continues To Be Low, But a Number of Nephrologists Are 'On the Verge' of Use 2Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update 2Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update 3Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update 4Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update 5Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update 6
... automated 100-position ESR analyzer designed for laboratories ... instrument accurately and precisely measures the sedimentation ... ESR-Vacuum Tubes. Results are measured in millimeters ... available in 30 minutes. The ESR-100 features ...
... Sysmex CA-1500 enhances productivity in the laboratory ... three detection methods clotting, chromogenic and ... and precise test results every time. ... options and random access, the CA-1500 will ...
... Qwik-Let Elite has become one of ... This popularity is due to the ... in the design and function of ... device is priced for far less ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,410-0) or contact custom...
Medicine Products: