Navigation Links
Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
Date:9/20/2007

Irvine, Calif., Sept. 20, 2007 Defects on cell-surface sugars may promote the short-term inflammation and long-term neurodegeneration that occurs in the central nervous system of multiple sclerosis patients, according to University of California, Irvine researchers.

The findings also suggest that a dietary supplement similar to glucosamine may be useful as an oral therapy to correct these defects and to treat both the short-term and the long-term symptoms of the disease. Study results appear on the online version of the Journal of Biological Chemistry.

The findings raise the possibility that these may both be treated by metabolic therapy, said Dr. Michael Demetriou, an assistant professor of neurology, and microbiology and molecular genetics. This is particularly important, as therapies are not currently available to treat neurodegeneration in MS.

In tests on mice, Demetriou found that genetic deficiencies in a process called protein glycosylation led to a spontaneous disease very similar to MS, including paralysis associated with inflammatory damage to the protective myelin coating on nerve cells and degeneration of axons and neurons. Protein glycosylation refers to the addition of specific sugars to proteins; virtually all cell-surface and secreted proteins have complex sugars attached to them.

MS is a two-stage disease, with initial attacks of inflammatory demyelination, which damages myelin, followed approximately 10 years later by a slow, progressive neurdegenerative phase marked by loss of axons and nerve cells.

The irreversible damage to the central nervous system induced by neurodegeneration in MS leads to long term disability, including paralysis, incoordination, dementia and pain, and is not targeted by currently available therapies.

Demetrious findings provide the first genetic model of MS in which both inflammatory demyelination and neurodegeneration arise from defects in a single biologi
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Increase in sugar...decrease in brain function!!!
2. Testing for blood sugar levels made easier
3. Blood Sugar Linked to Deaths in ICU
4. Sugar Cravings
5. Effective Control Of Blood Sugar Levels
6. Sugar - Sweetened Drinks Found To Increase Risk of Diabetes
7. Diabetics Can Now Be Able To Control Both Blood Sugar And Their Weight
8. Elevated Blood Sugar Levels A Risk Factor Of Heart Disease
9. Better Control Of Sugar Levels
10. Link Between High Blood Sugar And Behavioral Changes
11. Herb Found To Be Effective In Controlling Blood Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Men who show signs of chronic inflammation in non-cancerous ... actually having prostate cancer than those with no inflammation, ... researchers from the Johns Hopkins Kimmel Cancer Center. , ... stronger for men with so-called high-grade prostate cancer ... indicating the presence of the most aggressive and ...
(Date:4/17/2014)... One of the most popular vaccine brands for children ... may be overlooking some cost factors when choosing vaccines, ... expensive option, according to a new study by University ... administer can be driven by numerous factors," says Sheldon ... professor of computer science and of mathematics at the ...
(Date:4/17/2014)... at the University of California, San Diego School of ... who have suffered a recent major loss are more ... adults. , The study is published in this month,s ... . , Because compassionate behaviors are associated with better ... offer insights into ways to improve the outcomes of ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... 17, 2014) Doctors who treat patients with ... (LAM) can face an agonizing treatment decision. , ... disease and help relieve shortness of breath. But ... sirolimus can cause potentially fatal complications following transplantation. ... Daniel Dilling, medical director of Loyola University Medical ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Study recalculates costs of combination vaccines 2Health News:The ilk of human kindness 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3
... of,American Physicians and Surgeons today condemned the "vaccine ... and promised to do,everything it can to support ... "This power play obliterates informed consent and parental ... Association of American,Physicians and Surgeons (AAPS), one of ...
... status likely players in disparity, study suggests , FRIDAY, ... population, Hispanics in the United States have fewer vascular ... and often have advanced vascular disease by the time ... , While the reasons for these disparities aren,t understood, ...
... study suggests , , FRIDAY, Nov. 16 (HealthDay News) -- U.S. ... question about breast cancer: Which women have a type of ... disease? , "It,s an exciting step forward -- people have ... for about 40 years, and this is a big crack ...
... collectively spending about $18 billion per year on ... streamlining the ordering process for osteoporosis bone density ... the exam. , An estimated 10 million Americans ... System measures the mineral content in the bones ...
... ANGELES, Nov. 16 Neutrogena(R), a worldwide leader,in ... announced today that actress Diane Lane has signed ... Ms. Lane is a captivating and inspiring actress ... and daring spirit. In her new,role, she will ...
... Consumer and Disability Groups Release Updated ... Enrollment Process, WASHINGTON, Nov. 16 Members ... Medicare Rx beneficiaries, especially,those with chronic diseases and ... drug plans during open enrollment, which began,November 15. ...
Cached Medicine News:Health News:DOCTORS OPPOSE MARYLAND VACCINE ROUNDUP: Expect Dangerous Reactions When Children Are Treated Like Cattle 2Health News:DOCTORS OPPOSE MARYLAND VACCINE ROUNDUP: Expect Dangerous Reactions When Children Are Treated Like Cattle 3Health News:Hispanics Receive Fewer Surgeries for Vascular Disease 2Health News:Cell Insights May Predict Breast Cancer's Spread 2Health News:Cell Insights May Predict Breast Cancer's Spread 3Health News:Geisinger rheumatologists redesign osteoporosis, rheumatoid arthritis care 2Health News:Update: Oscar-Nominated Actress Signs on as Neutrogena(R) Brand Ambassador 2Health News:Medicare Rx Beneficiaries Urged to Review Changes to Their Drug Plans and Compare with Other Plans During Open Enrollment 2
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across ... virus, select Meijer pharmacies in Michigan ... to eligible patients, enabling Meijer pharmacists to administer tests and, ... set by a physician participating in the study. ...
(Date:1/15/2014)... , Jan. 15, 2014 Massachusetts General Hospital ... AMGN ) announced today that they have ... validate new therapeutic targets and develop novel therapies ... that affects millions worldwide. The MGH-Broad-Amgen collaboration brings ...
(Date:1/15/2014)... 2014  Manufacturers, suppliers and distributors of innovative medical-related ... their most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the ... the most litigious industry sectors of cases involving ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2
... GAITHERSBURG, Md., Aug. 23 Iomai Corporation,(Nasdaq: ... efficacy and,safety results from its double-blind Phase 2 ... has been accepted as a "late breaker",presentation at ... held in Chicago Sept. 17 to 20. ...
... Aug. 22 Novavax, Inc.,(Nasdaq: NVAX ) ... entitled,"Recombinant Baculovirus Derived HIV-1 Virus-Like Particles Elicit Potent,Neutralizing ... in,Seattle by Dr. Weimin Liu, University of Alabama ... results of pre-clinical immunological,studies of improved HIV-1 virus-like ...
Cached Medicine Technology:Iomai Announces Data from Phase 2 Field Study of Travelers' Diarrhea Vaccine Accepted for Presentation at ICAAC 2Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference 2Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference 3Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference 4Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference 5
... and comfortable eye protection Properly manufactured ... of scatter radiation. Our high quality frames ... comfort with minimized weight. Our lenses are ... that meet all industry standards. Most Pulse ...
... lenses and frames are designed with the safety ... lenses are Schott RS-520 (also called SF-6) leaded ... These lenses meet standards, as set for optical ... ,While our eyewear is protecting your eyes, ...
... Stylish and comfortable eye protection ... approximately 90% of scatter radiation. Our high ... protection and comfort with minimized weight. Our ... leaded) optics that meet all industry standards. ...
Uvex Patriot Frame...
Medicine Products: