Navigation Links
Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
Date:9/20/2007

Irvine, Calif., Sept. 20, 2007 Defects on cell-surface sugars may promote the short-term inflammation and long-term neurodegeneration that occurs in the central nervous system of multiple sclerosis patients, according to University of California, Irvine researchers.

The findings also suggest that a dietary supplement similar to glucosamine may be useful as an oral therapy to correct these defects and to treat both the short-term and the long-term symptoms of the disease. Study results appear on the online version of the Journal of Biological Chemistry.

The findings raise the possibility that these may both be treated by metabolic therapy, said Dr. Michael Demetriou, an assistant professor of neurology, and microbiology and molecular genetics. This is particularly important, as therapies are not currently available to treat neurodegeneration in MS.

In tests on mice, Demetriou found that genetic deficiencies in a process called protein glycosylation led to a spontaneous disease very similar to MS, including paralysis associated with inflammatory damage to the protective myelin coating on nerve cells and degeneration of axons and neurons. Protein glycosylation refers to the addition of specific sugars to proteins; virtually all cell-surface and secreted proteins have complex sugars attached to them.

MS is a two-stage disease, with initial attacks of inflammatory demyelination, which damages myelin, followed approximately 10 years later by a slow, progressive neurdegenerative phase marked by loss of axons and nerve cells.

The irreversible damage to the central nervous system induced by neurodegeneration in MS leads to long term disability, including paralysis, incoordination, dementia and pain, and is not targeted by currently available therapies.

Demetrious findings provide the first genetic model of MS in which both inflammatory demyelination and neurodegeneration arise from defects in a single biologi
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Increase in sugar...decrease in brain function!!!
2. Testing for blood sugar levels made easier
3. Blood Sugar Linked to Deaths in ICU
4. Sugar Cravings
5. Effective Control Of Blood Sugar Levels
6. Sugar - Sweetened Drinks Found To Increase Risk of Diabetes
7. Diabetics Can Now Be Able To Control Both Blood Sugar And Their Weight
8. Elevated Blood Sugar Levels A Risk Factor Of Heart Disease
9. Better Control Of Sugar Levels
10. Link Between High Blood Sugar And Behavioral Changes
11. Herb Found To Be Effective In Controlling Blood Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... Decora Preset 60 Minute Countdown Timer , ... ‘The Hardware City.’ The product helps in automatically switching off ... and the related electronic device is automatically turned off after ... company said, “We are glad that this amazing product is ... Countdown Timer Switch in just a few clicks. The product ...
(Date:5/24/2015)... May 24, 2015 Women's Excellence ... hair loss. Although it is unclear about the etiology ... environmental factors such as metabolism, nutritional deficiencies, thyroid abnormalities ... offer a comprehensive approach to evaluating the metabolic, nutritional ... they can help patients find a cause for their ...
(Date:5/24/2015)... NC (PRWEB) May 24, 2015 Scientists ... a paper on air quality compliance issues that may ... American workers. Surviving Mesothelioma has just posted an article ... now. , The group found airborne asbestos levels ... data collected between 1984 and 2011. , “Asbestos compliance ...
(Date:5/24/2015)... Viejo, CA (PRWEB) May 24, 2015 ProPin ... use in Final Cut Pro X. Utilize ProPin to pin ... in a given scene. , ProPin allows users to ... completely customizable in FCPX. With on-screen controls, video editors can ... allows users to pin and mark with absolute ease. , Using ...
(Date:5/24/2015)... May 24, 2015 ... CEO - The students were ... at the fourth annual A Day ... at Geneva National in Lake Geneva. ...     -Badger High School,         Jonathan Alfonso,         Bridget ...
Breaking Medicine News(10 mins):Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Women's Excellence Now Treats Menopausal Hair Loss 2Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2
... to a different festival, hot air balloon festival for ... ,This festival has been the joint efforts of Rajasthan ... 11countries are participating, who will be flying 20 balloons. ... that Rajasthan is the first in India to host ...
... a wake up call to obese baby boomers, who could be ... ,Dr. Beth Abramson, foundation spokesperson and cardiologist told CTV."It was ... have soared by nearly 60 per cent and a staggering 52 ... the group between 45 and 60, are not as fit as ...
... disorder (ADHD) is characterized by failure to have continuous ... school, conduct problems and drug abuse. // ... disease. But drug experts say that these drugs prescribed ... most serious type of warning labels. ,The ...
... that older adults with asthma are highly prone to ... researchers at the University of Adelaide said adults with ... asthma to suffer chronic conditions like heart disease, diabetes, ... Dr. Robert Adams of The Queen Elizabeth Hospital at ...
... were infected with the AIDS virus are taken to France for ... Palestinian doctor caused this tragedy, which shook the entire world. // ... to these children. ,The event occurred in Benghazi hospital, ... and condemned them to death. But now it has ordered a ...
... India's pharma major Ranbaxy Laboratories, Monday announced the launch of ... results in just a day. ,"A first of its ... that can be effectively employed for mass screening and gives ... days, which other available tests take," said SRL Ranbaxy in ...
Cached Medicine News:
(Date:5/22/2015)... Calif. , May 22, 2015 /PRNewswire/ ... the Company has commenced termination of its ... brodalumab with AstraZeneca (LON:AZN, STO:AZN and NYSE: ... inhibitor, is in development for patients with ... spondyloarthritis.  The decision was based on events ...
(Date:5/22/2015)... CHAPEL HILL, N.C. , May 22, 2015 ... is critical to pharmaceutical brand recognition and success. ... Practices, LLC conducted a study to provide pharmaceutical ... level of investment (FTEs and budget) that are ... companies. Pharmaceutical and biotech marketing managers can utilize ...
(Date:5/22/2015)... May 22, 2015 Electrophysiologist Kevin Makati, ... traveled to Boston, MA ... 2015 Heart Rhythm Society conference. These scientific sessions ... on the ideas, people and technology that propel ... a hybrid, minimally invasive cardiac operation that combines ...
Breaking Medicine Technology:Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3
... CAMBRIDGE, Mass., Oct. 25 GENFIT (Alternext: ALGFT; ISIN: ... discovery and development, focusing on the early diagnosis and ... that it has been selected by Windhover as one ... in the cardiovascular/metabolic category. This announcement is part of ...
... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... (FDA) has approved the real-time PCR COBAS® TaqMan® ... on COBAS® TaqMan® technology to support hepatitis C ... help clinicians to more confidently and effectively monitor ...
Cached Medicine Technology:GENFIT Selected by Windhover for the 2011 'Top Biopharma Projects To Watch' 2GENFIT Selected by Windhover for the 2011 'Top Biopharma Projects To Watch' 3Roche Receives FDA Approval for a Second-Generation Hepatitis C Viral Load Test 2Roche Receives FDA Approval for a Second-Generation Hepatitis C Viral Load Test 3
9" X 14" translucent plastic may be used with illuminated test cabinet or as a wall chart 20/200 to 20/15....
The PowerLab/4ST is a high-performance recording unit with built-in amplifiers and is suitable for physiology teaching. It has been designed to cover the broad experimental requirements in life scien...
... PowerLab/4SP is a high-performance data acquisition system ... applications including human and animal physiology, pharmacology, ... The unit is capable of recording from ... to 200 000 samples per second continuously ...
Worth 4-Dot Flashlight/Plastic for testing and training of visual functions and testing for fusion, suppression and/or diplopia. Red/green goggle included. Requires 2 C batteries (not included)....
Medicine Products: