Navigation Links
Cell sugar concentrations affect hyaluronan production and cancer growth
Date:2/27/2013

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth. Regulating the production of hyaluronan may be a way to prevent the spreading of cancer.

Hyaluronan is a long, linear carbohydrate polymer present in the human body. It forms a coating on the surface of many cells and plays a key role in fetal development and in the maintenance of normal tissue balance.

Under normal circumstances, hyaluronan promotes tissue healing; however, it can also maintain inflammation and promote the growth of cancer cells. Due to its high water retention capacity, hyaluronan is widely used in cosmetics and also in the medical sector, for example in the treatment of osteoarthritis symptoms and in eye surgery. Hyaluronan injected into the human body for treatment purposes is not associated with cancer risk.

Cells produce hyaluronan with the help of three cell membrane enzymes (HAS1, HAS2 and HAS3), and the production process also needs glucose derivatives.

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought. Published in Journal of Biological Chemistry, the UEF study showed that HAS1 requires a higher sugar concentration for the production of hyaluronan than HAS2 and HAS3. This finding may be significant for fighting cancer, as cancer cells are known to thrive on blood glucose. Increased glucose levels can lead to increased production of hyaluronan which, in turn, promotes cancer growth. Increased hyaluronan levels have also been found in diabetics with increased blood sugar levels. Diabetics are known to have a higher risk for breast cancer.

HAS1 also plays a significant role in inflammation, because growth factors associated with inflammation mediation, e.g., interleukins, can increase its activeness. This finding constituted part of the doctoral study of Lic. Med. Hanna Siiskonen, which was recently examined at the University of Eastern Finland.

By regulating hyaluronan levels, it may be possible to prevent the progression of cancer and other pathologies. The first clinical trials involving enzymes which break down hyaluronan have been able to slow down the growth and movement of cancer cells and to enhance the effectiveness of cancer drugs.

At the UEF Institute of Biomedicine, the research group of Professor Raija Tammi and Professor Markku Tammi has been studying hyaluronan for 25 years already, and the group's research is internationally renowned. The group focuses on cell biological mechanisms which regulate hyaluronan production. Together with its partners, the group has established a link between increased hyaluronan levels and a negative cancer prognosis in many cancer types, such as breast, prostate, colon, uterine, lung and ovarian cancer.


'/>"/>
Contact: Kirsi Rilla
kirsi.rilla@uef.fi
358-403-553-218
University of Eastern Finland
Source:Eurekalert  

Related medicine news :

1. Sugar Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld
2. FDA Should Work to Cut Sugar Levels in Sodas, Experts Say
3. Sugar Addict Claims Americans Consuming 150 lbs of Sugar Yearly
4. Stop Sugar Cravings
5. How “21 Day Sugar Detox” Helps People Overcome Sugar Addiction – Health Review Center
6. Cut Back on Sugar to Lose Some Weight
7. Metabolic protein launches sugar feast that nurtures brain tumors
8. Drinking green tea with starchy food may help lower blood sugar spikes
9. Diabetes study: Mindful eating equals traditional education in lowering weight and blood sugar
10. Sugar n Spice Not Always Nice
11. Sugar and spice and everything not so nice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell sugar concentrations affect hyaluronan production and cancer growth
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... over $100,000 for its innovative EcoQube Frame vertical micro-veggies garden on Kickstarter ... demand for the product – with nearly 2,000 consumers (and counting) already backing ...
(Date:3/24/2017)... ... March 24, 2017 , ... On ... Advanced ERISA Benefit Claims Litigation seminar in Chicago, Illinois. She will present ... majority of cases litigated under ERISA involve claims for long-term disability benefits. ...
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... partnership to prep patients for colonoscopy at the HyGIeaCare® Center that is to ... Miami, FL. , The HyGIeaCare® Prep, cleared by the U.S. Food ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... Walk with God #TruthwithGrace”: a devotional journal chronicling the writer’s path toward true ... How to Walk with God #TruthwithGrace” is the creation of published author Lea ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... inspiring stories about real people of God in congregations across the United States. ... a Presbyterian minister ordained in 1964 who has served congregations in seven states ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... Supplies - Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive ... , Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. Also, a ...
(Date:3/24/2017)... 2017  Mirabilis Medical, a Seattle ... non-invasive surgery, announced today CE Mark authorization for ... uterine fibroids throughout the European Union.  The company ... the US Food and Drug Administration to begin ... the United States.  The Mirabilis System combines high-speed ...
(Date:3/23/2017)... Mar 23, 2017 Research and Markets has ... Trends - Industry Forecast to 2025" report to their offering. ... The Global ... 6.9% over the next decade to reach approximately $3.5 billion by ... forecasts for all the given segments on global as well as ...
Breaking Medicine Technology: