A receptor that is present in the nucleus of cells can, when activated, slow the growth of tamoxifen-resistant breast cancer cells, a new study found. The study built on the recent discovery that farnesoid X receptor (FXR) a nuclear receptor found mainly in the liver is found in breast cancer tissue. Although previous research showed that FXR can slow proliferation of breast cancer cells, it was not known whether it could do the same with tamoxifen-resistant cells.
The research is part of an effort to overcome tamoxifen resistance in breast cancer patients who are good candidates for tamoxifen treatment, but who either do not respond to the drug or who develop resistance over time. These findings suggest that FXR, when activated by chenodeoxycholic acid (a bile acid) or GW4064 (a synthetic), can slow the proliferation of breast cancer cells that are tamoxifen resistant, said one of the study's authors, Cinzia Giordano.
Giordano, Donatella Vizza, Salvatore Panza, Ines Barone, Daniela Bonofiglio, Suzanne A. Fuqua, Stefania Catalano and Sebastiano And carried out the study, "Activated farnesoid X receptor inhibits growth of tamoxifen resistant breast cancer cells." The researchers are from the University of Calabria in Italy, except Dr Fuqua, who is with Baylor College of Medicine in Houston.
The study will be presented at the Experimental Biology 2010 conference on Saturday, April 24 and again on Tuesday, April 27. The American Society for Investigative Pathology is sponsoring the sessions. The conference takes place in Anaheim April 24-28.
Maintaining tamoxifen sensitivity is key
Tamoxifen is an effective breast cancer treatment for patients who are estrogen receptor positive the majority of breast cancer patients. Breast cancer cells, which need estrogen to grow, have estrogen receptors to allow them to take in estrogen. Tamoxifen interferes with the cancer cells' ability to get estrogen and in the process inhib
|Contact: Donna Krupa|
Federation of American Societies for Experimental Biology