Navigation Links
Cell signaling pathway linked to obesity, type 2 diabetes
Date:8/7/2014

WEST LAFAYETTE, Ind. - A Purdue University study shows that Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity and Type 2 diabetes, a discovery that offers new targets for treatment.

A research team led by Shihuan Kuang, associate professor of animal sciences, found that blocking Notch signaling in the fat tissue of mice caused white fat cells to transform into a "leaner" type of fat known as beige fat. The finding suggests that suppressing Notch signaling in fat cells could reduce the risk of obesity and related health problems, Kuang said.

"This finding opens up a whole new avenue to understanding how fat is controlled at the molecular level," he said. "Now that we know Notch signaling and obesity are linked in this way, we can work on developing new therapeutics."

The human body houses three kinds of fat: white, brown and beige. White fat tissue stores fatty acids and is the main culprit in weight gain. Brown fat, which helps keep hibernating animals and infants warm, burns fatty acids to produce heat. Humans lose most of their brown fat as they mature, but they retain a similar kind of fat - beige fat, which also generates heat by breaking down fatty acids.

Buried in white fat tissue, beige fat cells are unique in that they can become white fat cells depending on the body's metabolic needs. White fat cells can also transform into beige fat cells in a process known as browning, which raises the body's metabolism and cuts down on obesity.

Kuang and his team found that the Notch signaling pathway inhibits browning of white fat by regulating expression of genes that are related to beige fat tissue.

"The Notch pathway functions like a commander, telling the cell to make white fat," he said.

Suppressing key genes in the Notch pathway in the fat tissue of mice caused them to burn more energy than wild-type mic
'/>"/>

Contact: Natalie van Hoose
nvanhoos@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
2. Grb2 holds powerful molecular signaling pathway in check
3. Aurka-to-p53 signaling: A link between stem cell regulation and cancer
4. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
5. Investigational agent targets gene signaling pathways to improve response for patients with CLL
6. Signaling molecule may help stem cells focus on making bone despite age, disease
7. Astrocyte signaling sheds light on stroke research
8. Notre Dame researchers offer new insights on cancer cell signaling
9. Virginia Tech Carilion researchers find surprising relationships in brain signaling
10. MAD: Scientists shed light on braking mechanisms in cellular signaling
11. Signaling pathway may explain the body clocks link to mental illness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell signaling pathway linked to obesity, type 2 diabetes
(Date:1/22/2015)... January 22, 2015 Gabe’s Chemo Duck Program is ... the first app ever created for kids with cancer. The Chemo ... and devices, is filled with enjoyable games to help children of ... The free app helps to keep kids entertained, educated and at ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 ... after Fresenius Medical Care recalled its GranuFlo and NaturaLyte ... multidistrict litigation underway in U.S. District Court, District of ... dated January 20th, the Court has remanded a case ...
(Date:1/22/2015)... 2015 A study recently published ... journal Medicine & Science in Sports & Exercise ... help reduce gastrointestinal (GI) problems associated with physical ... in the double-blind, placebo-controlled study took 10 grams ...
(Date:1/22/2015)... January 22, 2015 Payday lending practices ... communities and cause financial distress to the states that ... at Howard University’s Center on Race and Wealth. , ... economic activity, payday loans at the same time substantially ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... and ear, nose and throat specialists at Thomas Jefferson ... sleep apnea syndrome. , In the procedure, known as ... the lower jaw which attaches to the tongue is ... back of the airway, increasing the airway space. It ...
... functions are changed by continued abuse, study finds , ... (scarring and dysfunction) of the liver have more brain ... , Researchers examined gene expression in the frontal cortex ... 14 alcoholics without cirrhosis. , "We found that the ...
... 2007 (Oakland, Calif) -- Treating diabetes during pregnancy can break ... a Kaiser Permanente study featured in the September issue of ... research shows that the risk of childhood obesity rises in ... untreated gestational diabetes nearly doubles a child,s risk of becoming ...
... says , , MONDAY, Aug. 27 (HealthDay News) -- When ... it makes the evening news, but the actual incidence of ... the victims are adults, researchers report. , After reviewing 16 ... researchers found that faculty and staff were 25 times more ...
... no state posted a decline in adult rates last year ... Americans are sliding into obesity, a clear signal that this ... fourth annual report prepared by the research group Trust for ... 31 states last year, 22 states experienced an increase for ...
... survival, functioning may have been solved in rat experiments ... rats show that human embryonic stem cells can repair ... progression of heart failure. , Using stem cells to ... so far it has been fraught with problems. ...
Cached Medicine News:Health News:Jefferson specialists studying innovative surgery for effectively treating sleep apnea 2Health News:Alcoholics With Cirrhosis Have More Brain Damage 2Health News:Treating diabetes during pregnancy can break link to childhood obesity 2Health News:Treating diabetes during pregnancy can break link to childhood obesity 3Health News:Heart Attacks at School Involve More Adults Than Kids 2Health News:Heart Attacks at School Involve More Adults Than Kids 3Health News:Obesity Rate in U.S. Still Climbing 2Health News:Obesity Rate in U.S. Still Climbing 3Health News:Obesity Rate in U.S. Still Climbing 4Health News:Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows 2Health News:Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows 3
(Date:1/22/2015)... CLEVELAND , Jan. 22, 2015  ViewRay™, a privately ... entered into an exclusive distributor agreement with ITOCHU Corporation ... radiation therapy system for the treatment of cancer in ... (me-rid-i-an) system, is the world,s first and only MRI-guided ...
(Date:1/22/2015)... THOUSAND OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... quarter and full year 2014 financial results on Tuesday, Jan. 27, ... will be followed by a conference call with the investment community ... be Robert A. Bradway , chairman and chief executive officer, ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/x3hp3g/microbiology ) has ... Microbiology Market by Product, Clinical Application & by ... to their offering. Clinical microbiology consists ... detection of infectious diseases. The respiratory diseases segment ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... Inc. (Nasdaq: GTIV ) announced today that it ... in Miami, Florida at 3:15 p.m. ET on Tuesday, March ... and Syndicated Loan Conference in Orlando, Florida at 2:05 p.m. ... will be available to the public via live audio webcasts, ...
... LITTLE FALLS, N.J., March 9, 2011 CANTEL MEDICAL ... Andrew A. Krakauer, President & CEO, will be presenting at ... Investor Forum. The formal presentation is scheduled for 10:40 AM ... New York. In addition, Mr. Krakauer will be available for ...
Cached Medicine Technology:Gentiva® Health Services to Present at Upcoming Investor Conferences 2Gentiva® Health Services to Present at Upcoming Investor Conferences 3
... refrigerator on the market today. The horseshoe ... The contoured drain channels away moisture for ... are coated with a tough, baked-on epoxy ... is reversible. The interior of the refrigerator ...
... laboratory system for pH and temperature measurements. ... when used with a temperature probe (ATC) ... easy one and two-point calibration with Auto-Find ... 1.68, 4.00, 7.00, 10.01 and 12.45) and ...
... The F340 is a basic laboratory ... compensated pH results can be obtained when ... a 3-in-1 electrode. • Fast and easy ... buffer recognition for five buffers (pH 1.68, ...
... high-end microplate reader with outstanding sensitivity and ... Fluorescence Intensity - FRET , Fluorescence Polarization ... , Luminescence , , , ... reader with fastest read times. The ultimate ...
Medicine Products: