Navigation Links
Cell signaling key to stopping growth and migration of brain cancer cells
Date:1/17/2012

Brain cancer is hard to treat: it's not only strong enough to resist most chemotherapies, but also nimble enough to migrate away from radiation or surgery to regrow elsewhere.

New research at the University of Colorado Cancer Center shows how to stop both.

Specifically, cells signal themselves to survive, grow, reproduce, and migrate. Two years ago, researchers at the CU Cancer Center showed that turning off a family of signals made brain cancer cells less robust it sensitized these previously resistant cells to chemotherapy.

But the second major problem migration potentially remained.

"I thought, aha, I have this great way to treat this cancer, but needed to check that we weren't going to cause other problems. We wondered if turning off TAM family signaling would make brain cancer cells crawl away to a new spot where they might make new problems," says Amy Keating, MD, investigator at the CU Cancer Center and senior author of the study, recently published in the journal Nature: Oncogene.

So Keating and colleagues went inside this TAM signaling family to explore how its members affect not only proliferation but migration. When they inhibited signaling through the other family member Axl, little changed (actually this was good: at least turning off this signaling pathway didn't promote cancer cell migration).

But when Keating and colleagues turned off signaling through the Mer pathway, it was neither too hot nor too cold it was just right, and these affected cancer cells were not only more sensitive to chemotherapy, but also unable to escape to safer areas of the brain.

Currently glioblastoma multiforme affects 45,000 people in the United States every year, the majority of whom will not survive 14 months after diagnosis.

"This represents a new targeted therapy, offering a potential new direction that nobody's tried before," says Keating, assistant professor of pediatrics at the University of Colorado School of Medicine.

After these extremely promising results with cell lines, Keating and colleagues are currently testing the technology in mice, after which all involved hope to move soon to human clinical trials.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Defective signaling pathway sheds light on cystic fibrosis
2. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
3. New Cancer-Fighting Strategy Focuses On Signaling Molecules
4. Different signaling pathways of cholangiocarcinoma
5. A high-fat diet alters crucial aspects of brain dopamine signaling
6. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
7. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
8. Researchers discover new signaling pathway linked to inflammatory disease
9. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
10. Researchers discover signaling pathway crucial to acute lung injury
11. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... ... in recent years. The technology is so cutting edge, in fact, the U.S. ... for stem cell procedures. However, successful patient outcomes in certain clinical stem cell ...
(Date:2/22/2017)... ... February 22, 2017 , ... Secure Exchange Solutions, ... largest network of hospitals, health information exchanges, physicians and patients, announced today that ... (ONC-HIT) 2015 Edition Health IT Module Certification via Drummond Group LLC, an Authorized ...
(Date:2/22/2017)... ... ... South Bend’s Lunkerville, the award-winning TV series that catches real people with ... a non-profit organization dedicated to helping military veterans relax, rehabilitate, and reintegrate through kayak ... Lake Denmark, New Jersey, to fish with war veteran Justin Vail from the New ...
(Date:2/22/2017)... Dallas, TX (PRWEB) , ... ... ... HCC Risk Adjustment solution leverages advanced data analytics to accurately understand each ... ensure proper reimbursement for a given population. This new solution helps transform ...
(Date:2/22/2017)... ... February 22, 2017 , ... A ... smaller and sometimes harder to reach ones, according to the results of a ... Stroke Conference in Houston by Ricardo A. Hanel, MD, PhD, neurovascular surgeon with ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... CITY, Calif. , Feb. 23, 2017 /PRNewswire/ ... pharmaceutical company focused on the development and commercialization ... acute pain, announced that it will release fourth ... on Thursday, March 2nd, 2017. AcelRx management will ... Eastern Time (1:30 p.m. Pacific Time) on March ...
(Date:2/23/2017)... 2017 ... Research and Markets has announced the addition of the ... report to their offering. The Global Antifungal Drugs ... the next decade to reach approximately $12.8 billion by 2025. ... all the given segments on global as well as regional levels presented ...
(Date:2/23/2017)... , February 23, 2017 The ... Market are GE Healthcare, Koninklijke Philips N.V., and Schiller. ... in the global market in 2015. Strong product portfolio ... factors assessed to be aiding these players remain leaders ... that the players in the global market are likely ...
Breaking Medicine Technology: