Navigation Links
Cell scaffolding protein fascin-1 is hijacked by cancer
Date:2/25/2013

A protein involved in the internal cell scaffold is associated with increased risk of metastasis and mortality in a range of common cancers finds a meta-analysis published in Biomed Central's open access journal BMC Medicine.

The protein, fascin-1, is involved in bundling together the actin filaments which form the internal scaffolding of a cell and are involved in cell movement. Though it is absent, or only present at a low level in normal epithelial cells, several small studies have shown fascin-1 to be increased in many carcinomas, but its role in metastasis and mortality risk has been uncertain.

Researchers from the University of Bristol combined and reanalysed data from 26 studies looking at five different types of carcinomas. The meta-analysis showed that increased fascin-1 was associated with increased risk of mortality in breast, colorectal and oesophageal carcinomas but not in gastric or lung carcinoma. It was also associated with disease progression in breast and colorectal carcinoma, but not lung carcinoma. It was associated with local and distant metastasis in colorectal and gastric carcinomas but there was no involvement of fascin-1 in metastasis of oesophageal carcinomas.

These results show that the picture is not simple and that different types of cancer are affected in different ways. The story of fascin-1 not only provides a biomarker and potential avenue for research into anti-cancer therapy but also demonstrates the complexity of cancer.

Josephine Adams and Richard Martin who led this study said, "Our results show that fascin-1 is associated with several types of human carcinomas. The results will help focus further research into fascin-1 as a marker and potential target for cancer therapy to the most relevant types of carcinomas."


'/>"/>

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Smart scaffolding aims to rebuild tissue from the inside
2. BioTrust Low Carb Protein Review Revealed By BioTrust Nutrition Reviews
3. Data on novel IL-1 inhibitor protein for topical treatment of dry eye disease published
4. Low-protein diet slows Alzheimers in mice
5. Protein central to cancer stem cell formation provides new potential target
6. Novel protein may help detect Lou Gehrigs disease and dementia, Mayo Clinic finds
7. Protein paves the way for correct stem cell differentiation
8. Excess protein linked to development of Parkinsons disease
9. Muscular Development Store Comments on Efficacy of Protein Blends
10. Scientists discover protein that allows safe recycling of iron from old red blood cells
11. The Muscular Development Store Comments on How Optimum Nutrition’s Protein Supplements Fit Into Your Workout
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... May 06, 2016 , ... ... of Sovaldi, which made headlines mostly for its cost despite its potential to ... moral questions surrounding the drug—part of a class called direct-acting antivirals (DAAs)—have created ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... This Mother’s ... for women everywhere. The 17th annual National Women’s Health Week takes place ... on Women’s Health are combining forces to empower women to make their health a ...
(Date:5/6/2016)... W.V. (PRWEB) , ... May 06, 2016 , ... “ ... WestBow Press) shares accounts of dying patients who have allowed those holding vigil to ... E. Kuykendall, RN, BSN, CHPN, hopes to help readers spiritually and practically gain insight ...
(Date:5/5/2016)... , ... May 05, 2016 , ... TransWipe Volume 3 ... Pro X. Drag and drop a TransWipe preset between two video clips to instantly ... corner wipes to colored panels with customizable color and orientation options. TransWipe Volume 3 ...
(Date:5/5/2016)... , ... May 05, 2016 , ... ... overall select performance in the industry’s gold standard KLAS Performance Report, ... Epic Consulting report assessed organizations that specialize in consulting services for electronic health ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 5, 2016 ... of the  "Europe Thrombocythemia Market and ... to their offering.       ... ,The latest research Europe Thrombocythemia Market ... provides comprehensive insights into Thrombocythemia pipeline ...
(Date:5/4/2016)... May 4, 2016  Compass Diversified Holdings (NYSE: ... an owner of leading middle market businesses, announced today ... March 31, 2016. First Quarter 2016 Highlights ... Reinvestment ("CAD" or "Cash Flow") of $13.6 million for ... loss of $15.0 million for the first quarter of ...
(Date:5/4/2016)... May 4, 2016 According to market ... and Demand Forecast to 2022 - Industry Insights by Slice ... Center and Others)" by P&S Market Research, the global ... 2015, and it is expected to grow at a CAGR ... slice type segment is expected to witness the faster growth, ...
Breaking Medicine Technology: