Navigation Links
Cell recycling protects tumor cells from anti-cancer therapy
Date:3/6/2008

Cells have their own recycling system: Discarded cellular components, from individual proteins through to whole cellular organs, are degraded and the building blocks re-used in a different place. The scientific term for this recycling process is autophagy. In severely damaged cells, autophagy can also be a form of programmed cell death. In this case, the cell uses the mechanism for complete self-decomposition.

Cancer cells, too, make use of autophagy especially after radiation or chemotherapy. However, why autophagy is activated in this context, is not clear. It is possible that the process contributes to the death of the treated tumor cells. But autophagy might also be an attempt by the cells to survive. Autophagy is also switched on specifically, for example, when the cell does not have enough nutrients at its disposal, explains Professor Ingrid Herr, head of the Research Group Molecular OncoSurgery of the German Cancer Research Center.

Working together with Dr. Anja Apel and scientists of the University of Tbingen, Ingrid Herr has studied the role of autophagy in cancer treatment. To this end, the investigators switched off a number of genes in tumor cells that are essential for autophagy. Subsequently, they irradiated the cells and then examined how many cells had survived the treatment. They found out that cells that had been almost completely resistant to radiation became more sensitive to radiotherapy due to blocked autophagy. No effect was found on cancer cells that had already responded well to radiotherapy before. Therefore, the researchers assume that highly aggressive cancer cells use autophagy to resist tumor therapy. The Heidelberg researchers will now investigate whether blocking the recycling system might be useful to support anti-cancer therapies.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1

Related medicine news :

1. ReCellular Named Exclusive Cell Phone Recycling Partner for Consumer Cellular
2. Ovary Removal Protects Some High-Risk Women
3. Regular Walking Protects the Aging Brain
4. Early HRT Protects a Womans Heart
5. Broccoli sprout-derived extract protects against ultraviolet radiation
6. What gives us sunburn protects crayfish against bacteria
7. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
8. Protein in embryonic stem cells control malignant tumor cells
9. New target for cancer therapy may improve treatment for solid tumors
10. Innocent bystanders can be the cause of tumor development
11. USC researchers discover novel way to develop tumor vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... 2017 , ... Based on research from Guardian’s Fourth Annual ... trying to balance both short-term and long-term benefits demands. Are employers struggling ... complexity, companies are finding that the short-term strategies used to control costs, improve ...
(Date:3/29/2017)... ... 29, 2017 , ... Altima Technologies, Inc., the maker of ... center assets and audio-video devices has recently updated its Visio Stencils library with ... and download shapes and stencils from http://www.VisioStencils.com. , New devices were ...
(Date:3/29/2017)... Linda, Ca (PRWEB) , ... March 29, 2017 , ... ... of a growing number of cancers and is touted to be the next revolution ... treatment, thus far, has been in the form of immune checkpoint inhibitors such as ...
(Date:3/29/2017)... ... , ... AvePoint , the Microsoft Cloud expert, is pleased to announce ... at the Riverfront Plaza, 901 East Byrd Street. AvePoint is celebrating with a ribbon-cutting ... and Mayor of Richmond Levar M. Stoney. , Founded in 2001, AvePoint employs more ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... first technology to directly address the resolution to globally reduce the harmful use ... patented compound of FDA and TTB approved ingredients that when infused into alcohol, ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017   Dynatronics Corporation (NASDAQ: ... Cynthia L. McHenry (Cyndi) as Vice ... leading Dynatronics manufacturing, distribution, and purchasing operations across ... CEO Kelvyn H. Cullimore, Jr. ... process conducted by the company as it continues ...
(Date:3/29/2017)... NetworkNewsWire Editorial Coverage  ... There are a number of advantages ... economic arguments also favor its legalization. The benefits include increased ... to legalize and regulate marijuana requires an ecosystem of support ... SING Profile ), American Cannabis Company (OTC: AMMJ), Kush Bottles, ...
(Date:3/29/2017)... AVIV, Israel , March 29, 2017 ... agreement in which Exeltis will obtain exclusive marketing rights for Neurim,s ... ... an age-appropriate drug targeted to treat sleep disorders in children with ... be the first sleep medication approved for children. The ...
Breaking Medicine Technology: