Navigation Links
Cell receptor could allow measles virus to target tumors

Canadian researchers have discovered that a tumor cell marker is a receptor for measles virus, suggesting the possible use of measles virus to help fight cancer. Their findings appear in the Open Access journal PLoS Pathogens on August 25th.

Viruses cause infection by attaching to specific proteins on cell surfaces called receptors. Dr. Chris Richardson of Dalhousie Medical School in Halifax, Nova Scotia, Canada and colleagues found that the tumor cell marker, PVRL4 (Nectin 4), is a receptor for measles virus.

The PVRL4 receptor is found in airway cells, and measles virus infects tissue in the respiratory tract and lungs. Large amounts of PVRL4 are also present in many cancers that originate from cells of the lung, breast, colon, and ovaries.

The receptor was discovered by comparing the proteins made in virus-susceptible cancer cells to those present in cells resistant to the virus. Because PVRL4 is found in many types of human cancers, the measles virus could potentially be used to specifically infect cancer cells and turn the immune system against tumors.

The cancer killing properties of measles virus have previously been reported by researchers at the Mayo Clinic, but this is the first time that the virus has been shown to target a common receptor that is highly expressed on the surfaces of lung, breast, colon, and ovarian cancer cells. The approach could be used to fight many different types of cancer.

Ongoing experiments are being performed to test the approach in mouse tumor models.


Contact: Christopher Richardson
Public Library of Science

Page: 1

Related medicine news :

1. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
2. Historic first images of rod photoreceptors in the living human eye
3. Older age memory loss tied to stress hormone receptor in brain
4. Entire T-cell receptor repertoire sequenced revealing extensive and unshared diversity
5. Researchers get a grip on nervous systems receptors
6. Feast or famine: Researchers identify leptin receptors sidekick as a target for appetite regulation
7. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
8. Nuclear receptors reveal possible interventions for cancer, obesity
9. New drug targets vitamin D receptors in hormone resistant prostate cancers
10. Bitter Taste Receptors Found in Lungs May Aid Asthma Patients
11. Novel biomarker may predict response to new VEGF receptor inhibitor
Post Your Comments:
(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
Breaking Medicine Technology: