Navigation Links
Cell plasticity may provide clues to origin of aggressive type of breast cancer
Date:8/4/2014

INDIANAPOLIS -- Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer.

A team of researchers, led by Candice A.M. Sauder, M.D., while a resident at the Indiana University Department of Surgery, reported online in BMC Cell Biology that healthy breast cells separated from their normal environment were able to transform into types of cells similar to those seen in metaplastic carcinoma, a form of triple negative breast cancer.

The team developed 12 cell lines from the normal, healthy breast tissue from volunteer donations to the Susan G. Komen Tissue Bank at the Indiana University Melvin and Bren Simon Cancer Center. Half of the cell lines were placed in normal culture dishes, and the other half were placed in culture dishes containing commercially available proteins that mimic the supporting structure of the breast.

The cells in the normal culture dishes remained unchanged, but the cells in the protein cultures differentiated into subtypes of cartilage, bone, muscle and nerve and into melanocytes, the pigment containing cells of the body. Some of these subtypes are also present in metaplastic carcinoma of the breast.

"The most interesting part is that we are taught in basic biology class that once a cell has reached maturation it is done changing, known in science circles as terminal differentiation," Dr. Sauder said. "This is not what we found in our experiments. We removed breast tissue and developed cell lines and, much to our surprise, discovered that mature cells were plastic and were able to change into other types of cells.

"This would argue that there are cells in the mature breast that retain the ability to have some flexibility. Terminal differentiation may not exist for all cells," Dr. Sauder said.
'/>"/>

Contact: Mary Hardin
mhardin@iu.edu
317-274-5456
Indiana University
Source:Eurekalert

Related medicine news :

1. Regulatory effects of glial cells on retinal synaptic plasticity
2. Visual system can retain considerable plasticity after extended blindness
3. New form of brain plasticity: Study shows how social isolation disrupts myelin production
4. Life Insurance for Seniors Over 70 Years Old - Lifeinsuranceover65.us Provides Online Life Insurance Quotes!
5. Life Insurance Without Medical Examinations Provides High-Risk Life Insurance
6. Company Provides New Course on Sexual Satisfaction
7. Compression Elbow Sleeve Provides Relief From Elbow Pain to Golfers and Tennis Players
8. San Diego Product Liability Firm Provides Commentary on the Latest Developments in Transvaginal Mesh Litigation
9. NJ Top Docs Proudly Presents Approved Provider, Dr. Andrew Li of Warren Skin Care Center
10. Community Health Center of Snohomish County Reveals the Differences Between Pediatricians and Family Practice Providers
11. My Clients Plus Announces Over 80 Online Therapy Notes to Help Healthcare Providers Go Paperless
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
(Date:6/24/2016)... Las Vegas, Nevada (PRWEB) , ... June 24, ... ... their Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and ... The Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer ...
(Date:6/24/2016)... ... 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... service members that have been wounded in battle and their families. Venture Construction Group ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology: