Navigation Links
Cell plasticity may provide clues to origin of aggressive type of breast cancer
Date:8/4/2014

INDIANAPOLIS -- Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer.

A team of researchers, led by Candice A.M. Sauder, M.D., while a resident at the Indiana University Department of Surgery, reported online in BMC Cell Biology that healthy breast cells separated from their normal environment were able to transform into types of cells similar to those seen in metaplastic carcinoma, a form of triple negative breast cancer.

The team developed 12 cell lines from the normal, healthy breast tissue from volunteer donations to the Susan G. Komen Tissue Bank at the Indiana University Melvin and Bren Simon Cancer Center. Half of the cell lines were placed in normal culture dishes, and the other half were placed in culture dishes containing commercially available proteins that mimic the supporting structure of the breast.

The cells in the normal culture dishes remained unchanged, but the cells in the protein cultures differentiated into subtypes of cartilage, bone, muscle and nerve and into melanocytes, the pigment containing cells of the body. Some of these subtypes are also present in metaplastic carcinoma of the breast.

"The most interesting part is that we are taught in basic biology class that once a cell has reached maturation it is done changing, known in science circles as terminal differentiation," Dr. Sauder said. "This is not what we found in our experiments. We removed breast tissue and developed cell lines and, much to our surprise, discovered that mature cells were plastic and were able to change into other types of cells.

"This would argue that there are cells in the mature breast that retain the ability to have some flexibility. Terminal differentiation may not exist for all cells," Dr. Sauder said.
'/>"/>

Contact: Mary Hardin
mhardin@iu.edu
317-274-5456
Indiana University
Source:Eurekalert

Related medicine news :

1. Regulatory effects of glial cells on retinal synaptic plasticity
2. Visual system can retain considerable plasticity after extended blindness
3. New form of brain plasticity: Study shows how social isolation disrupts myelin production
4. Life Insurance for Seniors Over 70 Years Old - Lifeinsuranceover65.us Provides Online Life Insurance Quotes!
5. Life Insurance Without Medical Examinations Provides High-Risk Life Insurance
6. Company Provides New Course on Sexual Satisfaction
7. Compression Elbow Sleeve Provides Relief From Elbow Pain to Golfers and Tennis Players
8. San Diego Product Liability Firm Provides Commentary on the Latest Developments in Transvaginal Mesh Litigation
9. NJ Top Docs Proudly Presents Approved Provider, Dr. Andrew Li of Warren Skin Care Center
10. Community Health Center of Snohomish County Reveals the Differences Between Pediatricians and Family Practice Providers
11. My Clients Plus Announces Over 80 Online Therapy Notes to Help Healthcare Providers Go Paperless
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... or dementia. However, many long-term care insurance companies have a waiver for care if ... the 90-day elimination period, when the family pays for care, is often waived, so ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... Sept. 25, 2017   Montrium , an ... solutions, today—from the IQPC Trial Master Files & ... NL)—announced that EastHORN Clinical Services has selected ... and TMF management. EastHORN, a leading European contract ... to increase transparency to enable greater collaboration with ...
(Date:9/19/2017)... medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound energy ... ... Jim Bertolina, PhD ... Tom Tefft ... executive Josh Stopek , PhD, who has led R&D and business development teams at ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
Breaking Medicine Technology: