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Cell phones using lens-free imaging promise to improve health monitoring
Date:12/22/2008

Cell phones have already revolutionized the way people around the world communicate and do business. Thanks to advances being made at UCLA, they are about to do the same thing for medicine.

In the lab of UCLA electrical engineering professor Aydogan Ozcan, a prototype cell phone has been constructed that is capable of monitoring the condition of HIV and malaria patients, as well as testing water quality in undeveloped areas or disaster sites. The innovative imaging technology was invented by Ozcan, a member of the California NanoSystems Institute at UCLA, and has been miniaturized by researchers in his lab to the point that it can fit in standard cell phones.

The imaging platform, known as LUCAS (Lensless Ultra-wide-field Cell monitoring Array platform based on Shadow imaging), has now been successfully installed in both a cell phone and a webcam. Both devices acquire an image in the same way, using a short wavelength blue light to illuminate a blood, saliva or other fluid sample. LUCAS captures an image of the microparticles in the solution using a sensor array.

Because red blood cells and other microparticles have a distinct diffraction pattern, or shadow image, they can be identified and counted virtually instantaneously by LUCAS using a custom-developed "decision algorithm" that compares the captured shadow images to a library of training images. Data collected by LUCAS can then be sent to a hospital for analysis and diagnosis using the cell phone, or transferred via USB to a computer for transmission to a hospital.

LUCAS is not a substitute for a microscope but rather a complement. While microscopes can produce detailed images, images produced by LUCAS are grainy and pixelated. The LUCAS platform's advantage lies in its ability to nearly instantaneously identify and count microparticles, something that is time consuming and difficult to do with a microscope in resource-limited settings. Also, because LUCAS
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Contact: Mike Rodewald
mrodewald@cnsi.ucla.edu
310-267-5883
University of California - Los Angeles
Source:Eurekalert

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