Navigation Links
Cell pathway on overdrive prevents cancer response to dietary restriction
Date:3/11/2009

ne in which the PTEN gene could be switched on or off, Kalaany tested whether a change in the PTEN gene alone could affect a tumor's sensitivity to DR. When the PTEN gene was turned off, the cancer cells were not affected by dietary restriction, and tumor size increased similarly in control and DR mice. But when PTEN was turned on, thereby restoring normal function to the PI3K pathway, the cells became sensitized to dietary restriction and tumor size was smaller in the DR group.

This research was confirmed in two mouse models of cancer, one with prostate cancer caused by PTEN deletion and one with lung cancer and a functioning PTEN gene. Again, the mice without the PTEN gene did not respond to dietary restriction, but the mice with a functioning PTEN gene were sensitive to dietary restriction.

Sabatini says that Kalaany's results could lead to cancer treatments tailored to the characteristics of an individual patient's tumor cells.

"Her findings suggest that if we have therapies that mimic dietary restriction, we could better predict which tumors would respond to those dietary restriction-mimicking drugs and which ones would not," says Sabatini.

Sabatini is also intrigued by the inverse relationship between too much food and an increase in tumors. "We already know that the United States has an epidemic of obesity and that obesity is probably the biggest contributor to cancer in the U.S., even more so than smoking. Does this research have anything to do with that correlation between obesity and cancer, that if we make animals really obese, that this pathway is also involved in determining their sensitivity to cancer? Answering that question is the next step."


'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay
3. Pathway to cell death redefined in landmark study
4. Pathway to cell death redefined in landmark study
5. Second pathway behind HIV-associated immune system dysfunction identified
6. Cell pathway, disease linked to histone action
7. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
8. Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
9. Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
10. UC Davis researchers discover novel pathway to increased inflammation in diabetes patients
11. UC Davis researchers identify a cellular pathway that makes prostate cancer fatal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... The Rottenstein Law Group LLP, a New York-based nationwide ... Information Center at http://www.rotlaw.com/tylenol , dedicated to issues ... considering filing lawsuits. , The painkiller Tylenol (acetaminophen) ... according to a 2009 report from the U.S. Food ... FDA warned consumers against using more than the recommended ...
(Date:5/23/2013)... May 23, 2013 Dr. Katherine Ahn ... charitable organization in Orange County, OCCares , will hold ... County. The event details are as follows: , Sunday ... Auditorium, 13732 Clinton Street, Garden Grove, CA 92843 , The ... music by Christian vocalists Charmaine & Jonathan Thulin. There ...
(Date:5/23/2013)... The vast majority of Americans believe it’s possible ... level of physical activity, the healthfulness of their diet ... that control. Those are among the findings of ... & Health Survey. , According to the Survey, 90 ... great deal of control” or “complete control” over their ...
(Date:5/23/2013)... 23, 2013 Click here to read ... start-ups are increasingly seeing their success develop through ... companies, according to new research carried out by ... The company has compiled its research into a series ... of the research have shown the general trend that ...
(Date:5/23/2013)... IL (PRWEB) May 23, 2013 Jeanne ... fifth anniversary of its popular and only free OCD ... a successful continuing resource for OCD sufferers, the group ... OCD, and related disorders. This allows group participants ... and Exposure and Response Prevention. , “Participants in Beyond ...
Breaking Medicine News(10 mins):Health News:Rottenstein Law Group LLP Now Accepting Tylenol Cases, Announces New Tylenol Lawsuit Information Center 2Health News:Dr. Katherine Ahn is Proud to Announce the Launch Her Family's New Charity OCCares 2Health News:Dr. Katherine Ahn is Proud to Announce the Launch Her Family's New Charity OCCares 3Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 2Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 3Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 4Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 2Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 3Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 4Health News:Beyond OCD Support Group Marks Fifth Anniversary 2
... 6 Medical professionals,have long sought new treatments for ... A new therapy, based on,hypnosis, is currently being tested ... of surgery., Your Cancer Today interviews Guy H. ... Montgomery,s study looked at two groups of patients,facing surgery ...
... women surveyed about their beliefs surrounding miscarriage and birth defects ... negatively affect her baby. , One in four of ... could hurt her unborn child, and one in five believed ... Despite those beliefs, relatively few of the women surveyed blamed ...
... WHITE PLAINS, N.Y., DECEMBER 5, 2007 The preterm birth ... show a continued increase, underscoring the urgent need for a ... The more we learn about the terrible consequences of an ... to understand what causes preterm birth and how it can ...
... 6, 2007 -- A new study recently published in the ... novel benefit in slenderizing thighs. , The Brazilian researchers studied ... 7 percent caffeine solution. The women used the cream twice ... their subjects measurements at the end of the study, the ...
... Taking ,Unacceptable Risk, With Patient, FORT WORTH, Texas, ... million to the family of a 75-year-old Fort Worth ... his symptoms., Jurors deliberated about six hours over ... 236th District Court of Judge Thomas W. Lowe III.,The ...
... $24 Million Worth of,Prescription Drugs Through Rogue Internet ... Lifestyle, Including Seven,Convertibles, Four Stretch Limousines & Maybach ... National Health,Care Anti-Fraud Association (NHCAA) today is presenting ... and Treasury the 2007,Fraud "Investigation of the Year" ...
Cached Medicine News:Health News:Reducing Pain via Hypnosis, This Week on Your Cancer Today (TM) 2Health News:Miscarriage myths persist despite prevalence of medical information 2Health News:Miscarriage myths persist despite prevalence of medical information 3Health News:Miscarriage myths persist despite prevalence of medical information 4Health News:Jury Awards $5.25 Million Malpractice Verdict Against Fort Worth Doctor 2Health News:NHCAA Presents 2007 Fraud 'Investigation of the Year' Award to U.S. Departments of Justice, HHS, and Treasury for Convicting Internet Pharmacy 'Drug Kingpin' 2Health News:NHCAA Presents 2007 Fraud 'Investigation of the Year' Award to U.S. Departments of Justice, HHS, and Treasury for Convicting Internet Pharmacy 'Drug Kingpin' 3
(Date:5/23/2013)... -- Israel Brain Technologies (IBT) has announced the ... 1 st International Brain Technology Conference, which ... in Tel Aviv , recently ranked as ... by the Wall Street Journal and the epicenter ... showcase the latest breakthroughs in neuroscience and brain technology and ...
(Date:5/23/2013)... 23, 2013 EarlySense, the market ... the prize for ,Best Novel Idea, at the 8 ... Teams International Conference, hosted this year in the UK ... a clinical research team studying the impact of the ... Los Angeles . The prize was ...
(Date:5/23/2013)... , May 23, 2013 SynCardia Systems, Inc. ... only FDA, Health Canada and CE ( Europe ... the Glasgow Science Centre in Scotland ... featuring the SynCardia temporary Total Artificial Heart ... its $3 million Bodyworks Exhibition, one of the most ...
Breaking Medicine Technology:Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 2Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 3Clinical Team Researching the Impact of the EarlySense System Wins 'Best Novel Idea' Prize at the Rapid Response Systems and Medical Emergency Teams 2013 8th International Conference 2Clinical Team Researching the Impact of the EarlySense System Wins 'Best Novel Idea' Prize at the Rapid Response Systems and Medical Emergency Teams 2013 8th International Conference 3Clinical Team Researching the Impact of the EarlySense System Wins 'Best Novel Idea' Prize at the Rapid Response Systems and Medical Emergency Teams 2013 8th International Conference 4Glasgow Science Centre Features SynCardia Total Artificial Heart in $3 Million Exhibition 2Glasgow Science Centre Features SynCardia Total Artificial Heart in $3 Million Exhibition 3
... States Food and Drug Administration ("FDA") said its primary results ... risk of blood clots for women who use drospirenone-containing birth ... safety of Yaz and Yasmin is the subject of approximately ... Pleas Judge Sandra Mazer Moss, Coordinating Judge of the Complex ...
... BEACH, Calif., Sept. 27, 2011 For the third ... InformationWeek 500 annual listing of the nation,s most innovative ... honored for development and implementation of its Treatment ... communities real-time cost estimates specific to their coverage plan, ...
Cached Medicine Technology:FDA Issues Safety Communication Regarding Increased Risk of Blood Clots with Certain Birth Control Pills 2Medical Mutual of Ohio Earns a Spot on 2011 InformationWeek 500 List of Top Technology Innovators Across America 2Medical Mutual of Ohio Earns a Spot on 2011 InformationWeek 500 List of Top Technology Innovators Across America 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: