Navigation Links
Cell pathway on overdrive prevents cancer response to dietary restriction
Date:3/11/2009

r size and incidence. However, some cancers' growth rate was unaffected by a decrease in food consumption. The reason for this difference remained unclear.

To determine how various tumor types are affected by dietary resistance, Kalaany injected cells from human prostate, breast, brain, and colon cancers into mice in an experimental protocol used frequently to study human cancers. The mice then ate as much as they liked (control group) or received 60% of the caloric intake of their counterparts (the dietary restriction (DR) group). Both groups ingested the same amounts of vitamins and minerals. After a few weeks, Kalaany saw that the cancers could be divided into DR-sensitive tumors, with significantly lower tumor volumes in the DR mice than in control mice, or DR-resistant tumors, whose sizes were apparently unaffected by normal or restricted diets.

Kalaany then grew the same cancer cells in Petri dishes to see how the DR-sensitive and DR-resistant cancers respond to food-related hormones in the body. The cancers were grown solutions containing increasing amounts of insulin, insulin-like growth factor 1 (IGF1) or in a solution without these hormones. The results supported the previous experiment: those cancer cells that were DR-sensitive in the mice were also stunted by a lack of insulin and IGF1; those cancer cells that were DR-resistant in the mice were unaffected by changes in insulin and IGF1 levels.

Because the difference between the two groups was sensitivity or insensitivity to insulin and IGF1, Kalaany thought the insensitive tumors may have something amiss in a cellular process called the PI3K pathway, which is activated by insulin/IGF1. A search for mutations in two genes found in the PI3K pathway that are often associated with cancer (PI3KCA and PTEN), revealed that DR-resistant cells had mutations in one or the other of the genes, while DR-sensitive cells showed no such mutations.

Using a DR-resistant tumor cell li
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay
3. Pathway to cell death redefined in landmark study
4. Pathway to cell death redefined in landmark study
5. Second pathway behind HIV-associated immune system dysfunction identified
6. Cell pathway, disease linked to histone action
7. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
8. Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
9. Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
10. UC Davis researchers discover novel pathway to increased inflammation in diabetes patients
11. UC Davis researchers identify a cellular pathway that makes prostate cancer fatal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Atlanta, Georgia (PRWEB) September 18, 2014 ... announced the winners of its 2nd TAG Social Savvy ... the Junior Achievement’s Chick-fil-A Foundation Discovery Center in Downtown ... social media. , Turner Sports was honored with ... This year’s event also recognized innovators in 6 ...
(Date:9/18/2014)... A sold-out crowd of more than ... supported United Way of Westchester and Putnam ... event Monday, Sept. 15. Proceeds from the event will ... and Putnam, such as providing healthy foods to low-income ... risky behaviors like drug and alcohol usage. , Two ...
(Date:9/18/2014)... News) -- Teens and young adults who,ve been mentored ... provides them with greater responsibility and independence early on ... "We found that having a mentor provides a clear ... author, Steve McDonald, an associate professor of sociology at ... release. In conducting the study, published online ...
(Date:9/18/2014)... show promise in slowing the progression of mesothelioma, ... to asbestos. Scientists from Case Western Reserve University ... application of curcumin, a derivative of the spice ... protein inhibitor known to combat the progression of ... 14 online edition Clinical Cancer Research ; ...
(Date:9/18/2014)... Research led by Paulo Rodriguez, PhD, an assistant ... Health New Orleans, Stanley S. Scott Cancer Center, has ... Chop plays in the body,s ability to fight cancer. ... the activity and accumulation of cells that suppress the ... Orleans research team showed that when they removed Chop, ...
Breaking Medicine News(10 mins):Health News:Winners Honored at 2014 TAG Social Savvy Awards 2Health News:Winners Honored at 2014 TAG Social Savvy Awards 3Health News:United Way Celebrates “Best Chefs and Fine Wines” at Sold-Out Culinary Event 2Health News:United Way Celebrates “Best Chefs and Fine Wines” at Sold-Out Culinary Event 3Health News: Mentors May Steer Young People Toward More Rewarding Careers 2Health News:Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize STAT3 in mesothelioma 2Health News:Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize STAT3 in mesothelioma 3Health News:LSU Health research discovers means to free immune system to destroy cancer 2
... of heart disease. But almost everyone feels that exercising is ... that skinny people are also prone to developing heart diseases ... genesis of various heart ailments. ,Dr. Peter T. Katzmarzyk ... study, says that heart disease does not develop from a ...
... is playing havoc with the economies of,developed countries like ... of vaccinating the animals for the past three decades. ... regular basis is the best,means of preventing the spread ... joint,director of the Bangalore-based Indian Veterinary Research Institute (under,ICAR), ...
... government says that smoking will turn out to be the ... of even HIV. The British broadcasting corporation reported on Monday ... than any other disease in the next 20 years. The ... United Kingdom, says smoking and other tobacco related deaths would ...
... has zeroed in on the culprit behind the falling age ... said to be the cause for girls attaining puberty as ... explanation for this is growing childhood obesity, intake of rich ... the role of estrogen, a female hormone, in attaining puberty.,They ...
... Most people are paranoid about heart disease. One survey said ... hepatitis and heart disease. Whenever people get to read something ... they start worrying at times over trivial problems based on ... recent study conducted in Austria says that chronic infections can ...
... an associate professor of computer science at the Washington ... the way children understand and speak languages at such ... meeting of the American association for the advancement of ... to pick up language and to become familiar with ...
Cached Medicine News:Health News:India takes on foot-and-mouth disease by vaccinating animals 2
(Date:9/18/2014)... BCC Research report discusses the medical device technologies in terms ... and opportunities for different devices and regions. It includes forecasts ... the report focuses on technological trends in recent years in ... and Japan . Use ... device technologies market. - Analyze market structure, including segments and ...
(Date:9/18/2014)... , Sept. 18, 2014   Fruit Street Health ... an initial seed round of funding. ... led by a series of individual investors, the majority ... participated in the initial round are; Houston Cardiology ... Center Urologist Stacy Childs, Rapha Family Medicine Practice Owner ...
(Date:9/18/2014)...  ADM Tronics Unlimited, Inc. (OTCQB: ADMT) has ... corporate Advisory Board for business development. ... Medical School and Visiting Professor at the University ... degree in Electronics Engineering and his Ph.D. in ... After spending a year as a visiting researcher ...
Breaking Medicine Technology:Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 2ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 3
... KONG, Dec. 21, 2011 /PRNewswire-Asia-FirstCall/ -- Golden Meditech ... 801.HK; 910801.TW), China,s leading integrated healthcare enterprise, today announced ... shares in December 2011, equivalent to 0.49% of the ... of HK$0.84 per share.Mr. KAM Yuen, Chairman and Chief ...
...  BioDelivery Sciences International, Inc. (Nasdaq: ... study, BNX-102, assessing the pharmacokinetics of its ...  The results confirm the final formulation and ... the pivotal comparative pharmacokinetic study versus Suboxone.  ...
Cached Medicine Technology:Golden Meditech Repurchases Shares 2BioDelivery Sciences Announces Confirmation of Final Formulation of BEMA Buprenorphine/Naloxone Based on Positive BNX-102 Study 2BioDelivery Sciences Announces Confirmation of Final Formulation of BEMA Buprenorphine/Naloxone Based on Positive BNX-102 Study 3BioDelivery Sciences Announces Confirmation of Final Formulation of BEMA Buprenorphine/Naloxone Based on Positive BNX-102 Study 4
For the qualitative detection of human Chorionic Gonadotrophin (HCG) in urine or urine and serum specimens...
ZyDoc offers a full medical transcription and documentation solution....
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: