Navigation Links
Cell pathway, disease linked to histone action
Date:10/26/2007

BIRMINGHAM, Ala. University of Alabama at Birmingham (UAB) researchers have discovered a key cell-signaling pathway that regulates cell progression and switches on front-to-back body patterning in tadpoles.

Uncovering this signaling pathway will greatly assist scientists in understanding the complex DNA and cell interplay that leads to abnormal cell growth, a hallmark of cancer and other diseases.

The UAB team focused on the pathway that led to deregulation of a protein called H2A and how those changes influenced cell growth. The results are published in the journal Nature.

H2A is a part of a class of proteins called histones, which hold their own code for how the genetic DNA inside cells is used to form tissues, bones and other structures. In the Nature study, a protein was identified that modifies H2A, which in turn regulates normal cell pathways and cell growth.

When the function of this protein was blocked in tadpole embryos, the front-to-back body patterning that happens as they mature was altered, said Hengbin Wang, Ph.D., an assistant professor in the UAB Department of Biochemistry and Molecular Genetics and lead author on the study.

Wang said the findings show potential in future research to identify biochemical agents or drugs that can target histones and influence cell production.

Earlier research has looked at whether targeting histones during certain times of biological development will effectively switch on or off certain pathways or patterning signals. Putting our finger on this switch would give geneticists, doctors and biochemists unprecedented control in stopping tumor growth and other human diseases, Wang said.

This finding goes along way toward helping us understand how histones like H2A are modified in the cell cycle and what that means for normal or abnormal physiological growth, he said.

One thing we know for sure is that modifying histones is very important to chromatin structure and function, he said. Chromatin is the DNA and protein mixture that makes up chromosomes, the threadlike structures inside cells that are necessary for reproduction.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
2. Transdermal HRT not cardioprotective in postmenopausal women with Coronary Artery Disease
3. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
4. Vitamins-The answer to Heart Disease?
5. Fight Heart disease and Pain with Meditation
6. Heart disease in the newborn is related to maternal malnutrition
7. Starvation in pregnant women can cause heart disease to their children
8. Individuals with sleep related breathing disorders more prone to heart disease
9. And now they say infections can cause heart disease!!!!
10. And now they say infections can cause heart disease!!!!
11. India takes on foot-and-mouth disease by vaccinating animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , ... March 23, 2017 , ... It’s that time ... many students are thinking about summer internships , which can be frustrating when ... The pros at Garden Media Group, a boutique public relations firm outside of Philadelphia, ...
(Date:3/23/2017)... Chatham, New Jersey (PRWEB) , ... March 23, ... ... a developer of herbal-based and non-steroidal skincare products, was awarded as winners of ... with innovation products. This competition was hosted jointly by HSN and Good Housekeeping. ...
(Date:3/23/2017)... ... ... News Advisory/Interview Opportunity , After six years of advocacy, testimony and grassroots organizing, ... health and the environment and is calling on the United States to follow the ... of European citizens, the European Union (EU) will, beginning next year, ban the use ...
(Date:3/23/2017)... ... ... “A Respectful Response To Atheist Manifesto”: theological refutation of ... the creation of published author Richard Hostetter, a former missionary in Africa who ... degrees from Kent State University and the University of Ghana. , Published by ...
(Date:3/22/2017)... CA (PRWEB) , ... March 22, 2017 , ... ... community, announces the publication of the first issue of its companion print magazine. ... the public about cosmetic surgery thanks to information provided by board-certified doctors from ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... Ampio Pharmaceuticals, Inc. (NYSE MKT: AMPE), ... low molecular weight fraction of human serum albumin ... re-issuing its previous release that was made on March ... required under the NYSE MKT Company Guide Sections ... along with the previously disclosed update of corporate ...
(Date:3/22/2017)...  ImaginAb Inc. today announced the appointment of Martyn Coombs ... , chairman of ImaginAb, said "At ImaginAb we have exciting science ... relevant to our business, particularly in commercializing and making step changes ... we can realize our potential." ... Mr. Coombs is a recognized industry leader in nuclear ...
(Date:3/22/2017)... , 22. März 2017   ... und weltweit tätige Anbieter von Produkten und ... den Erwerb von EPL Archives Inc. bekannt, ... der Kunden im kompletten Zyklus regulierter Forschung, ... von Proben, Speicherung von Dokumenten und Zusatzdienstleistungen ...
Breaking Medicine Technology: