Navigation Links
Cell pathway, disease linked to histone action
Date:10/26/2007

BIRMINGHAM, Ala. University of Alabama at Birmingham (UAB) researchers have discovered a key cell-signaling pathway that regulates cell progression and switches on front-to-back body patterning in tadpoles.

Uncovering this signaling pathway will greatly assist scientists in understanding the complex DNA and cell interplay that leads to abnormal cell growth, a hallmark of cancer and other diseases.

The UAB team focused on the pathway that led to deregulation of a protein called H2A and how those changes influenced cell growth. The results are published in the journal Nature.

H2A is a part of a class of proteins called histones, which hold their own code for how the genetic DNA inside cells is used to form tissues, bones and other structures. In the Nature study, a protein was identified that modifies H2A, which in turn regulates normal cell pathways and cell growth.

When the function of this protein was blocked in tadpole embryos, the front-to-back body patterning that happens as they mature was altered, said Hengbin Wang, Ph.D., an assistant professor in the UAB Department of Biochemistry and Molecular Genetics and lead author on the study.

Wang said the findings show potential in future research to identify biochemical agents or drugs that can target histones and influence cell production.

Earlier research has looked at whether targeting histones during certain times of biological development will effectively switch on or off certain pathways or patterning signals. Putting our finger on this switch would give geneticists, doctors and biochemists unprecedented control in stopping tumor growth and other human diseases, Wang said.

This finding goes along way toward helping us understand how histones like H2A are modified in the cell cycle and what that means for normal or abnormal physiological growth, he said.

One thing we know for sure is that modifying histones is very important to chromatin structure and function, he said. Chromatin is the DNA and protein mixture that makes up chromosomes, the threadlike structures inside cells that are necessary for reproduction.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
2. Transdermal HRT not cardioprotective in postmenopausal women with Coronary Artery Disease
3. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
4. Vitamins-The answer to Heart Disease?
5. Fight Heart disease and Pain with Meditation
6. Heart disease in the newborn is related to maternal malnutrition
7. Starvation in pregnant women can cause heart disease to their children
8. Individuals with sleep related breathing disorders more prone to heart disease
9. And now they say infections can cause heart disease!!!!
10. And now they say infections can cause heart disease!!!!
11. India takes on foot-and-mouth disease by vaccinating animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... a master charity program created to assist the local community. Pledging to select ... leaders and nonprofit organizations in the area. Their goal is to bring community ...
(Date:2/10/2016)... FRANCISCO, Calif. (PRWEB) , ... February 10, 2016 , ... ... Best Water Brand. There were three leading bottled water brand owners that topped the ... services that enhance connectivity and optimize conversion. The premier brand was Tibet 5100, a ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... Dr. Jessica ... the practice is now accepting new dental patients and families in the North Metro ... dental care services from cleanings to cosmetic dentistry, and all in the most relaxing ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... bring together more than 200 of the country’s top healthcare executives to share ... “The true benefit of the Forum is the provider-centric perspective, experience, expertise and ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- Fotona, based in the U.S. and Europe ... Lightwalker dental laser at the upcoming 151 st Midwinter ... in booth #4815. The ST PRO is a full featured ... features of the award winning, industry leading Lightwalker ATS. At an ... be very attractive to many dentists hesitating to incorporate lasers ...
(Date:2/10/2016)... Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ), today ... and full year ended December 31, 2015. ... transformational year for Vanda with the continued growth of ... of HETLIOZ for Non-24," said Mihael H. Polymeropoulos, M.D., ... our U.S. product portfolio builds on this success and ...
(Date:2/10/2016)... 2016 A new report from business intelligence provider GBI ... the Alzheimer,s disease market will more than double from just under $5 billion ... Growth Rate (CAGR) of 11%. Canada , ... Spain , the UK, and Japan , ... --> Canada , France , ...
Breaking Medicine Technology: