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Cell microenvironments hold key to future stem cell therapies
Date:2/27/2009

said. "By impairing a signaling pathway known as Notch, we are able to revert malignant breast cancer cells to a normal phenotype."

In previous studies, Bissell and her group had identified signaling pathways that could cause "phenotypic reversion" of breast cancer cells but this had never been tried before with stem cells.

Said Bissell, "The MEArray approach may be able to teach us how to direct stem cell function in a therapeutic setting and possibly to re-program non-stem cells to acquire other stem cell fates."

While the MEArrays in this study were used to study adult stem and progenitor cells in breast tissue, the technique should also be applicable to any of the other 200 different types of tissue cells within other organs, LaBarge said.


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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

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Cell microenvironments hold key to future stem cell therapies
Cell microenvironments hold key to future stem cell therapies
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